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    Renbp renin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 19703, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Renbpprovided by MGI
    Official Full Name
    renin binding proteinprovided by MGI
    Primary source
    MGI:MGI:105940
    See related
    Ensembl:ENSMUSG00000031387 AllianceGenome:MGI:105940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Age; Rnbp
    Summary
    Enables N-acylglucosamine 2-epimerase activity. Acts upstream of or within N-acetylglucosamine metabolic process. Orthologous to human RENBP (renin binding protein). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in placenta adult (RPKM 61.2), kidney adult (RPKM 37.8) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Renbp in Genome Data Viewer
    Location:
    X A7.3; X 37.49 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72965727..72974408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73922121..73930850, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 4 Neighboring gene arginine vasopressin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71157031-71157252 Neighboring gene STARR-seq mESC enhancer starr_47360 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_47361 Neighboring gene host cell factor C1 Neighboring gene STARR-seq mESC enhancer starr_47362 Neighboring gene STARR-seq mESC enhancer starr_47363 Neighboring gene STARR-seq mESC enhancer starr_47364 Neighboring gene predicted gene 8545

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor. Schmitz C, et al. J Biol Chem, 2000 May 19. PMID 10809771
    2. The chromosome localization and the HCF repeats of the human host cell factor gene (HCFC1) are conserved in the mouse homologue. Frattini A, et al. Genomics, 1996 Mar 1. PMID 8833156
    3. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
    4. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acylglucosamine 2-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylglucosamine 2-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acylglucosamine 2-epimerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables N-acylglucosamine 2-epimerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables purine nucleotide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acetylglucosamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in N-acetylglucosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylmannosamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-acetylmannosamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acetylneuraminate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in N-acetylneuraminate catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acylglucosamine 2-epimerase
    Names
    GlcNAc 2-epimerase
    N-acetyl-D-glucosamine 2-epimerase
    NP_001158176.1
    NP_001412884.1
    NP_001412885.1
    NP_001412886.1
    NP_001412887.1
    NP_001412888.1
    NP_075621.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164704.2 → NP_001158176.1  N-acylglucosamine 2-epimerase isoform 2

      See identical proteins and their annotated locations for NP_001158176.1

      Status: VALIDATED

      Description
      Transcript Variant:
      Source sequence(s)
      AL672002
      Consensus CDS
      CCDS57763.1
      UniProtKB/TrEMBL
      A0A8Z1S8W2
      Related
      ENSMUSP00000110020.2, ENSMUST00000114379.8
      Conserved Domains (1) summary
      cd00249
      Location:15 → 394
      AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

    2. NM_001425955.1 → NP_001412884.1  N-acylglucosamine 2-epimerase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), encodes the longest isoform (3).
      Source sequence(s)
      AL672002
      UniProtKB/Swiss-Prot
      P82343, Q3TIZ6, Q3UJ23, Q80Z67, Q91WI9, Q9CXI1
      UniProtKB/TrEMBL
      D6RHA2
      Related
      ENSMUSP00000116549.2, ENSMUST00000155597.2

    3. NM_001425956.1 → NP_001412885.1  N-acylglucosamine 2-epimerase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672002

    4. NM_001425957.1 → NP_001412886.1  N-acylglucosamine 2-epimerase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672002

    5. NM_001425958.1 → NP_001412887.1  N-acylglucosamine 2-epimerase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL672002

    6. NM_001425959.1 → NP_001412888.1  N-acylglucosamine 2-epimerase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL672002

    7. NM_023132.4 → NP_075621.3  N-acylglucosamine 2-epimerase isoform 1

      See identical proteins and their annotated locations for NP_075621.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AL672002
      Consensus CDS
      CCDS41015.2
      UniProtKB/TrEMBL
      A0A8Z1SL50
      Related
      ENSMUSP00000112277.2, ENSMUST00000116578.8
      Conserved Domains (1) summary
      cd00249
      Location:15 → 408
      AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

    RNA

    1. NR_189639.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672002

    2. NR_189640.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672002

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72965727..72974408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P82343.4 GenPept UniProtKB/Swiss-Prot:P82343

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