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    GLG1 golgi glycoprotein 1 [ Homo sapiens (human) ]

    Gene ID: 2734, updated on 3-Nov-2024

    Summary

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    Official Symbol
    GLG1provided by HGNC
    Official Full Name
    golgi glycoprotein 1provided by HGNC
    Primary source
    HGNC:HGNC:4316
    See related
    Ensembl:ENSG00000090863 MIM:600753; AllianceGenome:HGNC:4316
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CFR-1; ESL-1; MG160; MG-160
    Summary
    Predicted to enable fibroblast growth factor binding activity. Predicted to act upstream of or within several processes, including negative regulation of protein processing; negative regulation of transforming growth factor beta receptor signaling pathway; and regulation of chondrocyte differentiation. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 26.0), testis (RPKM 23.5) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GLG1 in Genome Data Viewer
    Location:
    16q23.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (74447440..74607114, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (80494088..80653847, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (74481338..74641012, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74441122-74442022 Neighboring gene uncharacterized LOC107984827 Neighboring gene C-type lectin domain family 18 member B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:74465107-74465660 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:74496013-74497212 Neighboring gene RNA, U6 small nuclear 237, pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr16:74519761-74520313 Neighboring gene NANOG hESC enhancer GRCh37_chr16:74529259-74529934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74539585-74540084 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74586439-74586940 Neighboring gene MPRA-validated peak2638 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74599495-74599996 Neighboring gene ribosomal protein S10 pseudogene 23 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:74601639-74602138 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:74654659-74655158 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 7 Neighboring gene ring finger and WD repeat domain 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7699

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study identifies NRP2 and ESL-1 as targets for polysialylation in murine microglia and human THP-1 macrophages and reveals a striking convergence in the regulation of the two polysialylated acceptors in the course of inflammatory activation. A pool of polysialylated NRP2 and ESL-1 is assembled after injury or in culture and its shedding is an early response to lipopolysaccharide-induced activation of microglia.
      Title: Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages.
    2. Our results highlight the fact that interaction between APN and ESL-1 could provide a fundamental mechanism underlying the anti-atherogenic properties of APN.
      Title: E-selectin ligand-1 (ESL-1) is a novel adiponectin binding protein on cell adhesion.
    3. circulating prostate cancer cells' rolling capacity contributes to metastasis, and that is in part controlled by ESL-1.
      Title: E-selectin ligand-1 controls circulating prostate cancer cell rolling/adhesion and metastasis.
    4. Studies indicate that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic glycoprotein ligands for endothelial P-selectin and E-selectin.
      Title: Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.
    5. expression of Cfr in the Golgi apparatus and on the plasma membrane is finely tuned through two distinct mechanisms for exhibiting different functions.
      Title: Retention in the Golgi apparatus and expression on the cell surface of Cfr/Esl-1/Glg-1/MG-160 are regulated by two distinct mechanisms.
    6. C2GnT1 gene expression and the resulting C2-O-sLe(X) carbohydrates produced mediate the adhesive and invasive behaviors of human carcinomas which may influence their metastatic potential.
      Title: C2-O-sLeX glycoproteins are E-selectin ligands that regulate invasion of human colon and hepatic carcinoma cells.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
    8. Genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: A pilot genome-wide association study of early-onset breast cancer.
    9. under hypoxia, ESL-1 is shed from activated hepatic stellate cells
      Title: Expression of E-selectin ligand-1 (CFR/ESL-1) on hepatic stellate cells: implications for leukocyte extravasation and liver metastasis.
    10. evaluated in human brain tumors exhibiting varying degrees of malignancy
      Title: Identification of MG-160, a FGF binding medial Golgi sialoglycoprotein, in brain tumors: an index of malignancy in astrocytomas.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A pilot genome-wide association study of early-onset breast cancer.
    EBI GWAS Catalog
    Meta-analysis identifies four new loci associated with testicular germ cell tumor.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with GLG1; predicted interaction to be within the Golgi PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ23319, FLJ23967, FLJ32797, DKFZp686L08213

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fibroblast growth factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bone morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of chondrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane HDA PubMed 
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    Golgi apparatus protein 1
    Names
    E-selectin ligand 1
    cysteine-rich fibroblast growth factor receptor
    golgi sialoglycoprotein MG-160

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145666.2 → NP_001139138.1  Golgi apparatus protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001139138.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC009053, AK304156, BC060822, BX648396, DA493962
      Consensus CDS
      CCDS45526.1
      UniProtKB/Swiss-Prot
      Q92896
      Related
      ENSP00000406946.2, ENST00000447066.6
      Conserved Domains (1) summary
      pfam00839
      Location:789 → 845
      Cys_rich_FGFR; Cysteine rich repeat

    2. NM_001145667.2 → NP_001139139.1  Golgi apparatus protein 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001139139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional segment in the 3' region, as compared to variant 1. The resulting isoform (3) is shorter at the C-terminus, as compared to isoform 1.
      Source sequence(s)
      AC009053, BC060822, BX648396, U64791
      Consensus CDS
      CCDS45527.1
      UniProtKB/Swiss-Prot
      B7Z8Y4, D3DUJ7, Q13221, Q6P9D1, Q92896
      Related
      ENSP00000405984.3, ENST00000422840.7
      Conserved Domains (1) summary
      pfam00839
      Location:800 → 856
      Cys_rich_FGFR; Cysteine rich repeat

    3. NM_012201.6 → NP_036333.2  Golgi apparatus protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_036333.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC009053, AK304156, BC060822, BX648396
      Consensus CDS
      CCDS32485.1
      UniProtKB/Swiss-Prot
      Q92896
      Related
      ENSP00000205061.5, ENST00000205061.9
      Conserved Domains (1) summary
      pfam00839
      Location:800 → 856
      Cys_rich_FGFR; Cysteine rich repeat

    RNA

    1. NR_027264.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an additional exon in the middle region and an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      AC009053, AK027032, AK304156, BX648396, DA493962

    2. NR_027265.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks several internal exons and has an additional segment in the 3' region, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay (NMD) candidate, and is unlikely to make a functional protein.
      Source sequence(s)
      AC009053, BC031836, BC060822, BX648396, DA493962

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      74447440..74607114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      80494088..80653847 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92896.2 GenPept UniProtKB/Swiss-Prot:Q92896

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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