Imp IGF-II mRNA-binding protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Impprovided by FlyBase
Official Full Name: IGF-II mRNA-binding proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0285926
Locus tag: Dmel_CG1691
See related: AllianceGenome:FB:FBgn0285926
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:fe2B3; anon-WO0140519.39; cg1691; CG1691; dIMP; Dmel\CG1691; FGC026A04; IGF-II; IGF2BP1; imp; IMP; IMP-1; l(1)G0072; mre11; MRE11; ORE-9
Summary: Enables mRNA 3'-UTR binding activity. Involved in several processes, including germ-line stem-cell niche homeostasis; nervous system development; and positive regulation of receptor signaling pathway via JAK-STAT. Located in axon; cytosol; and neuronal cell body. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult brain cell body rind; epithelial cell; epithelium; germline cell; and neuroblasts. Used to study acquired metabolic disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IGF2BP1 (insulin like growth factor 2 mRNA binding protein 1); IGF2BP2 (insulin like growth factor 2 mRNA binding protein 2); and IGF2BP3 (insulin like growth factor 2 mRNA binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 9F1-9F4; 1-33 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (10787869..10824277, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (10681902..10718310, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.
Title: The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila.
Imp is expressed in INPs and newborn neurons where it regulates neuropil targeting in the central complex.
Title: Imp is expressed in INPs and newborn neurons where it regulates neuropil targeting in the central complex.
Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability.
Title: Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability.
IMP regulates Notch signalling by controlling the localisation of Kuzbanian to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway.
Title: IMP regulates Kuzbanian to control the timing of Notch signalling in Drosophila follicle cells.
Study shows that the prion-like domain (PLD) of Drosophila Imp is essential for the developmentally-controlled localization of Imp ribonucleoprotein (RNP) granules to axons and regulates in vivo axonal remodeling. Imp PLD restricts granule assembly, revealing a novel function for PLDs in RNP granule homeostasis. Study uncovers a physiological function for PLDs in the spatio-temporal control of neuronal RNP assemblies.
Title: The prion-like domain of Drosophila Imp promotes axonal transport of RNP granules in vivo.
the levels of Imp and Syp RNA-binding proteins regulate neuroblasts decommissioning.
Title: Imp and Syp RNA-binding proteins govern decommissioning of Drosophila neural stem cells.
the opposing Imp/Syp gradients encode stem cell age, specifying multiple cell fates within a lineage.
Title: Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates.
The RNA binding protein Imp is a key regulator of axonal remodeling.
Title: Imp promotes axonal remodeling by regulating profilin mRNA during brain development.
IGF-II messenger RNA binding protein (Imp) counteracts endogenous small interfering RNAs to stabilize upd RNA; but similar to upd, Imp expression decreases in the hub cells of older males, which is due to the targeting of Imp by the heterochronic microRNA let-7; in the absence of Imp, upd mRNA therefore becomes unprotected and susceptible to degradation
Title: The let-7-Imp axis regulates ageing of the Drosophila testis stem-cell niche.
a role for Imp in the male germline during both spermatid elongation and premeiotic spermatogenesis.
Title: Imp (IGF-II mRNA-binding protein) is expressed during spermatogenesis in Drosophila melanogaster.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ-line stem-cell niche homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
part_of catalytic step 2 spliceosome	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of precatalytic spliceosome	HDA more info	PubMed

General protein information

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Preferred Names: IGF-II mRNA-binding protein

Names: CG1691-PA; CG1691-PB; CG1691-PC; CG1691-PD; CG1691-PE; CG1691-PF; CG1691-PG; CG1691-PH; CG1691-PJ; CG1691-PK; CG1691-PL; CG1691-PM; IGF-II messenger RNA binding protein; IGF2BP; Imp-PA; Imp-PB; Imp-PC; Imp-PD; Imp-PE; Imp-PF; Imp-PG; Imp-PH; Imp-PJ; Imp-PK; Imp-PL; Imp-PM; Insulin-like growth factor 2 mRNA binding protein 1; KH-domain protein; anon-fast-evolving-2B3; insulin-like growth factor II; mRNA-like ncRNA in embryogenesis 11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

10787869..10824277 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_167253.3 → NP_727455.1 IGF-II mRNA-binding protein, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727455.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGK4, Q8IR99

Related

FBpp0073270

Conserved Domains (1) summary

cd00105
Location:167 → 231

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_167249.3 → NP_727451.1 IGF-II mRNA-binding protein, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727451.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGK4, Q8IR99

Related

FBpp0073272

Conserved Domains (1) summary

cd00105
Location:167 → 231

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_167255.3 → NP_727457.1 IGF-II mRNA-binding protein, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727457.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NGS9, Q9VZ69

Related

FBpp0073274

Conserved Domains (1) summary

cd00105
Location:160 → 224

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_167252.3 → NP_727454.1 IGF-II mRNA-binding protein, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727454.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGK4, Q8IR99

Related

FBpp0073271

Conserved Domains (1) summary

cd00105
Location:167 → 231

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_167251.3 → NP_727453.1 IGF-II mRNA-binding protein, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727453.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGK4, Q8IR99

Related

FBpp0073269

Conserved Domains (1) summary

cd00105
Location:167 → 231

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001298162.1 → NP_001285091.1 IGF-II mRNA-binding protein, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001285091.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF14

Conserved Domains (3) summary

COG0724
Location:37 → 146

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00105
Location:232 → 296

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12359
Location:42 → 118

RRM2_VICKZ; RNA recognition motif 2 in the VICKZ family proteins
NM_001169246.2 → NP_001162717.1 IGF-II mRNA-binding protein, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162717.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JJM0, Q8IGK4

Conserved Domains (1) summary

cd00105
Location:174 → 238

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001258687.3 → NP_001245616.1 IGF-II mRNA-binding protein, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245616.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NF14

Conserved Domains (3) summary

COG0724
Location:37 → 146

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00105
Location:232 → 296

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12359
Location:42 → 118

RRM2_VICKZ; RNA recognition motif 2 in the VICKZ family proteins
NM_167250.3 → NP_727452.1 IGF-II mRNA-binding protein, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727452.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGK4, Q8IR99

Related

FBpp0073273

Conserved Domains (1) summary

cd00105
Location:167 → 231

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_001042803.3 → NP_001036268.2 IGF-II mRNA-binding protein, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036268.2

Status: REVIEWED

UniProtKB/TrEMBL

Q0KHU2

Conserved Domains (3) summary

COG0724
Location:31 → 139

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd00105
Location:225 → 289

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd12359
Location:35 → 111

RRM2_VICKZ; RNA recognition motif 2 in the VICKZ family proteins
NM_078556.4 → NP_511111.1 IGF-II mRNA-binding protein, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_511111.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NGS9, Q9VZ69

Related

FBpp0073276

Conserved Domains (1) summary

cd00105
Location:160 → 224

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
NM_167254.4 → NP_727456.1 IGF-II mRNA-binding protein, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_727456.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NGS9, Q9VZ69

Related

FBpp0073275

Conserved Domains (1) summary

cd00105
Location:160 → 224

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...