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    CG16790 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41155, updated on 10-May-2024

    Summary

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    Official Symbol
    CG16790provided by FlyBase
    Primary source
    FLYBASE:FBgn0037713
    Locus tag
    Dmel_CG16790
    See related
    AllianceGenome:FB:FBgn0037713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG16790
    Summary
    Predicted to enable 3'-5'-exoribonuclease activity. Predicted to be involved in U6 snRNA 3'-end processing. Predicted to be active in nucleus. Is expressed in adult head. Human ortholog(s) of this gene implicated in poikiloderma with neutropenia. Orthologous to human USB1 (U6 snRNA biogenesis phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG16790 in Genome Data Viewer
    Location:
    85D25-85D25; 3-48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (9569074..9570214, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5394796..5395936, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 45 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Kim MS, et al. Nat Immunol, 2003 Aug. PMID 12845326
    2. Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Baeg GH, et al. Genes Dev, 2005 Aug 15. PMID 16055650, Free PMC Article
    3. Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. Colca JR, et al. PLoS One, 2013. PMID 23690925, Free PMC Article
    4. Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. Mazumder R, et al. Nucleic Acids Res, 2002 Dec 1. PMID 12466548, Free PMC Article
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in U6 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in U6 snRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG16790-PA
    CG16790-PB
    NP_001262424.1
    NP_649911.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      9569074..9570214 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275495.1 → NP_001262424.1  uncharacterized protein Dmel_CG16790, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFH3

    2. NM_141654.2 → NP_649911.1  uncharacterized protein Dmel_CG16790, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649911.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4QQ73, Q4QQ86, Q9VHB3
      UniProtKB/TrEMBL
      B5X522
      Related
      FBpp0081590
      Conserved Domains (1) summary
      pfam09749
      Location:34 → 254
      HVSL; uncharacterized conserved protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFH3 A0A0B4KFH3
    Q9VHB3.1 Q9VHB3

    Gene LinkOut

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