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    Lrr1 leucine rich repeat protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 69706, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrr1provided by MGI
    Official Full Name
    leucine rich repeat protein 1provided by MGI
    Primary source
    MGI:MGI:1916956
    See related
    Ensembl:ENSMUSG00000034883 AllianceGenome:MGI:1916956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LRR-1; Ppil5; 2410005L11Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Predicted to be located in nucleus. Orthologous to human LRR1 (leucine rich repeat protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E14 (RPKM 5.9), liver E14.5 (RPKM 4.9) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrr1 in Genome Data Viewer
    Location:
    12 C2; 12 28.73 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (69215588..69225786)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (69168814..69179012)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:70260497-70260606 Neighboring gene ribosomal protein S29 Neighboring gene 7S RNA 1 Neighboring gene STARR-seq mESC enhancer starr_32359 Neighboring gene STARR-positive B cell enhancer ABC_E8485 Neighboring gene STARR-positive B cell enhancer ABC_E5332 Neighboring gene ribosomal protein L36A-like Neighboring gene mannoside acetylglucosaminyltransferase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat protein 1
    Names
    peptidylprolyl isomerase (cyclophilin) like 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081406.2 → NP_001074875.1  leucine-rich repeat protein 1

      See identical proteins and their annotated locations for NP_001074875.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AC099934
      Consensus CDS
      CCDS36462.1
      UniProtKB/Swiss-Prot
      D3YY91
      Related
      ENSMUSP00000106251.2, ENSMUST00000110621.3
      Conserved Domains (3) summary
      cd00116
      Location:184 → 269
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:164 → 186
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:185 → 246
      LRR_8; Leucine rich repeat

    RNA

    1. NR_155206.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large part of the coding region found in variant 1.
      Source sequence(s)
      AC099934, AK010419, BG067404
      Related
      ENSMUST00000222520.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      69215588..69225786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YY91.1 GenPept UniProtKB/Swiss-Prot:D3YY91

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