Max Max protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Maxprovided by MGI
Official Full Name: Max proteinprovided by MGI
Primary source: MGI:MGI:96921
See related: Ensembl:ENSMUSG00000059436 AllianceGenome:MGI:96921
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Part of Myc-Max complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; lens; and upper jaw. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Orthologous to human MAX (MYC associated factor X). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 24.2), small intestine adult (RPKM 21.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 33.78 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (76984045..77009123, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (76937269..76962323, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MAX controls meiotic entry in sexually undifferentiated germ cells.
Title: MAX controls meiotic entry in sexually undifferentiated germ cells.
Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.
Title: Integrated analysis of mRNA-seq and miRNA-seq reveals the potential roles of Egr1, Rxra and Max in kidney stone disease.
SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.
Title: SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.
Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
Title: Repression of germline genes by PRC1.6 and SETDB1 in the early embryo precedes DNA methylation-mediated silencing.
MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
Title: MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer.
We also describe that B lymphocytes lacking Myc, Max, or both show upregulation of signaling pathways associated with the B-cell receptor. These data suggest that c-Myc/Max heterodimers are not essential for the initiation of a subset of important biological processes in B lymphocytes, but are required for fine-tuning the initial response after activation.
Title: Functional interplay between c-Myc and Max in B lymphocyte differentiation.
MAX associated with DNA methyltransferases (DNMTs) and the histone methyltransferase SETDB1 cooperatively control germ cell-related gene expression in embryonic stem cells.
Title: DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells.
Studies suggest that inducible MYC Associated Factor X (MAX) knockout embryonic stem cells (ESCs) provide an excellent platform for exploring the molecular mechanisms of meiosis initiation.
Title: Does MAX open up a new avenue for meiotic research?
MAX is a new regulator of meiotic onset.
Title: Loss of MAX results in meiotic entry in mouse embryonic and germline stem cells.
Max is part of protein complex that acts as a repressor of germ cell-related genes in embryonic stem cells.
Title: Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Max (e-PCR), detects polymorphism
- UniSTS:257024

AI237355 (e-PCR)
- UniSTS:261734

AA960152 (e-PCR)
- UniSTS:160218

Max (e-PCR), detects polymorphism
- UniSTS:257023

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
contributes_to DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables E-box binding	IEA Inferred from Electronic Annotation more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to starvation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in response to axon injury	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of MLL1 complex	ISO Inferred from Sequence Orthology more info
part_of MLL1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Mad-Max complex	ISO Inferred from Sequence Orthology more info
part_of Myc-Max complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Myc-Max complex	ISO Inferred from Sequence Orthology more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein max

Names: myc-associated factor X; myc-binding novel HLH/LZ protein; protein myn

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146176.2 → NP_001139648.1 protein max isoform 2

See identical proteins and their annotated locations for NP_001139648.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1 but maintains the reading frame. The encoded protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.

Source sequence(s)

AC124556

Consensus CDS

CCDS49094.1

UniProtKB/TrEMBL

Q8C4Y1

Related

ENSMUSP00000080778.6, ENSMUST00000082136.7

Conserved Domains (1) summary

cd11406
Location:15 → 83

bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins
NM_001361663.2 → NP_001348592.1 protein max isoform 3

Status: VALIDATED

Source sequence(s)

AC124556

Conserved Domains (1) summary

cd11406
Location:24 → 92

bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins
NM_001361664.2 → NP_001348593.1 protein max isoform 4

Status: VALIDATED

Source sequence(s)

AC124556
NM_001422052.1 → NP_001408981.1 protein max isoform 5

Status: VALIDATED

Source sequence(s)

AC124556

UniProtKB/TrEMBL

A0A1W2P7P4

Related

ENSMUSP00000151710.2, ENSMUST00000218640.2
NM_001422053.1 → NP_001408982.1 protein max isoform 4

Status: VALIDATED

Source sequence(s)

AC124556
NM_008558.3 → NP_032584.2 protein max isoform 1

See identical proteins and their annotated locations for NP_032584.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC124556

Consensus CDS

CCDS36479.1

UniProtKB/Swiss-Prot

B2RS19, P28574, Q8C4Y1

Related

ENSMUSP00000106025.4, ENSMUST00000110395.11

Conserved Domains (1) summary

cd11406
Location:24 → 92

bHLHzip_Max; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins