ALG13 ALG13 UDP-N-acetylglucosaminyltransferase subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: ALG13provided by HGNC
Official Full Name: ALG13 UDP-N-acetylglucosaminyltransferase subunitprovided by HGNC
Primary source: HGNC:HGNC:30881
See related: Ensembl:ENSG00000101901 MIM:300776; AllianceGenome:HGNC:30881
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDG1S; DEE36; EIEE36; MDS031; TDRD13; CXorf45; GLT28D1; YGL047W
Summary: The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression: Ubiquitous expression in testis (RPKM 4.1), skin (RPKM 3.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq23

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (111681170..111760649)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (110129414..110208990)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (110924398..111003877)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ALG13 X-linked intellectual disability: New variants, glycosylation analysis, and expanded phenotypes.
Title: ALG13 X-linked intellectual disability: New variants, glycosylation analysis, and expanded phenotypes.
Expanding the phenotype, genotype and biochemical knowledge of ALG3-CDG.
Title: Expanding the phenotype, genotype and biochemical knowledge of ALG3-CDG.
The phenotypic spectrum of X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy.
Title: The phenotypic spectrum of X-linked, infantile onset ALG13-related developmental and epileptic encephalopathy.
X-Linked ALG13 Gene Variant as a Cause of Epileptic Encephalopathy in Girls.
Title: X-Linked ALG13 Gene Variant as a Cause of Epileptic Encephalopathy in Girls.
ALG13-is2 could be an important modifier of renal filtration defects
Title: Dysregulation of the Expression of Asparagine-Linked Glycosylation 13 Short Isoform 2 Affects Nephrin Function by Altering Its N-Linked Glycosylation.
A female patient heterozygous for ALG13 Asn107Ser variant presented with infantile spasms, developmental delay, and dysmorphic features. The patient showed normal pattern of glycosylated transferrin and random pattern of X-inactivation.
Title: Exome sequence identified a c.320A > G ALG13 variant in a female with infantile epileptic encephalopathy with normal glycosylation and random X inactivation: Review of the literature.
We report on a novel missense variant in the ALG13 gene in a nonconsanguineous Arab family that co-segregates with nonsyndromic intellectual disability.
Title: X chromosome exome sequencing reveals a novel ALG13 mutation in a nonsyndromic intellectual disability family with multiple affected male siblings.
ALG13 and ALG14 form a functional endoplasmic reticulum UDP-N-acetylglucosamine transferase
Title: Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital disorder of glycosylation MedGen: C0282577 GeneReviews: Congenital Disorders of N-Linked Glycosylation and Multiple Pathway Overview	not available
Developmental and epileptic encephalopathy, 36 MedGen: C4317295 OMIM: 300884 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Addition of peripheral sugar residues such as galactose, N-acetylglucosamine, and sialic acid to HIV-1 gp120 is processed by specific glycosyltransferase	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-14094 (e-PCR)
- UniSTS:62726

RH121691 (e-PCR)
- UniSTS:134430

RH93842 (e-PCR)
- UniSTS:85560

SHGC-16527 (e-PCR)
- UniSTS:18761

NoName (e-PCR)
- UniSTS:490317

AL035135 (e-PCR)
- UniSTS:94645

DXS7012E (e-PCR)
- UniSTS:99254

NoName (e-PCR)
- UniSTS:99323

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
NOT enables cysteine-type deubiquitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
NOT part_of UDP-N-acetylglucosamine transferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of UDP-N-acetylglucosamine transferase complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic side of endoplasmic reticulum membrane	IGI Inferred from Genetic Interaction more info	PubMed
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: UDP-N-acetylglucosamine transferase subunit ALG13

Names: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase; UDP-N-acetylglucosamine transferase subunit ALG13 homolog; asparagine-linked glycosylation 13 homolog; glycosyltransferase 28 domain-containing protein 1; hematopoietic stem/progenitor cells protein MDS031; putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13; tudor domain containing 13

NP_001034299.3

EC 2.4.1.141

NP_001093392.1

EC 2.4.1.141

NP_001161857.1

EC 2.4.1.141

NP_001244159.1

EC 2.4.1.141

NP_001244160.1

EC 2.4.1.141

NP_001244163.1

EC 2.4.1.141

NP_001244164.1

EC 2.4.1.141

NP_001244166.1

EC 2.4.1.141

NP_001244168.1

EC 2.4.1.141

NP_001244169.1

EC 2.4.1.141

NP_001244170.1

EC 2.4.1.141

NP_001311219.1

EC 2.4.1.141

NP_001311220.1

EC 2.4.1.141

NP_001311221.1

EC 2.4.1.141

NP_001311222.1

EC 2.4.1.141

NP_001311223.1

EC 2.4.1.141

NP_060936.1

EC 2.4.1.141

XP_006724756.1

EC 2.4.1.141

XP_006724760.2

EC 2.4.1.141

XP_006724761.2

EC 2.4.1.141

XP_011529330.1

EC 2.4.1.141

XP_011529332.1

EC 2.4.1.141

XP_011529333.1

EC 2.4.1.141

XP_011529334.1

EC 2.4.1.141

XP_011529335.1

EC 2.4.1.141

XP_011529336.1

EC 2.4.1.141

XP_016885335.1

EC 2.4.1.141

XP_016885336.1

EC 2.4.1.141

XP_016885337.1

EC 2.4.1.141

XP_016885338.1

EC 2.4.1.141

XP_016885339.1

EC 2.4.1.141

XP_016885341.1

EC 2.4.1.141

XP_024308217.1

EC 2.4.1.141

XP_047298476.1

EC 2.4.1.141

XP_047298477.1

EC 2.4.1.141

XP_047298478.1

EC 2.4.1.141

XP_047298479.1

EC 2.4.1.141

XP_047298480.1

EC 2.4.1.141

XP_047298481.1

EC 2.4.1.141

XP_047298482.1

EC 2.4.1.141

XP_047298483.1

EC 2.4.1.141

XP_047298484.1

EC 2.4.1.141

XP_047298485.1

EC 2.4.1.141

XP_047298486.1

EC 2.4.1.141

XP_047298487.1

EC 2.4.1.141

XP_054183853.1

EC 2.4.1.141

XP_054183854.1

EC 2.4.1.141

XP_054183855.1

EC 2.4.1.141

XP_054183856.1

EC 2.4.1.141

XP_054183857.1

EC 2.4.1.141

XP_054183858.1

EC 2.4.1.141

XP_054183859.1

EC 2.4.1.141

XP_054183860.1

EC 2.4.1.141

XP_054183861.1

EC 2.4.1.141

XP_054183862.1

EC 2.4.1.141

XP_054183863.1

EC 2.4.1.141

XP_054183864.1

EC 2.4.1.141

XP_054183865.1

EC 2.4.1.141

XP_054183866.1

EC 2.4.1.141

XP_054183867.1

EC 2.4.1.141

XP_054183868.1

EC 2.4.1.141

XP_054183869.1

EC 2.4.1.141

XP_054183870.1

EC 2.4.1.141

XP_054183871.1

EC 2.4.1.141

XP_054183872.1

EC 2.4.1.141

XP_054183873.1

EC 2.4.1.141

XP_054183874.1

EC 2.4.1.141

XP_054183875.1

EC 2.4.1.141

XP_054183876.1

EC 2.4.1.141

XP_054183877.1

EC 2.4.1.141

XP_054183878.1

EC 2.4.1.141

XP_054183879.1

EC 2.4.1.141

XP_054183880.1

EC 2.4.1.141

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016238.1 RefSeqGene

Range

5053..84532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001039210.5 → NP_001034299.3 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 3

See identical proteins and their annotated locations for NP_001034299.3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' UTR and has multiple differences in the coding region, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK056347, AL096764, BC005336, BF699152, BQ007420

UniProtKB/TrEMBL

A0A096LNL2

Conserved Domains (1) summary

cl10013
Location:4 → 48

Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
NM_001099922.3 → NP_001093392.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 1

See identical proteins and their annotated locations for NP_001093392.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK302729, AK304712, BF699152, BQ015240, DB516751

Consensus CDS

CCDS55477.1

UniProtKB/Swiss-Prot

B1AKD6, B1AKM1, B2R5L5, B7Z6J0, B7Z804, B7Z847, B7Z9A8, B7ZAJ1, B7ZB57, Q17RC3, Q5JXY9, Q9H5U8, Q9NP73

UniProtKB/TrEMBL

A0A096LPI3

Related

ENSP00000378260.3, ENST00000394780.8

Conserved Domains (3) summary

cd04508
Location:496 → 544

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:239 → 345

OTU; OTU-like cysteine protease
NM_001168385.3 → NP_001161857.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 4

See identical proteins and their annotated locations for NP_001161857.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (4) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK056347, AL096764, BC005336, BE747995, BF699152

Consensus CDS

CCDS76011.1

UniProtKB/TrEMBL

A0A087WX43, A0A096LNJ4

Related

ENSP00000480711.1, ENST00000473389.5

Conserved Domains (1) summary

cl10013
Location:4 → 131

Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
NM_001257230.2 → NP_001244159.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 5

See identical proteins and their annotated locations for NP_001244159.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate splice site in the 5' region, initiates translation at a downstream, in-frame start codon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.

Source sequence(s)

AK026671, AK300394, AK316522, BF699152, BQ015240

Consensus CDS

CCDS59173.1

UniProtKB/TrEMBL

A0A096LPI3

Related

ENSP00000392990.2, ENST00000436609.5

Conserved Domains (2) summary

cd04508
Location:392 → 440

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
NM_001257231.2 → NP_001244160.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 6

See identical proteins and their annotated locations for NP_001244160.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR, initiates translation at an alternate start codon and uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (6) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK026671, AK302890, BP344481, BQ015240, DB292609

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (3) summary

cd04508
Location:418 → 466

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 42

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:161 → 267

OTU; OTU-like cysteine protease
NM_001257234.2 → NP_001244163.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 5

See identical proteins and their annotated locations for NP_001244163.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon. Variants 5, 8 and 10 encode the same isoform (5), which is shorter than isoform 1.

Source sequence(s)

AK026671, AK316306, AK316522, BQ015240, DB292609

Consensus CDS

CCDS59173.1

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd04508
Location:392 → 440

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
NM_001257235.3 → NP_001244164.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 7

See identical proteins and their annotated locations for NP_001244164.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon and alternate 3' UTR. Variants 9, 11 and 12 encode the same isoform (7) which is significantly shorter and has a unique C-terminus, compared to isoform 1.

Source sequence(s)

AL096764, CB268871, DB292609

Consensus CDS

CCDS76013.1

UniProtKB/TrEMBL

A0A087WT15
NM_001257237.2 → NP_001244166.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 5

See identical proteins and their annotated locations for NP_001244166.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. Variants 5, 8 and 10 encode the same isoform (5), which is shorter than isoform 1.

Source sequence(s)

AK026671, AK316522, BQ015240, DB292609

Consensus CDS

CCDS59173.1

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd04508
Location:392 → 440

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
NM_001257239.3 → NP_001244168.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 7

See identical proteins and their annotated locations for NP_001244168.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon and alternate 3' UTR. Variants 9, 11 and 12 encode the same isoform (7) which is significantly shorter and has a unique C-terminus, compared to isoform 1.

Source sequence(s)

AL096764, BG621042, BM759764, DC400909

Consensus CDS

CCDS76013.1

UniProtKB/TrEMBL

A0A087WT15

Related

ENSP00000477513.1, ENST00000482742.5

Conserved Domains (1) summary

COG0008
Location:7 → 24

GlnS; Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]
NM_001257240.3 → NP_001244169.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 7

See identical proteins and their annotated locations for NP_001244169.1

Status: REVIEWED

Description

Transcript Variant: This variant (12) has multiple differences, compared to variant 1, including the use of a downstream, in-frame start codon and alternate 3' UTR. Variants 9, 11 and 12 encode the same isoform (7) which is significantly shorter and has a unique C-terminus, compared to isoform 1.

Source sequence(s)

AL096764, DB292609, DN992019

Consensus CDS

CCDS76013.1

UniProtKB/TrEMBL

A0A087WT15

Conserved Domains (1) summary

COG0008
Location:7 → 24

GlnS; Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]
NM_001257241.3 → NP_001244170.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 8

See identical proteins and their annotated locations for NP_001244170.1

Status: REVIEWED

Description

Transcript Variant: This variant (13) has multiple differences, compared to variant 1, including the use of an alternate start codon and alternate 3' UTR. The encoded isoform (8) is shorter and has distinct N- and C-termini, compared to isoform 1.

Source sequence(s)

AK302890, AL096764, BF239206, DB292609

UniProtKB/Swiss-Prot

Q9NP73

Conserved Domains (1) summary

cl10013
Location:4 → 42

Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology
NM_001324290.2 → NP_001311219.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 9

Status: REVIEWED

Source sequence(s)

AL096764

UniProtKB/TrEMBL

A0A096LP10

Related

ENSP00000485333.1, ENST00000623255.1
NM_001324291.2 → NP_001311220.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 7

Status: REVIEWED

Source sequence(s)

AL096764

Consensus CDS

CCDS76013.1

UniProtKB/TrEMBL

A0A087WT15
NM_001324292.2 → NP_001311221.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 10

Status: REVIEWED

Source sequence(s)

AL049563, AL096764

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (3) summary

cd04508
Location:496 → 544

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:239 → 345

OTU; OTU-like cysteine protease
NM_001324293.1 → NP_001311222.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 11

Status: REVIEWED

Source sequence(s)

AL049563, AL096764

UniProtKB/TrEMBL

A0A096LPI3

Related

ENSP00000485624.2, ENST00000623622.2
NM_001324294.2 → NP_001311223.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 7

Status: REVIEWED

Source sequence(s)

AL096764

Consensus CDS

CCDS76013.1

UniProtKB/TrEMBL

A0A087WT15

Related

ENSP00000485392.1, ENST00000623189.1
NM_018466.6 → NP_060936.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform 2

See identical proteins and their annotated locations for NP_060936.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks a large portion of the 3' coding region and uses an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

AK056347, AL096764, BC005336, BF699152

Consensus CDS

CCDS14559.1

UniProtKB/TrEMBL

A0A096LP10

Related

ENSP00000361047.3, ENST00000371979.7

Conserved Domains (1) summary

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

RNA

NR_033125.3 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because use of the downstream start codon used in variant 5 results in a short ORF that does not meet RefSeq criteria.

Source sequence(s)

AK056347, AL096764, AL524204, BC005336, BE747995, BF699152
NR_136735.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) has multiple differences, compared to variant 1. This variant is represented as non-coding because use of the downstream start codon used in variant 5 results in a short ORF that does not meet RefSeq criteria.

Source sequence(s)

AL096764
NR_148693.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL049563, AL096764

Related

ENST00000636363.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

111681170..111760649

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011531031.2 → XP_011529333.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9

See identical proteins and their annotated locations for XP_011529333.1

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd20447
Location:384 → 463

Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
XM_006724698.4 → XP_006724761.2 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9

See identical proteins and their annotated locations for XP_006724761.2

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd20447
Location:384 → 463

Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
XM_011531028.3 → XP_011529330.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X1

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (3) summary

cd04508
Location:496 → 544

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:239 → 345

OTU; OTU-like cysteine protease
XM_011531030.3 → XP_011529332.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X7

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (3) summary

cd04508
Location:496 → 544

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:239 → 345

OTU; OTU-like cysteine protease
XM_017029847.2 → XP_016885336.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X3

UniProtKB/TrEMBL

A0A096LPI3
XM_006724693.4 → XP_006724756.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X5

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (3) summary

cd04508
Location:496 → 544

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:239 → 345

OTU; OTU-like cysteine protease
XM_047442523.1 → XP_047298479.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X11
XM_017029846.2 → XP_016885335.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X2

UniProtKB/TrEMBL

A0A096LPI3
XM_047442520.1 → XP_047298476.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X4
XM_017029848.2 → XP_016885337.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X10

UniProtKB/TrEMBL

A0A096LPI3
XM_047442521.1 → XP_047298477.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X6
XM_047442522.1 → XP_047298478.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X8
XM_047442525.1 → XP_047298481.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X13
XM_006724697.4 → XP_006724760.2 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9

See identical proteins and their annotated locations for XP_006724760.2

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd20447
Location:384 → 463

Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
XM_017029850.3 → XP_016885339.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X16

UniProtKB/TrEMBL

A0A096LPI3
XM_017029849.2 → XP_016885338.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X15

UniProtKB/TrEMBL

A0A096LPI3
XM_024452449.2 → XP_024308217.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X17

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (3) summary

cd04508
Location:496 → 544

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl10013
Location:4 → 120

Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

cl19932
Location:239 → 345

OTU; OTU-like cysteine protease
XM_011531033.4 → XP_011529335.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9

See identical proteins and their annotated locations for XP_011529335.1

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd20447
Location:384 → 463

Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
XM_011531032.2 → XP_011529334.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9

See identical proteins and their annotated locations for XP_011529334.1

UniProtKB/TrEMBL

A0A096LPI3

Conserved Domains (2) summary

cd20447
Location:384 → 463

Tudor_TDRD13; Tudor domain found in Tudor domain-containing protein 13 (TDRD13)

cl19932
Location:135 → 241

OTU; OTU-like cysteine protease
XM_047442524.1 → XP_047298480.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X12
XM_011531034.3 → XP_011529336.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X14

Conserved Domains (2) summary

cd04508
Location:293 → 341

TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

cl19932
Location:36 → 142

OTU; OTU-like cysteine protease
XM_047442526.1 → XP_047298482.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X18
XM_047442528.1 → XP_047298484.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X21
XM_047442529.1 → XP_047298485.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X22
XM_047442527.1 → XP_047298483.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X20
XM_017029852.2 → XP_016885341.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X19
XM_047442531.1 → XP_047298487.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X24
XM_047442530.1 → XP_047298486.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X23

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

110129414..110208990

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054327894.1 → XP_054183869.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9
XM_054327888.1 → XP_054183863.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9
XM_054327878.1 → XP_054183853.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X1
XM_054327884.1 → XP_054183859.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X7
XM_054327880.1 → XP_054183855.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X3
XM_054327882.1 → XP_054183857.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X5
XM_054327891.1 → XP_054183866.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X11
XM_054327879.1 → XP_054183854.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X2
XM_054327881.1 → XP_054183856.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X4
XM_054327890.1 → XP_054183865.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X10
XM_054327883.1 → XP_054183858.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X6
XM_054327885.1 → XP_054183860.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X8
XM_054327893.1 → XP_054183868.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X13
XM_054327889.1 → XP_054183864.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9
XM_054327897.1 → XP_054183872.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X16
XM_054327896.1 → XP_054183871.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X15
XM_054327898.1 → XP_054183873.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X17
XM_054327886.1 → XP_054183861.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9
XM_054327887.1 → XP_054183862.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X9
XM_054327892.1 → XP_054183867.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X12
XM_054327895.1 → XP_054183870.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X14
XM_054327899.1 → XP_054183874.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X18
XM_054327902.1 → XP_054183877.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X21
XM_054327903.1 → XP_054183878.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X22
XM_054327901.1 → XP_054183876.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X20
XM_054327900.1 → XP_054183875.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X19
XM_054327905.1 → XP_054183880.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X24
XM_054327904.1 → XP_054183879.1 UDP-N-acetylglucosamine transferase subunit ALG13 isoform X23

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_024810.1: Suppressed sequence

Description

NM_024810.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.