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    CG17234 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59225, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CG17234provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042187
    Locus tag
    Dmel_CG17234
    See related
    AllianceGenome:FB:FBgn0042187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG17234; SP113
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Is expressed in seminal receptacle and spermatheca. Orthologous to human PRSS36 (serine protease 36) and PRSS53 (serine protease 53). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CG17234 in Genome Data Viewer
    Location:
    22D5-22D5; 2-5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2253045..2253852)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2253045..2253852)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Serine protease 12 Neighboring gene uncharacterized protein Neighboring gene Spermathecal endopeptidase 1 Neighboring gene long non-coding RNA:CR44787

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionary expressed sequence tag analysis of Drosophila spermatheca genes. Prokupek A, et al. Evolution, 2008 Nov. PMID 18752616
    2. Protease gene duplication and proteolytic activity in Drosophila female reproductive tracts. Kelleher ES, et al. Mol Biol Evol, 2009 Sep. PMID 19546158, Free PMC Article
    3. Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster. Lawniczak MK, et al. Mol Biol Evol, 2007 Sep. PMID 17573377
    4. Drosophila type IV collagen mutation associates with immune system activation and intestinal dysfunction. Kiss M, et al. Matrix Biol, 2016 Jan. PMID 26363084
    5. Transcriptional profiling of the sperm storage organs of Drosophila melanogaster. Prokupek AM, et al. Insect Mol Biol, 2009 Aug. PMID 19453766

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A female reproductive tract expressed serine protease, GenBank Accession Number AM765885, that show increased transcription shortly after mating.
      Title: Molecular population genetics of female-expressed mating-induced serine proteases in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17234-PA
    NP_722785.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2253045..2253852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164470.2 → NP_722785.1  uncharacterized protein Dmel_CG17234 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722785.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMU6, Q9VQ99
      Related
      FBpp0077433
      Conserved Domains (2) summary
      smart00020
      Location:26 → 243
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:27 → 243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ99 Q9VQ99

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