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    Il18r1 interleukin 18 receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 16182, updated on 12-Nov-2024

    Summary

    Official Symbol
    Il18r1provided by MGI
    Official Full Name
    interleukin 18 receptor 1provided by MGI
    Primary source
    MGI:MGI:105383
    See related
    Ensembl:ENSMUSG00000026070 AllianceGenome:MGI:105383
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il1rrp; Il18ralpha
    Summary
    Enables interleukin-18 receptor activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within several processes, including T-helper 1 cell differentiation; interleukin-18-mediated signaling pathway; and positive regulation of type II interferon production. Predicted to be part of interleukin-18 receptor complex. Predicted to be active in cell surface and plasma membrane. Is expressed in aorta-gonad-mesonephros and thymus primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL18R1 (interleukin 18 receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 4.7), bladder adult (RPKM 0.7) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Il18r1 in Genome Data Viewer
    Location:
    1 B; 1 19.27 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (40504712..40540014)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (40465552..40500854)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_00741 Neighboring gene interleukin 18 receptor accessory protein Neighboring gene predicted gene, 35801 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-18 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-18 binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables interleukin-18 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-18 receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables interleukin-18 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-18 receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T-helper 1 cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-18-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within interleukin-18-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in interleukin-18-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interleukin-18-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within natural killer cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T-helper 1 cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of T-helper 1 cell cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type II interferon production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of type II interferon production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of interleukin-18 receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of interleukin-18 receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-18 receptor 1
    Names
    CD218 antigen-like family member A
    IL-18R-1
    IL-18R-alpha
    IL-18R1
    IL-18Ralpha
    IL-1Rrp
    IL1 receptor-related protein
    IL1R-rp
    interleukin 1 receptor related protein
    interleukin-18 receptor alpha
    NP_001155314.1
    NP_001155315.1
    NP_032391.1
    XP_006495790.1
    XP_006495791.1
    XP_006495792.1
    XP_006495793.1
    XP_006495795.1
    XP_006495797.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161842.1NP_001155314.1  interleukin-18 receptor 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001155314.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC167126
      Consensus CDS
      CCDS48247.1
      UniProtKB/TrEMBL
      Q8C257
      Related
      ENSMUSP00000128277.2, ENSMUST00000167723.8
      Conserved Domains (3) summary
      cd00096
      Location:46113
      Ig; Immunoglobulin domain
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    2. NM_001161843.1NP_001155315.1  interleukin-18 receptor 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001155315.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice pattern in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AC167126
      Consensus CDS
      CCDS48247.1
      UniProtKB/TrEMBL
      Q8C257
      Related
      ENSMUSP00000141695.2, ENSMUST00000193391.6
      Conserved Domains (3) summary
      cd00096
      Location:46113
      Ig; Immunoglobulin domain
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    3. NM_008365.2NP_032391.1  interleukin-18 receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_032391.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC167126
      Consensus CDS
      CCDS35549.1
      UniProtKB/Swiss-Prot
      Q61098
      Related
      ENSMUSP00000103679.3, ENSMUST00000108044.4
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      40504712..40540014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495727.3XP_006495790.1  interleukin-18 receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006495790.1

      UniProtKB/Swiss-Prot
      Q61098
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    2. XM_006495729.5XP_006495792.1  interleukin-18 receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006495792.1

      UniProtKB/Swiss-Prot
      Q61098
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    3. XM_006495734.5XP_006495797.1  interleukin-18 receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006495797.1

      UniProtKB/Swiss-Prot
      Q61098
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    4. XM_006495730.3XP_006495793.1  interleukin-18 receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006495793.1

      UniProtKB/Swiss-Prot
      Q61098
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    5. XM_006495732.3XP_006495795.1  interleukin-18 receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006495795.1

      UniProtKB/Swiss-Prot
      Q61098
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain
    6. XM_006495728.3XP_006495791.1  interleukin-18 receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006495791.1

      UniProtKB/Swiss-Prot
      Q61098
      Conserved Domains (4) summary
      PHA02785
      Location:157257
      PHA02785; IL-beta-binding protein; Provisional
      smart00410
      Location:26112
      IG_like; Immunoglobulin like
      pfam01582
      Location:374534
      TIR; TIR domain
      cl11960
      Location:131205
      Ig; Immunoglobulin domain