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    Ccdc198 coiled-coil domain containing 198 [ Mus musculus (house mouse) ]

    Gene ID: 67082, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc198provided by MGI
    Official Full Name
    coiled-coil domain containing 198provided by MGI
    Primary source
    MGI:MGI:1914332
    See related
    Ensembl:ENSMUSG00000021850 AllianceGenome:MGI:1914332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700011H14Rik
    Summary
    Involved in energy homeostasis. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including gut; metanephros; neural tube; testis; and yolk sac. Orthologous to human CCDC198 (coiled-coil domain containing 198). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 9.1), testis adult (RPKM 7.4) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc198 in Genome Data Viewer
    Location:
    14 C1; 14 25.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (49463815..49482902, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (49226358..49245445, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1570 Neighboring gene STARR-seq mESC enhancer starr_36626 Neighboring gene ribosomal protein L19, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_36627 Neighboring gene N(alpha)-acetyltransferase 30, NatC catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_36630 Neighboring gene solute carrier family 35, member F4 Neighboring gene STARR-seq mESC enhancer starr_36631 Neighboring gene predicted gene, 52146 Neighboring gene STARR-seq mESC enhancer starr_36633 Neighboring gene predicted gene, 22116

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology. Petersen J, et al. Nat Commun, 2023 May 29. PMID 37248239, Free PMC Article
    2. A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE). Hou J, et al. BMC Dev Biol, 2007 Aug 2. PMID 17683524, Free PMC Article
    3. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686
    4. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in energy homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    factor associated with metabolism and energy
    Names
    uncharacterized protein C14orf105 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025956.4 → NP_080232.3  factor associated with metabolism and energy

      See identical proteins and their annotated locations for NP_080232.3

      Status: VALIDATED

      Source sequence(s)
      AK005866, AK007176
      Consensus CDS
      CCDS26996.1
      UniProtKB/Swiss-Prot
      A9C481, Q8R0Q0, Q9CPZ1
      UniProtKB/TrEMBL
      A0A2K6EDK1
      Related
      ENSMUSP00000154726.2, ENSMUST00000228936.2
      Conserved Domains (1) summary
      pfam15398
      Location:1 → 292
      DUF4619; Domain of unknown function (DUF4619)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      49463815..49482902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519439.4 → XP_006519502.1  factor associated with metabolism and energy isoform X2

      UniProtKB/TrEMBL
      A0A2K6EDK1
      Related
      ENSMUSP00000022398.9, ENSMUST00000022398.15
      Conserved Domains (1) summary
      pfam15398
      Location:1 → 291
      DUF4619; Domain of unknown function (DUF4619)

    2. XM_011245156.4 → XP_011243458.1  factor associated with metabolism and energy isoform X1

      See identical proteins and their annotated locations for XP_011243458.1

      UniProtKB/Swiss-Prot
      A9C481, Q8R0Q0, Q9CPZ1
      UniProtKB/TrEMBL
      A0A2K6EDK1
      Conserved Domains (1) summary
      pfam15398
      Location:1 → 292
      DUF4619; Domain of unknown function (DUF4619)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CPZ1.3 GenPept UniProtKB/Swiss-Prot:Q9CPZ1

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