PRKCI protein kinase C iota [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: PRKCI
Gene description: protein kinase C iota
Locus tag: CR201_G0034705
See related: Ensembl:ENSPPYG00000014289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	2	NC_085928.1 (180164518..180248050)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	3	NC_071988.1 (167960722..168044567)

Chromosome 2 - NC_085928.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D10S275 (e-PCR)
- UniSTS:147992

D3S3929 (e-PCR)
- UniSTS:28210

SHGC-77518 (e-PCR)
- UniSTS:19280

SHGC-59107 (e-PCR)
- UniSTS:94299

RH65381 (e-PCR)
- UniSTS:92818

DXS7583 (e-PCR)
- UniSTS:99736

G63586 (e-PCR)
- UniSTS:140697

G62256 (e-PCR)
- UniSTS:139428

RH65164 (e-PCR)
- UniSTS:86955

SHGC-77522 (e-PCR)
- UniSTS:8132

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: protein kinase C iota type

Names: nPKC-iota

NP_001126946.1

EC 2.7.11.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001133474.1 → NP_001126946.1 protein kinase C iota type

See identical proteins and their annotated locations for NP_001126946.1

Status: PROVISIONAL

Source sequence(s)

CR861237

UniProtKB/TrEMBL

A0A8I5TAH4

Related

ENSPPYP00000015972.3, ENSPPYT00000016611.3

Conserved Domains (4) summary

cd06404
Location:17 → 99

PB1_aPKC; PB1 domain is an essential modular domain of the atypical protein kinase C (aPKC) which in complex with Par6 and Par3 proteins is crucial for establishment of apical-basal polarity of animal cells. PB1 domain is a modular domain mediating specific ...

smart00220
Location:245 → 513

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05618
Location:224 → 587

STKc_aPKC_iota; Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota

pfam00130
Location:132 → 184

C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)