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    speck speck [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37867, updated on 18-Sep-2024

    Summary

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    Official Symbol
    speckprovided by FlyBase
    Official Full Name
    speckprovided by FlyBase
    Primary source
    FLYBASE:FBgn0287831
    Locus tag
    Dmel_CG3318
    See related
    AllianceGenome:FB:FBgn0287831
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AA-NAT1; aaNat; aaNAT; AANAT; aaNAT-1; aaNAT1; Aanat1; AANAT1; aaNAT1a; aaNAT1b; AANATA; AANATB; CG3318; Dat; DAT; Dat1; DAT1; DmAANATA; DmAANATB; Dmel\CG3318; NAT1; sp
    Summary
    Enables aralkylamine N-acetyltransferase activity and arylamine N-acetyltransferase activity. Involved in catecholamine metabolic process. Located in cytoplasm. Is expressed in several structures, including epithelium; gut section; nervous system; presumptive embryonic/larval nervous system; and yolk nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See speck in Genome Data Viewer
    Location:
    60B12-60C1; 2-106 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24139563..24157762)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20027086..20045285)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44826 Neighboring gene Zinc finger protein RP-8 Neighboring gene N(alpha)-acetyltransferase 35 Neighboring gene DnaJ-like-60 Neighboring gene uncharacterized protein Neighboring gene spaghetti Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AANAT1 functions in astrocytes to regulate sleep homeostasis. Davla S, et al. Elife, 2020 Sep 21. PMID 32955431, Free PMC Article
    2. speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene. Spana EP, et al. G3 (Bethesda), 2020 Sep 2. PMID 32709620, Free PMC Article
    3. Various Wolbachia genotypes differently influence host Drosophila dopamine metabolism and survival under heat stress conditions. Gruntenko NЕ, et al. BMC Evol Biol, 2017 Dec 28. PMID 29297293, Free PMC Article
    4. A single gene causes an interspecific difference in pigmentation in Drosophila. Ahmed-Braimah YH, et al. Genetics, 2015 May. PMID 25769982, Free PMC Article
    5. Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism. Cheng KC, et al. Biochem J, 2012 Sep 15. PMID 22716280, Free PMC Article

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene.
      Title: speck, First Identified in Drosophila melanogaster in 1910, Is Encoded by the Arylalkalamine N-Acetyltransferase (AANAT1) Gene.
    2. AANAT1 functions in astrocytes to regulate sleep homeostasis.
      Title: AANAT1 functions in astrocytes to regulate sleep homeostasis.
    3. Data suggest Glu47 acts as general base with apparent pKa of 7.0 in biocatalysis by AANAT; 2 equally active variants exist, with AANATA differing from AANATB by truncation of 35 amino acids from N-terminus. [AANAT; arylalkylamine Nacetyltransferase]
      Title: Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases.
    4. Here we report a Drosophila dopamine-related locomotor endophenotype that is shared by pan-neuronal knockdown of orthologs of the ADHD-associated genes Dopamine transporter (DAT1) and Latrophilin (LPHN3), and of a gene causing a monogenic disorder with frequent ADHD comorbidity.
      Title: ADHD-associated dopamine transporter, latrophilin and neurofibromin share a dopamine-related locomotor signature in Drosophila.
    5. Dat is entirely responsible for a pigmentation difference between Drosophila species.
      Title: A single gene causes an interspecific difference in pigmentation in Drosophila.
    6. Dat possesses a specialized active site structure dedicated to a catalytic mechanism.
      Title: Crystal structure of the dopamine N-acetyltransferase-acetyl-CoA complex provides insights into the catalytic mechanism.
    7. Dopamine-dependent arylalkylamine N-acetyltransferase plays a role in the regulation of dopamine content carried out by gonadotropins.
      Title: Role of arylalkylamine N-acetyltransferase in regulation of biogenic amines levels by gonadotropins in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aralkylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables arylamine N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in catecholamine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chitin-based cuticle sclerotization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dopamine catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in octopamine catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of circadian sleep/wake cycle, sleep TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in serotonin catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in sleep TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    speck
    Names
    CG3318-PA
    CG3318-PB
    CG3318-PC
    arylalkylamine N-acetyltransferase
    arylalkylamine N-acetyltransferase 1
    arylalkylamine N-acetyltransferase-1
    dopamine N acetyltransferase
    dopamine N-acetyltransferase
    dopamine acetyltransferase
    speck-PA
    speck-PB
    speck-PC
    NP_001401022.1
    NP_523839.2
    NP_995934.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24139563..24157762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001414080.1 → NP_001401022.1  speck, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MKK2, Q94521, Q9TWF1

    2. NM_079115.3 → NP_523839.2  speck, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523839.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94521
      Related
      FBpp0072163
      Conserved Domains (2) summary
      COG0456
      Location:133 → 200
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:129 → 196
      Acetyltransf_1; Acetyltransferase (GNAT) family

    3. NM_206212.2 → NP_995934.1  speck, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995934.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MKK2, Q94521, Q9TWF1
      Conserved Domains (2) summary
      COG0456
      Location:168 → 235
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      cl17182
      Location:183 → 227
      NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94521.1 Q94521

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