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    ABI2 abl interactor 2 [ Homo sapiens (human) ]

    Gene ID: 10152, updated on 14-Nov-2024

    Summary

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    Official Symbol
    ABI2provided by HGNC
    Official Full Name
    abl interactor 2provided by HGNC
    Primary source
    HGNC:HGNC:24011
    See related
    Ensembl:ENSG00000138443 MIM:606442; AllianceGenome:HGNC:24011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB
    Summary
    Enables several functions, including SH3 domain binding activity; proline-rich region binding activity; and ubiquitin protein ligase binding activity. Contributes to small GTPase binding activity. Involved in several processes, including Rac protein signal transduction; positive regulation of cellular component organization; and zonula adherens assembly. Acts upstream of or within peptidyl-tyrosine phosphorylation. Located in several cellular components, including actin filament; filopodium tip; and lamellipodium. Part of SCAR complex. Is active in adherens junction. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in brain (RPKM 35.9), thyroid (RPKM 13.9) and 21 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ABI2 in Genome Data Viewer
    Location:
    2q33.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (203328394..203432169)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (203810332..203914077)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (204193117..204296892)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 20 subfamily A member 1 Neighboring gene RNA, 7SL, cytoplasmic 670, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:204192004-204192974 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12255 Neighboring gene mitochondrial ribosomal protein L50 pseudogene 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:204209822-204210322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17011 Neighboring gene MPRA-validated peak4020 silencer Neighboring gene tRNA-Glu (anticodon TTC) 9-1 Neighboring gene Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12256 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12258 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:204464991-204465874 Neighboring gene zinc finger protein 207 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of ArgBP1, an Arg protein tyrosine kinase binding protein that is the human homologue of a CNS-specific Xenopus gene. Wang B, et al. Oncogene, 1996 May 2. PMID 8649853
    2. Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway. Li Y, et al. J Cell Sci, 2007 Apr 15. PMID 17389688, Free PMC Article
    3. The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta. Luo X, et al. Hum Reprod, 2006 Jun. PMID 16488906
    4. Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study. Ergun S, et al. Int J Exp Pathol, 2020 Jun. PMID 32496656, Free PMC Article
    5. Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia. Coenen EA, et al. Leuk Res, 2012 May. PMID 22304832

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC.
      Title: The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties and tumorigenesis in HCC.
    2. PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.
      Title: PIM1 phosphorylates ABI2 to enhance actin dynamics and promote tumor invasion.
    3. Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.
      Title: Association of Abl interactor 2, ABI2, with platelet/lymphocyte ratio in patients with renal cell carcinoma: A pilot study.
    4. TIS21 attenuated Doxorubicin-induced cancer cell senescence by inhibiting linear actin nucleation via Nox4-ROS-ABI2-DRF signal cascade
      Title: TIS21(/BTG2) inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.
    5. Abl-interactor 2 (ABI2) is a novel MLL translocation partner in acute myeloid leukemia.
      Title: Abl-interactor 2 (ABI2): a novel MLL translocation partner in acute myeloid leukemia.
    6. These findings uncover a novel link between cadherin-mediated adhesion and the regulation of actin dynamics through the requirement for an Abi/Dia complex for the formation and stability of cell-cell junctions.
      Title: Regulation of cell-cell adhesion by Abi/Diaphanous complexes.
    7. TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs via degradation of Abl-interactor 2
      Title: Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
    8. disruption of the interaction between Bcr-Abl and Abi1 by mutations either in Bcr-Abl or Abi1 not only abolished tyrosine phosphorylation of Abi1 and membrane translocation of Abi1/WAVE2
      Title: Bcr-Abl induces abnormal cytoskeleton remodeling, beta1 integrin clustering and increased cell adhesion to fibronectin through the Abl interactor 1 pathway.
    9. Abi-2 may have a key regulatory function in leiomyomas cellular/tissue structural organization during growth and regression
      Title: The expression of Abl interactor 2 in leiomyoma and myometrium and regulation by GnRH analogue and transforming growth factor-beta.
    10. NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.
      Title: NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
    EBI GWAS Catalog
    GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables SH3 domain binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cytoskeletal anchor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables proline-rich region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Rac protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin polymerization or depolymerization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell migration TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in lens fiber cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in zonula adherens assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in filopodium tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    abl interactor 2
    Names
    abelson interactor 2
    abl binding protein 3
    abl-interacting protein 1 (SH3-containing protein)
    abl-interactor protein 2b
    arg protein tyrosine kinase-binding protein
    arg-binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282925.3 → NP_001269854.1  abl interactor 2 isoform a

      See identical proteins and their annotated locations for NP_001269854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AC018891, AC080075
      Consensus CDS
      CCDS63093.1
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      UniProtKB/TrEMBL
      A0A7D9NKC8
      Related
      ENSP00000295851.4, ENST00000295851.10
      Conserved Domains (3) summary
      cd11972
      Location:452 → 512
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:270 → 397
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    2. NM_001282926.3 → NP_001269855.1  abl interactor 2 isoform b

      See identical proteins and their annotated locations for NP_001269855.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AC018891, AC080075
      Consensus CDS
      CCDS63094.1
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      UniProtKB/TrEMBL
      A0A0C4DG21
      Related
      ENSP00000391433.1, ENST00000424558.5
      Conserved Domains (3) summary
      cd11972
      Location:446 → 506
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:264 → 391
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    3. NM_001282927.2 → NP_001269856.1  abl interactor 2 isoform d

      See identical proteins and their annotated locations for NP_001269856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, differs in the presence and absence of exons in the 5' coding region, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a. Variants 4 and 6 both encode the same isoform (d).
      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      Q9NYB9
      Conserved Domains (2) summary
      cd11972
      Location:340 → 400
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:48 → 118
      Abi_HHR; Abl-interactor HHR

    4. NM_001282932.2 → NP_001269861.1  abl interactor 2 isoform e

      See identical proteins and their annotated locations for NP_001269861.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR, differs in the presence and absence of exons in the 5' coding region, initiates translation at an alternate start codon, and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (e) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      B7Z836, E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:329 → 389
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:37 → 107
      Abi_HHR; Abl-interactor HHR

    5. NM_001375662.1 → NP_001362591.1  abl interactor 2 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 8, encodes isoform f.
      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      B7Z612
      Conserved Domains (3) summary
      cd11972
      Location:407 → 467
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:196 → 332
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    6. NM_001375663.1 → NP_001362592.1  abl interactor 2 isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 7, encodes isoform f.
      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      B7Z612
      Conserved Domains (3) summary
      cd11972
      Location:407 → 467
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:196 → 332
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    7. NM_001375664.1 → NP_001362593.1  abl interactor 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:329 → 389
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:147 → 274
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    8. NM_001375665.1 → NP_001362594.1  abl interactor 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:329 → 389
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:147 → 274
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    9. NM_001375666.1 → NP_001362595.1  abl interactor 2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 12, encodes isoform h.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:311 → 371
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    10. NM_001375667.1 → NP_001362596.1  abl interactor 2 isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12), as well as variant 11, encodes isoform h.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:311 → 371
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    11. NM_001375668.1 → NP_001362597.1  abl interactor 2 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variant 14, encodes isoform i.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:291 → 351
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    12. NM_001375669.1 → NP_001362598.1  abl interactor 2 isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variant 13, encodes isoform i.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:291 → 351
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    13. NM_001375670.1 → NP_001362599.1  abl interactor 2 isoform j

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) encodes the longest isoform (j).
      Source sequence(s)
      AC018891, AC080075
      Consensus CDS
      CCDS92932.1
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      UniProtKB/TrEMBL
      F8WAL6, J3KNB2
      Related
      ENSP00000261018.9, ENST00000261018.12
      Conserved Domains (3) summary
      cd11972
      Location:481 → 541
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:270 → 406
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    14. NM_001375671.1 → NP_001362600.1  abl interactor 2 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:480 → 540
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:269 → 405
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    15. NM_001375672.1 → NP_001362601.1  abl interactor 2 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EP65
      Conserved Domains (3) summary
      PHA03247
      Location:270 → 406
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:481 → 515
      SH3; Src Homology 3 domain superfamily

    16. NM_001375673.1 → NP_001362602.1  abl interactor 2 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:479 → 539
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:270 → 406
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    17. NM_001375674.1 → NP_001362603.1  abl interactor 2 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EP65
      Conserved Domains (3) summary
      PHA03247
      Location:269 → 405
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:480 → 514
      SH3; Src Homology 3 domain superfamily

    18. NM_001375675.1 → NP_001362604.1  abl interactor 2 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:475 → 535
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:264 → 400
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    19. NM_001375676.1 → NP_001362605.1  abl interactor 2 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      PHA03247
      Location:270 → 399
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 169
      Abi_HHR; Abl-interactor HHR

    20. NM_001375677.1 → NP_001362606.1  abl interactor 2 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:451 → 511
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:269 → 396
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    21. NM_001375678.1 → NP_001362607.1  abl interactor 2 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:447 → 507
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:221 → 351
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 169
      Abi_HHR; Abl-interactor HHR

    22. NM_001375679.1 → NP_001362608.1  abl interactor 2 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:436 → 496
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:225 → 361
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:48 → 124
      Abi_HHR; Abl-interactor HHR

    23. NM_001375680.1 → NP_001362609.1  abl interactor 2 isoform t

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:432 → 492
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:221 → 357
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    24. NM_001375681.1 → NP_001362610.1  abl interactor 2 isoform u

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:431 → 491
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:220 → 356
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    25. NM_001375682.1 → NP_001362611.1  abl interactor 2 isoform v

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:430 → 490
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:221 → 357
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    26. NM_001375683.1 → NP_001362612.1  abl interactor 2 isoform w

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:426 → 486
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:215 → 351
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    27. NM_001375684.1 → NP_001362613.1  abl interactor 2 isoform x

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:425 → 485
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:214 → 350
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    28. NM_001375685.1 → NP_001362614.1  abl interactor 2 isoform y

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:418 → 478
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:221 → 351
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    29. NM_001375686.1 → NP_001362615.1  abl interactor 2 isoform z

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:414 → 448
      SH3; Src Homology 3 domain superfamily

    30. NM_001375687.1 → NP_001362616.1  abl interactor 2 isoform aa

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:413 → 473
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    31. NM_001375688.1 → NP_001362617.1  abl interactor 2 isoform bb

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:412 → 472
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    32. NM_001375689.1 → NP_001362618.1  abl interactor 2 isoform cc

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:413 → 447
      SH3; Src Homology 3 domain superfamily

    33. NM_001375690.1 → NP_001362619.1  abl interactor 2 isoform dd

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:411 → 471
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    34. NM_001375691.1 → NP_001362620.1  abl interactor 2 isoform ee

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:407 → 467
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:225 → 352
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:48 → 124
      Abi_HHR; Abl-interactor HHR

    35. NM_001375692.1 → NP_001362621.1  abl interactor 2 isoform ff

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:403 → 463
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:221 → 348
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    36. NM_001375693.1 → NP_001362622.1  abl interactor 2 isoform gg

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:402 → 462
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:220 → 347
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    37. NM_001375695.1 → NP_001362624.1  abl interactor 2 isoform hh

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      B7Z612
      Conserved Domains (3) summary
      cd11972
      Location:401 → 461
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:190 → 326
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    38. NM_001375696.1 → NP_001362625.1  abl interactor 2 isoform ii

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:400 → 460
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 163
      Abi_HHR; Abl-interactor HHR

    39. NM_001375698.1 → NP_001362627.1  abl interactor 2 isoform jj

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Consensus CDS
      CCDS92933.1
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      UniProtKB/TrEMBL
      E9PEZ7
      Related
      ENSP00000408898.1, ENST00000430418.5
      Conserved Domains (3) summary
      cd11972
      Location:397 → 457
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:215 → 342
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    40. NM_001375699.1 → NP_001362628.1  abl interactor 2 isoform kk

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:396 → 456
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:214 → 341
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    41. NM_001375702.1 → NP_001362631.1  abl interactor 2 isoform ll

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:396 → 456
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:214 → 341
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    42. NM_001375704.1 → NP_001362633.1  abl interactor 2 isoform mm

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 163
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:414 → 449
      SH3; Src Homology 3 domain superfamily

    43. NM_001375706.1 → NP_001362635.1  abl interactor 2 isoform nn

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:385 → 445
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    44. NM_001375707.1 → NP_001362636.1  abl interactor 2 isoform oo

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:384 → 444
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    45. NM_001375708.1 → NP_001362637.1  abl interactor 2 isoform pp

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:385 → 419
      SH3; Src Homology 3 domain superfamily

    46. NM_001375709.1 → NP_001362638.1  abl interactor 2 isoform qq

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:384 → 418
      SH3; Src Homology 3 domain superfamily

    47. NM_001375710.1 → NP_001362639.1  abl interactor 2 isoform rr

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:383 → 443
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 163
      Abi_HHR; Abl-interactor HHR

    48. NM_001375711.1 → NP_001362640.1  abl interactor 2 isoform ss

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:378 → 438
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:196 → 323
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    49. NM_001375712.1 → NP_001362641.1  abl interactor 2 isoform tt

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EP65
      Conserved Domains (3) summary
      PHA03247
      Location:221 → 348
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:403 → 438
      SH3; Src Homology 3 domain superfamily

    50. NM_001375714.1 → NP_001362643.1  abl interactor 2 isoform uu

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:376 → 436
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:165 → 301
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    51. NM_001375717.1 → NP_001362646.1  abl interactor 2 isoform vv

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:374 → 434
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:48 → 124
      Abi_HHR; Abl-interactor HHR

    52. NM_001375719.1 → NP_001362648.1  abl interactor 2 isoform ww

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/Swiss-Prot
      B4DSN1, Q13147, Q13249, Q13801, Q9BV70, Q9NYB9
      Conserved Domains (3) summary
      cd11972
      Location:373 → 433
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:191 → 318
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:63 → 139
      Abi_HHR; Abl-interactor HHR

    53. NM_001375721.1 → NP_001362650.1  abl interactor 2 isoform xx

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:369 → 429
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:48 → 118
      Abi_HHR; Abl-interactor HHR

    54. NM_001375722.1 → NP_001362651.1  abl interactor 2 isoform yy

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:368 → 428
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:48 → 118
      Abi_HHR; Abl-interactor HHR

    55. NM_001375723.1 → NP_001362652.1  abl interactor 2 isoform zz

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:365 → 425
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    56. NM_001375724.1 → NP_001362653.1  abl interactor 2 isoform aaa

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:364 → 424
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    57. NM_001375725.1 → NP_001362654.1  abl interactor 2 isoform bbb

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:363 → 423
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    58. NM_001375726.1 → NP_001362655.1  abl interactor 2 isoform ccc

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:362 → 422
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    59. NM_001375727.1 → NP_001362656.1  abl interactor 2 isoform ddd

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:358 → 418
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:147 → 283
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 95
      Abi_HHR; Abl-interactor HHR

    60. NM_001375728.1 → NP_001362657.1  abl interactor 2 isoform eee

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:358 → 418
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    61. NM_001375729.1 → NP_001362658.1  abl interactor 2 isoform fff

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:357 → 417
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:146 → 282
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 95
      Abi_HHR; Abl-interactor HHR

    62. NM_001375730.1 → NP_001362659.1  abl interactor 2 isoform ggg

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:357 → 417
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    63. NM_001375731.1 → NP_001362660.1  abl interactor 2 isoform hhh

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:356 → 416
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    64. NM_001375732.1 → NP_001362661.1  abl interactor 2 isoform iii

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:347 → 407
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:165 → 292
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    65. NM_001375733.1 → NP_001362662.1  abl interactor 2 isoform jjj

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:341 → 401
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:159 → 286
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    66. NM_001375734.1 → NP_001362663.1  abl interactor 2 isoform kkk

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      Q53SH3
      Conserved Domains (2) summary
      cd11972
      Location:340 → 400
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    67. NM_001375735.1 → NP_001362664.1  abl interactor 2 isoform lll

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:338 → 398
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 89
      Abi_HHR; Abl-interactor HHR

    68. NM_001375736.1 → NP_001362665.1  abl interactor 2 isoform mmm

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:338 → 398
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:156 → 283
      PHA03247; large tegument protein UL36; Provisional

    69. NM_001375737.1 → NP_001362666.1  abl interactor 2 isoform nnn

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 163
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:364 → 399
      SH3; Src Homology 3 domain superfamily

    70. NM_001375738.1 → NP_001362667.1  abl interactor 2 isoform ooo

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:336 → 396
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    71. NM_001375739.1 → NP_001362668.1  abl interactor 2 isoform ppp

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:335 → 395
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    72. NM_001375740.1 → NP_001362669.1  abl interactor 2 isoform rrr

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:334 → 394
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 163
      Abi_HHR; Abl-interactor HHR

    73. NM_001375741.1 → NP_001362670.1  abl interactor 2 isoform sss

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:329 → 389
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    74. NM_001375742.1 → NP_001362671.1  abl interactor 2 isoform ttt

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:328 → 388
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:146 → 273
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    75. NM_001375743.1 → NP_001362672.1  abl interactor 2 isoform uuu

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:329 → 363
      SH3; Src Homology 3 domain superfamily

    76. NM_001375744.1 → NP_001362673.1  abl interactor 2 isoform vvv

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (1) summary
      cd11972
      Location:326 → 386
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2

    77. NM_001375745.1 → NP_001362674.1  abl interactor 2 isoform www

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:326 → 386
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:146 → 273
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 95
      Abi_HHR; Abl-interactor HHR

    78. NM_001375746.1 → NP_001362675.1  abl interactor 2 isoform xxx

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (1) summary
      cd11972
      Location:325 → 385
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2

    79. NM_001375747.1 → NP_001362676.1  abl interactor 2 isoform yyy

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:319 → 379
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:168 → 253
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:48 → 118
      Abi_HHR; Abl-interactor HHR

    80. NM_001375748.1 → NP_001362677.1  abl interactor 2 isoform zzz

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:309 → 369
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 89
      Abi_HHR; Abl-interactor HHR

    81. NM_001375749.1 → NP_001362678.1  abl interactor 2 isoform aaaa

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (1) summary
      cd11972
      Location:306 → 366
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2

    82. NM_001375750.1 → NP_001362679.1  abl interactor 2 isoform bbbb

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (3) summary
      cd11972
      Location:303 → 363
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:147 → 274
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:19 → 95
      Abi_HHR; Abl-interactor HHR

    83. NM_001375751.1 → NP_001362680.1  abl interactor 2 isoform cccc

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:290 → 350
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:19 → 82
      Abi_HHR; Abl-interactor HHR

    84. NM_001375752.1 → NP_001362681.1  abl interactor 2 isoform dddd

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:280 → 340
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:39 → 100
      Abi_HHR; Abl-interactor HHR

    85. NM_001375753.1 → NP_001362682.1  abl interactor 2 isoform eeee

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      pfam07815
      Location:19 → 89
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:262 → 296
      SH3; Src Homology 3 domain superfamily

    86. NM_001375754.1 → NP_001362683.1  abl interactor 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      cd11972
      Location:340 → 400
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:48 → 118
      Abi_HHR; Abl-interactor HHR

    87. NM_001375755.1 → NP_001362684.1  abl interactor 2 isoform qqq

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Conserved Domains (2) summary
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:336 → 370
      SH3; Src Homology 3 domain superfamily

    88. NM_005759.7 → NP_005750.4  abl interactor 2 isoform c

      See identical proteins and their annotated locations for NP_005750.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in both the 5' and central coding regions, but includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC018891, AC080075
      Consensus CDS
      CCDS2358.1
      UniProtKB/TrEMBL
      E7EW77
      Related
      ENSP00000261017.5, ENST00000261017.9
      Conserved Domains (2) summary
      cd11972
      Location:414 → 474
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    RNA

    1. NR_164704.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    2. NR_164705.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    3. NR_164706.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    4. NR_164707.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    5. NR_164708.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    6. NR_164709.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    7. NR_164710.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    8. NR_164711.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    9. NR_164712.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    10. NR_164713.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075
      Related
      ENST00000261016.11

    11. NR_164714.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    12. NR_164715.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    13. NR_164716.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    14. NR_164717.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    15. NR_164718.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC018891, AC080075

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      203328394..203432169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442823.1 → XP_047298779.1  abl interactor 2 isoform X1

    2. XM_047442826.1 → XP_047298782.1  abl interactor 2 isoform X4

    3. XM_006712180.4 → XP_006712243.1  abl interactor 2 isoform X9

      See identical proteins and their annotated locations for XP_006712243.1

      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:420 → 480
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    4. XM_047442831.1 → XP_047298787.1  abl interactor 2 isoform X10

    5. XM_006712181.4 → XP_006712244.1  abl interactor 2 isoform X12

      See identical proteins and their annotated locations for XP_006712244.1

      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:391 → 451
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    6. XM_017003132.3 → XP_016858621.1  abl interactor 2 isoform X14

      UniProtKB/TrEMBL
      E7EW77

    7. XM_047442832.1 → XP_047298788.1  abl interactor 2 isoform X11

    8. XM_006712182.4 → XP_006712245.1  abl interactor 2 isoform X13

      See identical proteins and their annotated locations for XP_006712245.1

      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:390 → 450
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    9. XM_047442834.1 → XP_047298790.1  abl interactor 2 isoform X15

    10. XM_047442835.1 → XP_047298791.1  abl interactor 2 isoform X16

    11. XM_017003144.3 → XP_016858633.1  abl interactor 2 isoform X19

      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (2) summary
      cd11972
      Location:342 → 402
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      pfam07815
      Location:93 → 169
      Abi_HHR; Abl-interactor HHR

    12. XM_017003138.3 → XP_016858627.1  abl interactor 2 isoform X17

      UniProtKB/TrEMBL
      E7EW77
      Conserved Domains (3) summary
      cd11972
      Location:370 → 430
      SH3_Abi2; Src homology 3 domain of Abl Interactor 2
      PHA03247
      Location:219 → 304
      PHA03247; large tegument protein UL36; Provisional
      pfam07815
      Location:93 → 156
      Abi_HHR; Abl-interactor HHR

    13. XM_047442824.1 → XP_047298780.1  abl interactor 2 isoform X2

    14. XM_047442827.1 → XP_047298783.1  abl interactor 2 isoform X5

    15. XM_047442825.1 → XP_047298781.1  abl interactor 2 isoform X3

    16. XM_047442828.1 → XP_047298784.1  abl interactor 2 isoform X6

    17. XM_047442829.1 → XP_047298785.1  abl interactor 2 isoform X7

    18. XM_047442836.1 → XP_047298792.1  abl interactor 2 isoform X18

    19. XM_047442837.1 → XP_047298793.1  abl interactor 2 isoform X20

    20. XM_047442830.1 → XP_047298786.1  abl interactor 2 isoform X8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      203810332..203914077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340092.1 → XP_054196067.1  abl interactor 2 isoform X1

    2. XM_054340100.1 → XP_054196075.1  abl interactor 2 isoform X9

    3. XM_054340101.1 → XP_054196076.1  abl interactor 2 isoform X10

    4. XM_054340103.1 → XP_054196078.1  abl interactor 2 isoform X12

    5. XM_054340105.1 → XP_054196080.1  abl interactor 2 isoform X14

    6. XM_054340102.1 → XP_054196077.1  abl interactor 2 isoform X11

    7. XM_054340104.1 → XP_054196079.1  abl interactor 2 isoform X13

    8. XM_054340106.1 → XP_054196081.1  abl interactor 2 isoform X15

    9. XM_054340107.1 → XP_054196082.1  abl interactor 2 isoform X16

    10. XM_054340110.1 → XP_054196085.1  abl interactor 2 isoform X19

    11. XM_054340108.1 → XP_054196083.1  abl interactor 2 isoform X17

    12. XM_054340093.1 → XP_054196068.1  abl interactor 2 isoform X2

    13. XM_054340095.1 → XP_054196070.1  abl interactor 2 isoform X21

    14. XM_054340096.1 → XP_054196071.1  abl interactor 2 isoform X22

    15. XM_054340097.1 → XP_054196072.1  abl interactor 2 isoform X5

    16. XM_054340094.1 → XP_054196069.1  abl interactor 2 isoform X3

    17. XM_054340098.1 → XP_054196073.1  abl interactor 2 isoform X6

    18. XM_054340099.1 → XP_054196074.1  abl interactor 2 isoform X7

    19. XM_054340109.1 → XP_054196084.1  abl interactor 2 isoform X18

    20. XM_054340111.1 → XP_054196086.1  abl interactor 2 isoform X20

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYB9.1 GenPept UniProtKB/Swiss-Prot:Q9NYB9

    Gene LinkOut

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