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    Sh2d3c SH2 domain containing 3C [ Mus musculus (house mouse) ]

    Gene ID: 27387, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sh2d3cprovided by MGI
    Official Full Name
    SH2 domain containing 3Cprovided by MGI
    Primary source
    MGI:MGI:1351631
    See related
    Ensembl:ENSMUSG00000059013 AllianceGenome:MGI:1351631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chat; Nsp3; Shep1
    Summary
    Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and small GTPase-mediated signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in cytosol. Orthologous to human SH2D3C (SH2 domain containing 3C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lung adult (RPKM 40.4), spleen adult (RPKM 34.7) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh2d3c in Genome Data Viewer
    Location:
    2 B; 2 22.09 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (32611072..32645008)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (32721037..32755007)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8785 Neighboring gene cyclin dependent kinase 9 Neighboring gene STARR-positive B cell enhancer ABC_E7807 Neighboring gene microRNA 3960 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:32577778-32577887 Neighboring gene predicted gene, 33457 Neighboring gene STARR-positive B cell enhancer ABC_E3368 Neighboring gene RIKEN cDNA 6330409D20 gene Neighboring gene STARR-positive B cell enhancer ABC_E411 Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene torsin family 2, member A Neighboring gene STARR-positive B cell enhancer ABC_E10097 Neighboring gene cilia and flagella associated protein 157 Neighboring gene peptidyl-tRNA hydrolase 1 homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The adaptor protein Sh2d3c is critical for marginal zone B cell development and function. Al-Shami A, et al. J Immunol, 2010 Jul 1. PMID 20505138
    2. The hematopoietic isoform of Cas-Hef1-associated signal transducer regulates chemokine-induced inside-out signaling and T cell trafficking. Regelmann AG, et al. Immunity, 2006 Dec. PMID 17174122
    3. A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. Dodelet VC, et al. J Biol Chem, 1999 Nov 5. PMID 10542222
    4. SHEP1 partners with CasL to promote marginal zone B-cell maturation. Browne CD, et al. Proc Natl Acad Sci U S A, 2010 Nov 2. PMID 20956287, Free PMC Article
    5. Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1. Herbin O, et al. Arterioscler Thromb Vasc Biol, 2016 Sep. PMID 27417580, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chat-H regulates atherosclerosis development by controlling monocyte adhesion and recruitment to the plaques.
      Title: Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
    2. Shep1 plays a critical role in the in vivo regulation of Src activity and Cas downstream signaling through Crk protein.
      Title: The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.
    3. SHEP1 and CasL are constitutively associated in B cells.
      Title: SHEP1 partners with CasL to promote marginal zone B-cell maturation.
    4. Shep1 plays an important role in the early ingrowth of peripheral olfactory sensory axons into the forebrain.
      Title: The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.
    5. Sh2d3c is required for proper localization of cells, particularly marginal zone B cells in vivo; thymi of Sh2d3c-deficient mice show no maturational abnormalities.
      Title: The adaptor protein Sh2d3c is critical for marginal zone B cell development and function.
    6. glutamic acid mutation of tyrosine 635 makes SHEP1 unable to promote Cas-Crk association, membrane ruffling, and cell migration toward epidermal growth factor (EGF), implying that these activities of SHEP1 depend upon a physical interaction with Cas
      Title: SHEP1 function in cell migration is impaired by a single amino acid mutation that disrupts association with the scaffolding protein cas but not with Ras GTPases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130521

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing protein 3C
    Names
    Cas/HEF1-associated signal transducer
    SH2 domain-containing Eph receptor-binding protein 1
    novel SH2-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252547.2 → NP_001239476.1  SH2 domain-containing protein 3C isoform 2

      See identical proteins and their annotated locations for NP_001239476.1

      Status: VALIDATED

      Source sequence(s)
      AL772271
      Consensus CDS
      CCDS57168.1
      UniProtKB/Swiss-Prot
      Q9QZS8
      Related
      ENSMUSP00000108868.3, ENSMUST00000113242.5
      Conserved Domains (2) summary
      cd10337
      Location:56 → 190
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:427 → 604
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. NM_001412517.1 → NP_001399446.1  SH2 domain-containing protein 3C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772271

    3. NM_001412518.1 → NP_001399447.1  SH2 domain-containing protein 3C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772271

    4. NM_001412519.1 → NP_001399448.1  SH2 domain-containing protein 3C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772271

    5. NM_001412520.1 → NP_001399449.1  SH2 domain-containing protein 3C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772271

    6. NM_001412521.1 → NP_001399450.1  SH2 domain-containing protein 3C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL772271

    7. NM_001412522.1 → NP_001399451.1  SH2 domain-containing protein 3C isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL772271

    8. NM_001412523.1 → NP_001399452.1  SH2 domain-containing protein 3C isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL772271

    9. NM_013781.4 → NP_038809.1  SH2 domain-containing protein 3C isoform 1

      See identical proteins and their annotated locations for NP_038809.1

      Status: VALIDATED

      Source sequence(s)
      AL772271
      Consensus CDS
      CCDS15928.1
      UniProtKB/Swiss-Prot
      A2AK84, Q9JME1, Q9QZS8
      Related
      ENSMUSP00000073866.5, ENSMUST00000074248.11
      Conserved Domains (2) summary
      cd10337
      Location:208 → 342
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:579 → 756
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      32611072..32645008
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498095.4 → XP_006498158.1  SH2 domain-containing protein 3C isoform X1

      Conserved Domains (2) summary
      cd10337
      Location:208 → 342
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:565 → 742
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    2. XM_006498096.2 → XP_006498159.1  SH2 domain-containing protein 3C isoform X5

      Conserved Domains (1) summary
      cl02485
      Location:230 → 407
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...

    3. XM_036162272.1 → XP_036018165.1  SH2 domain-containing protein 3C isoform X4

      Conserved Domains (2) summary
      cd10337
      Location:55 → 189
      SH2_BCAR3; Src homology 2 (SH2) domain in the Breast Cancer Anti-estrogen Resistance protein 3
      cl02485
      Location:412 → 589
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QZS8.1 GenPept UniProtKB/Swiss-Prot:Q9QZS8

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