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    TJP2 tight junction protein 2 [ Canis lupus dingo (dingo) ]

    Gene ID: 112644752, updated on 10-Oct-2024

    Summary

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    Gene symbol
    TJP2
    Gene description
    tight junction protein 2
    See related
    Ensembl:ENSCAFG00020026597
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus dingo (sub-species: dingo)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See TJP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    102 current ASM325472v2 (GCF_003254725.2) 1 NC_064243.1 (88258439..88382473, complement)
    101 previous assembly UNSW_AlpineDingo_1.0 (GCF_012295265.1) 1 Unlocalized Scaffold NW_023365038.1 (88763915..88888768, complement)

    Chromosome 1 - NC_064243.1Genomic Context describing neighboring genes Neighboring gene U4 spliceosomal RNA Neighboring gene DPH3 homolog Neighboring gene uncharacterized LOC112644756 Neighboring gene uncharacterized LOC112644754 Neighboring gene 60S ribosomal protein L7a-like Neighboring gene uncharacterized LOC125752256 Neighboring gene frataxin Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene uncharacterized LOC112644762

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell junction organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of blood-brain barrier permeability IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein localization to cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tight junction protein ZO-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus dingo Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM325472v2

    Genomic

    1. NC_064243.1 Reference ASM325472v2

      Range
      88258439..88382473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025423369.3 → XP_025279154.1  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NNL3
      Conserved Domains (5) summary
      cd12027
      Location:584 → 646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:680 → 859
      GuKc; Guanylate kinase homologues
      smart00228
      Location:284 → 365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:125 → 266
      RSRP; Arginine/Serine-Rich protein 1

    2. XM_049092228.1 → XP_048948185.1  tight junction protein ZO-2 isoform X1

    3. XM_025423367.3 → XP_025279152.1  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NNL3
      Conserved Domains (5) summary
      cd12027
      Location:584 → 646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:680 → 859
      GuKc; Guanylate kinase homologues
      smart00228
      Location:284 → 365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:125 → 266
      RSRP; Arginine/Serine-Rich protein 1

    4. XM_049092245.1 → XP_048948202.1  tight junction protein ZO-2 isoform X10

    5. XM_049092239.1 → XP_048948196.1  tight junction protein ZO-2 isoform X7

    6. XM_049092220.1 → XP_048948177.1  tight junction protein ZO-2 isoform X4

    7. XM_049092219.1 → XP_048948176.1  tight junction protein ZO-2 isoform X3

    8. XM_049092218.1 → XP_048948175.1  tight junction protein ZO-2 isoform X2

      UniProtKB/TrEMBL
      A0A8C0LT93

    9. XM_035702316.2 → XP_035558209.1  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NNL3
      Conserved Domains (5) summary
      cd12027
      Location:584 → 646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:680 → 859
      GuKc; Guanylate kinase homologues
      smart00228
      Location:284 → 365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:125 → 266
      RSRP; Arginine/Serine-Rich protein 1

    10. XM_049092246.1 → XP_048948203.1  tight junction protein ZO-2 isoform X11

    11. XM_035702354.2 → XP_035558247.1  tight junction protein ZO-2 isoform X9

      UniProtKB/TrEMBL
      A0A8C0NF12
      Conserved Domains (5) summary
      cd12027
      Location:607 → 669
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:703 → 882
      GuKc; Guanylate kinase homologues
      smart00228
      Location:307 → 388
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:148 → 289
      RSRP; Arginine/Serine-Rich protein 1

    12. XM_025423365.3 → XP_025279150.1  tight junction protein ZO-2 isoform X6

      UniProtKB/TrEMBL
      A0A8C0NF12
      Conserved Domains (5) summary
      cd12027
      Location:607 → 669
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:703 → 882
      GuKc; Guanylate kinase homologues
      smart00228
      Location:307 → 388
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:32 → 117
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:148 → 291
      RSRP; Arginine/Serine-Rich protein 1

    13. XM_035702347.2 → XP_035558240.1  tight junction protein ZO-2 isoform X1

      UniProtKB/TrEMBL
      A0A8C0NNL3
      Conserved Domains (5) summary
      cd12027
      Location:584 → 646
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:680 → 859
      GuKc; Guanylate kinase homologues
      smart00228
      Location:284 → 365
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:9 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:125 → 266
      RSRP; Arginine/Serine-Rich protein 1

    14. XM_025423368.3 → XP_025279153.1  tight junction protein ZO-2 isoform X8

      UniProtKB/TrEMBL
      A0A8I3MEQ4, A0A8P0P9M7
      Conserved Domains (5) summary
      cd12027
      Location:611 → 673
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:707 → 886
      GuKc; Guanylate kinase homologues
      smart00228
      Location:311 → 392
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:152 → 295
      RSRP; Arginine/Serine-Rich protein 1

    15. XM_025423364.3 → XP_025279149.1  tight junction protein ZO-2 isoform X5

      UniProtKB/TrEMBL
      A0A8I3MEQ4, A0A8P0P9M7
      Conserved Domains (5) summary
      cd12027
      Location:611 → 673
      SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
      smart00072
      Location:707 → 886
      GuKc; Guanylate kinase homologues
      smart00228
      Location:311 → 392
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00992
      Location:36 → 121
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam17069
      Location:152 → 295
      RSRP; Arginine/Serine-Rich protein 1
    Nucleotide Protein
    Heading Accession and Version

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