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    kirre kin of irre [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31292, updated on 10-May-2024

    Summary

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    Official Symbol
    kirreprovided by FlyBase
    Official Full Name
    kin of irreprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028369
    Locus tag
    Dmel_CG3653
    See related
    AllianceGenome:FB:FBgn0028369
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3653; CT12279; Dmel\CG3653; dNeph; duf; Duf; DUF; duf/kirre; Duf/Kirre; DUF/KIRRE; EG:163A10.1; Kirre; Neph1; RH09239
    Summary
    Enables cell adhesion molecule binding activity. Involved in several processes, including garland nephrocyte differentiation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and sensory organ development. Located in apical plasma membrane and nephrocyte diaphragm. Is integral component of plasma membrane. Colocalizes with cell-cell junction. Is expressed in several structures, including dorsal pharyngeal muscle anlage; extended germ band embryo; head; muscle system; and nephrocyte. Used to study kidney disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 4 and nephrotic syndrome type 23. Orthologous to human KIRREL1 (kirre like nephrin family adhesion molecule 1); KIRREL2 (kirre like nephrin family adhesion molecule 2); and KIRREL3 (kirre like nephrin family adhesion molecule 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See kirre in Genome Data Viewer
    Location:
    3B4-3C7; 1-2 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2740384..3134532)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2634417..3028565)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43494 Neighboring gene uncharacterized protein Neighboring gene tiny tim 50 Neighboring gene Syntaxin 4 Neighboring gene cramped Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene white Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene roughest Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Notch

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The irre cell recognition module (IRM) protein Kirre is required to form the reciprocal synaptic network of L4 neurons in the Drosophila lamina. Lüthy K, et al. J Neurogenet, 2014 Sep-Dec. PMID 24697410
    2. Experimental Models to Study Podocyte Biology: Stock-Taking the Toolbox of Glomerular Research. Hagmann H, et al. Front Pediatr, 2018. PMID 30057894, Free PMC Article
    3. [Chromatin decompaction in the interbands of Drosophila polytene chromosomes does not correlate with high transcription level]. Kvon EZ, et al. Genetika, 2011 Jun. PMID 21866857
    4. rst transcriptional activity influences kirre mRNA concentration in the Drosophila pupal retina during the final steps of ommatidial patterning. Machado MC, et al. PLoS One, 2011. PMID 21857931, Free PMC Article
    5. The decompact state of interchromomeric chromatin from the 3C6/C7 region of Drosophila melanogaster is determined by short DNA sequence. Andreyenkov OV, et al. Dokl Biochem Biophys, 2010 Mar-Apr. PMID 20514862

    See all (227) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results uncover a significant but hitherto uncharacterized involvement of IRM components Hbs, Kirre, and specially Rst in ovarian development
      Title: Expression of Hbs, Kirre, and Rst during Drosophila ovarian development.
    2. the roles of Rst, Hbs, Kirre and SNS in the spacing of bristles of the anterior wing margin, are explored.
      Title: The Cell Adhesion Molecules Roughest, Hibris, Kin of Irre and Sticks and Stones Are Required for Long Range Spacing of the Drosophila Wing Disc Sensory Sensilla.
    3. removing Kirre protein specifically disrupts the functional L4 synaptic network in the Drosophila lamina.
      Title: The irre cell recognition module (IRM) protein Kirre is required to form the reciprocal synaptic network of L4 neurons in the Drosophila lamina.
    4. Dumbfounded/Neph1, a key diaphragm constituent, is a target of the Src kinase Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 tyrosine phosphorylation.
      Title: Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies.
    5. Analysis of a cytoplasmic motif present in Kirre and IrreC/Rst revealed a functionally required, conserved 12 AA motif (KIN1 motif).
      Title: Functional study of mammalian Neph proteins in Drosophila melanogaster.
    6. Dumbfounded and Sticks and Stones are expressed in the genital imaginal disc and in the muscle sheath of the testes during muscle differentiation.
      Title: Multinucleated smooth muscles and mononucleated as well as multinucleated striated muscles develop during establishment of the male reproductive organs of Drosophila melanogaster.
    7. Findings suggest a general mechanism by which rst and kirre expression could be fine tuned to optimize their redundant roles during development.
      Title: rst transcriptional activity influences kirre mRNA concentration in the Drosophila pupal retina during the final steps of ommatidial patterning.
    8. Results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf.
      Title: The intracellular domain of Dumbfounded affects myoblast fusion efficiency and interacts with Rolling pebbles and Loner.
    9. analysis of the spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre
      Title: The complex spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre.
    10. Kirre and Sns are co-expressed within binucleate garland cell nephrocytes that contribute to detoxification of hemolymph by uptake of molecules through a slit diaphragm-like nephrocyte diaphragm into labyrinthine channels that are sites of endocytosis.
      Title: Sns and Kirre, the Drosophila orthologs of Nephrin and Neph1, direct adhesion, fusion and formation of a slit diaphragm-like structure in insect nephrocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 3075689-3080937 mobile_element_type = transposon:Transpac{}32

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaeta morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in filtration diaphragm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in garland nephrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval visceral muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nephrocyte diaphragm assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nephrocyte filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of striated muscle tissue development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nephrocyte diaphragm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kin of irre
    Names
    CG3653-PA
    CG3653-PB
    CG3653-PC
    CG3653-PD
    CG3653-PE
    CG3653-PF
    CG3653-PG
    Dumbfounded/Kirre
    Kin of irre
    Kin of irregular-chiasm-C
    Kin-of-irre
    dumbfounded
    kin of irreC
    kin-of-irreC
    kirre
    kirre-PA
    kirre-PB
    kirre-PC
    kirre-PD
    kirre-PE
    kirre-PF
    kirre-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2740384..3134532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258578.1 → NP_001245507.1  kin of irre, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245507.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain

    2. NM_001258579.3 → NP_001245508.1  kin of irre, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245508.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain

    3. NM_080320.4 → NP_525059.2  kin of irre, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525059.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Related
      FBpp0070534
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain

    4. NM_001272267.1 → NP_001259196.1  kin of irre, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain

    5. NM_001258576.1 → NP_001245505.1  kin of irre, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245505.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain

    6. NM_001258577.1 → NP_001245506.1  kin of irre, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245506.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain

    7. NM_166958.2 → NP_726844.1  kin of irre, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726844.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N9Y9, Q9NCP3, Q9W4T9
      Related
      FBpp0070535
      Conserved Domains (6) summary
      smart00408
      Location:396 → 446
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:88 → 182
      IG_like; Immunoglobulin like
      pfam07679
      Location:382 → 462
      I-set; Immunoglobulin I-set domain
      pfam08205
      Location:189 → 279
      C2-set_2; CD80-like C2-set immunoglobulin domain
      pfam13895
      Location:307 → 379
      Ig_2; Immunoglobulin domain
      cl11960
      Location:466 → 561
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O97174 O97174
    Q8MSN7 Q8MSN7
    Q9N9Y9 Q9N9Y9
    Q9W4T9 Q9W4T9

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