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    Map3k6 mitogen-activated protein kinase kinase kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 53608, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Map3k6provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase kinase 6provided by MGI
    Primary source
    MGI:MGI:1855691
    See related
    Ensembl:ENSMUSG00000028862 AllianceGenome:MGI:1855691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ask2; MEKK6; MAPKKK6
    Summary
    Predicted to enable ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Predicted to be involved in JNK cascade; p38MAPK cascade; and protein phosphorylation. Is expressed in heart and vibrissa. Orthologous to human MAP3K6 (mitogen-activated protein kinase kinase kinase 6). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in large intestine adult (RPKM 10.4), genital fat pad adult (RPKM 9.5) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map3k6 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132965290..132980240)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133237979..133252929)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptor 3 Neighboring gene CD164 sialomucin-like 2 Neighboring gene ficolin C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene synaptotagmin-like 1 Neighboring gene transmembrane protein 222 Neighboring gene STARR-seq mESC enhancer starr_11620

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. Tartey S, et al. J Clin Invest, 2018 May 1. PMID 29629899, Free PMC Article
    2. ASK family kinases mediate cellular stress and redox signaling to circadian clock. Imamura K, et al. Proc Natl Acad Sci U S A, 2018 Apr 3. PMID 29555767, Free PMC Article
    3. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. Iriyama T, et al. EMBO J, 2009 Apr 8. PMID 19214184, Free PMC Article
    4. Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression. Eto N, et al. Am J Pathol, 2009 Apr. PMID 19246638, Free PMC Article
    5. Rac1/osmosensing scaffold for MEKK3 contributes via phospholipase C-gamma1 to activation of the osmoprotective transcription factor NFAT5. Zhou X, et al. Proc Natl Acad Sci U S A, 2011 Jul 19. PMID 21712438, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the present study identifies SHP-1 and ASK signaling crosstalk as a critical regulator of IL-1alpha-driven inflammation and opens future avenues for finding novel drug targets to treat neutrophilic dermatosis
      Title: ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis.
    2. the ASK1/2 complex is a regulator of NLRP3 activation
      Title: ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming.
    3. Data show that deletion of either MAPKKK5 ASK1 or MAPKKK6 ASK2 in mice promoted the replication of influenza A virus in the lung.
      Title: The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.
    4. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
      Title: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC159280

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in p38MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase 6
    Names
    apoptosis signal-regulating kinase 2
    NP_057902.5
    XP_006539103.1
    XP_006539104.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016693.5 → NP_057902.5  mitogen-activated protein kinase kinase kinase 6

      Status: VALIDATED

      Source sequence(s)
      AL671882, AL837525
      Consensus CDS
      CCDS18744.1
      UniProtKB/Swiss-Prot
      A2AE93, Q0VBN3, Q9WTR2
      UniProtKB/TrEMBL
      A0A0A0MQ82
      Related
      ENSMUSP00000030677.7, ENSMUST00000030677.7
      Conserved Domains (3) summary
      smart00220
      Location:654 → 907
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06624
      Location:640 → 907
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:130 → 507
      DUF4071; Domain of unknown function (DUF4071)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132965290..132980240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539040.4 → XP_006539103.1  mitogen-activated protein kinase kinase kinase 6 isoform X1

      UniProtKB/Swiss-Prot
      A2AE93, Q0VBN3, Q9WTR2
      Conserved Domains (2) summary
      cd06624
      Location:632 → 899
      STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
      pfam13281
      Location:130 → 500
      DUF4071; Domain of unknown function (DUF4071)

    2. XM_006539041.4 → XP_006539104.1  mitogen-activated protein kinase kinase kinase 6 isoform X2

      Conserved Domains (1) summary
      pfam13281
      Location:130 → 508
      DUF4071; Domain of unknown function (DUF4071)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTR2.4 GenPept UniProtKB/Swiss-Prot:Q9WTR2

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