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    anln anillin, actin binding protein [ Danio rerio (zebrafish) ]

    Gene ID: 562517, updated on 12-Sep-2024

    Summary

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    Official Symbol
    anlnprovided by ZNC
    Official Full Name
    anillin, actin binding proteinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-4486
    See related
    Ensembl:ENSDARG00000060917 AllianceGenome:ZFIN:ZDB-GENE-030131-4486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb74d05; wu:fd10d09; wu:fi41f04; si:ch211-197n10.2
    Summary
    Acts upstream of or within asymmetric cell division; glomerular filtration; and glomerulus development. Predicted to be active in actomyosin contractile ring. Is expressed in brain; eye; optic cup; optic tectum; and retina. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See anln in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (35433155..35450667, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (35846035..35863596, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 19B Neighboring gene adenylate kinase 2 Neighboring gene protein tyrosine phosphatase 4A2b Neighboring gene collagen, type VIII, alpha 2 Neighboring gene uncharacterized LOC101883771

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. Hall G, et al. J Am Soc Nephrol, 2018 Aug. PMID 30002222, Free PMC Article
    2. The Zebrafish Anillin-eGFP Reporter Marks Late Dividing Retinal Precursors and Stem Cells Entering Neuronal Lineages. Cepero Malo M, et al. PLoS One, 2017. PMID 28107513, Free PMC Article
    3. Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation. Mooney MR, et al. Front Genet, 2019. PMID 31681410, Free PMC Article
    4. Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function. Paolini A, et al. Development, 2015 Mar 1. PMID 25655700
    5. Mutations in the gene that encodes the F-actin binding protein anillin cause FSGS. Gbadegesin RA, et al. J Am Soc Nephrol, 2014 Sep. PMID 24676636, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The study provides the in vivo evidence for the requirement of Anillin during asymmetric neurogenic divisions.
      Title: Asymmetric inheritance of the apical domain and self-renewal of retinal ganglion cell progenitors depend on Anillin function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC158365

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in actomyosin contractile ring assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within asymmetric cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerular basement membrane development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in septin ring organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    anillin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102676.2 → NP_001096146.2  anillin

      Status: VALIDATED

      Source sequence(s)
      BX957241
      UniProtKB/TrEMBL
      A0A8M1NE25, F1QJH8
      Related
      ENSDARP00000102493.2, ENSDART00000113574.4
      Conserved Domains (4) summary
      cd01263
      Location:1016 → 1142
      PH_anillin; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:1019 → 1138
      PH; PH domain
      pfam08174
      Location:835 → 985
      Anillin; Cell division protein anillin
      pfam16018
      Location:170 → 254
      Anillin_N; Anillin N-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      35433155..35450667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159661.4 → XP_005159718.1  anillin isoform X1

      UniProtKB/TrEMBL
      A0A286Y917, A0A8M2B6G3
      Related
      ENSDARP00000143654.1, ENSDART00000179357.2
      Conserved Domains (4) summary
      cd01263
      Location:1034 → 1160
      PH_anillin; Anillin Pleckstrin homology (PH) domain
      pfam00169
      Location:1037 → 1156
      PH; PH domain
      pfam08174
      Location:835 → 985
      Anillin; Cell division protein anillin
      pfam16018
      Location:170 → 254
      Anillin_N; Anillin N-terminus

    2. XM_068215161.1 → XP_068071262.1  anillin isoform X2

    RNA

    1. XR_011007452.1 RNA Sequence

    2. XR_011007453.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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