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    TMEM131L transmembrane 131 like [ Homo sapiens (human) ]

    Gene ID: 23240, updated on 3-Apr-2024

    Summary

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    Official Symbol
    TMEM131Lprovided by HGNC
    Official Full Name
    transmembrane 131 likeprovided by HGNC
    Primary source
    HGNC:HGNC:29146
    See related
    Ensembl:ENSG00000121210 MIM:616243; AllianceGenome:HGNC:29146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0922
    Summary
    Involved in negative regulation of canonical Wnt signaling pathway and negative regulation of immature T cell proliferation in thymus. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lymph node (RPKM 22.3), bone marrow (RPKM 15.4) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    4q31.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (153466360..153636711)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (156790800..156961149)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (154387512..154557863)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22052 Neighboring gene annexin A2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 419, pseudogene Neighboring gene meiotic nuclear divisions 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22054 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15762 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154388523-154389188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390454-154390954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154390955-154391455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22060 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22062 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22065 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22066 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154415607-154416604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22068 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:154433973-154434472 Neighboring gene NANOG hESC enhancer GRCh37_chr4:154442146-154442647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22069 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:154444154-154444994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15763 Neighboring gene uncharacterized LOC105377498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154455569-154456145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:154456146-154456721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:154457236-154457741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15764 Neighboring gene toll like receptor 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:154561385-154561884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15766 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15767 Neighboring gene WD repeat domain 45 pseudogene 1 Neighboring gene toll like receptor 2 Neighboring gene ring finger protein 175

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of TMEM131L as a novel regulator of thymocyte proliferation in humans. Maharzi N, et al. J Immunol, 2013 Jun 15. PMID 23690469
    2. Evolutionary conservation of Notch signaling inhibition by TMEM131L overexpression. Szuplewski S, et al. Biochem Biophys Res Commun, 2017 May 13. PMID 28347816
    3. Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination. Fan X, et al. Int J Mol Sci, 2021 Sep 28. PMID 34638806, Free PMC Article
    4. Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. Navare AT, et al. J Cell Biol, 2022 Nov 7. PMID 36305789, Free PMC Article
    5. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Low SK, et al. Cancer Sci, 2013 Aug. PMID 23648065, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of KIAA0922 by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with KIAA0922 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10592, DKFZp586H1322

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of immature T cell proliferation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 131-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001131007.2 → NP_001124479.1  transmembrane protein 131-like isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (2).
      Source sequence(s)
      AK092270, AK096538, AK308448, BC044932
      Consensus CDS
      CCDS47148.1
      UniProtKB/TrEMBL
      H0Y2M0
      Related
      ENSP00000386787.3, ENST00000409959.8
      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    2. NM_015196.4 → NP_056011.3  transmembrane protein 131-like isoform 2 precursor

      See identical proteins and their annotated locations for NP_056011.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1.
      Source sequence(s)
      BC131505, BQ270562, DA778851
      Consensus CDS
      CCDS3783.2
      UniProtKB/Swiss-Prot
      A2VDJ0, B3KRV3, D3DP10, Q7LGA7, Q86Y92, Q8WU56, Q9H065, Q9Y2D7
      UniProtKB/TrEMBL
      H0Y2M0
      Related
      ENSP00000386574.3, ENST00000409663.7
      Conserved Domains (2) summary
      pfam19532
      Location:185 → 1609
      TMEM131_like; Transmembrane protein 131-like
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      153466360..153636711
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047449899.1 → XP_047305855.1  transmembrane protein 131-like isoform X1

    2. XM_011531780.2 → XP_011530082.1  transmembrane protein 131-like isoform X4

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:120 → 203
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    3. XM_047449901.1 → XP_047305857.1  transmembrane protein 131-like isoform X3

    4. XM_047449902.1 → XP_047305858.1  transmembrane protein 131-like isoform X6

    5. XM_047449917.1 → XP_047305873.1  transmembrane protein 131-like isoform X25

    6. XM_011531783.2 → XP_011530085.1  transmembrane protein 131-like isoform X28

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:120 → 203
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    7. XM_047449920.1 → XP_047305876.1  transmembrane protein 131-like isoform X29

    8. XM_047449900.1 → XP_047305856.1  transmembrane protein 131-like isoform X2

    9. XM_011531781.2 → XP_011530083.1  transmembrane protein 131-like isoform X5

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:120 → 203
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    10. XM_047449903.1 → XP_047305859.1  transmembrane protein 131-like isoform X7

    11. XM_047449918.1 → XP_047305874.1  transmembrane protein 131-like isoform X26

    12. XM_047449919.1 → XP_047305875.1  transmembrane protein 131-like isoform X27

    13. XM_047449904.1 → XP_047305860.1  transmembrane protein 131-like isoform X8

    14. XM_047449908.1 → XP_047305864.1  transmembrane protein 131-like isoform X14

    15. XM_047449909.1 → XP_047305865.1  transmembrane protein 131-like isoform X15

    16. XM_047449905.1 → XP_047305861.1  transmembrane protein 131-like isoform X9

    17. XM_047449910.1 → XP_047305866.1  transmembrane protein 131-like isoform X16

    18. XM_024453956.2 → XP_024309724.1  transmembrane protein 131-like isoform X10

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    19. XM_047449906.1 → XP_047305862.1  transmembrane protein 131-like isoform X11

    20. XM_017007925.2 → XP_016863414.1  transmembrane protein 131-like isoform X17

      UniProtKB/TrEMBL
      H0Y2M0

    21. XM_047449921.1 → XP_047305877.1  transmembrane protein 131-like isoform X30

    22. XM_047449923.1 → XP_047305879.1  transmembrane protein 131-like isoform X32

      Related
      ENSP00000240487.5, ENST00000240487.5

    23. XM_047449925.1 → XP_047305881.1  transmembrane protein 131-like isoform X34

    24. XM_024453957.2 → XP_024309725.1  transmembrane protein 131-like isoform X12

      UniProtKB/TrEMBL
      H0Y2M0
      Conserved Domains (1) summary
      cl13764
      Location:91 → 174
      ASH; Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin

    25. XM_047449907.1 → XP_047305863.1  transmembrane protein 131-like isoform X13

    26. XM_017007926.2 → XP_016863415.1  transmembrane protein 131-like isoform X18

      UniProtKB/TrEMBL
      H0Y2M0

    27. XM_047449922.1 → XP_047305878.1  transmembrane protein 131-like isoform X31

    28. XM_047449924.1 → XP_047305880.1  transmembrane protein 131-like isoform X33

    29. XM_047449926.1 → XP_047305882.1  transmembrane protein 131-like isoform X35

    30. XM_047449911.1 → XP_047305867.1  transmembrane protein 131-like isoform X19

    31. XM_047449913.1 → XP_047305869.1  transmembrane protein 131-like isoform X21

    32. XM_047449915.1 → XP_047305871.1  transmembrane protein 131-like isoform X23

    33. XM_047449927.1 → XP_047305883.1  transmembrane protein 131-like isoform X36

    34. XM_047449912.1 → XP_047305868.1  transmembrane protein 131-like isoform X20

    35. XM_047449914.1 → XP_047305870.1  transmembrane protein 131-like isoform X22

    36. XM_047449916.1 → XP_047305872.1  transmembrane protein 131-like isoform X24

    37. XM_047449928.1 → XP_047305884.1  transmembrane protein 131-like isoform X37

    38. XM_047449929.1 → XP_047305885.1  transmembrane protein 131-like isoform X38

    39. XM_047449930.1 → XP_047305886.1  transmembrane protein 131-like isoform X39

    40. XM_024453958.2 → XP_024309726.1  transmembrane protein 131-like isoform X40

      UniProtKB/TrEMBL
      B3KU55

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      156790800..156961149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349416.1 → XP_054205391.1  transmembrane protein 131-like isoform X1

    2. XM_054349419.1 → XP_054205394.1  transmembrane protein 131-like isoform X4

    3. XM_054349425.1 → XP_054205400.1  transmembrane protein 131-like isoform X10

    4. XM_054349426.1 → XP_054205401.1  transmembrane protein 131-like isoform X11

    5. XM_054349432.1 → XP_054205407.1  transmembrane protein 131-like isoform X17

    6. XM_054349445.1 → XP_054205420.1  transmembrane protein 131-like isoform X30

    7. XM_054349447.1 → XP_054205422.1  transmembrane protein 131-like isoform X32

    8. XM_054349449.1 → XP_054205424.1  transmembrane protein 131-like isoform X34

    9. XM_054349427.1 → XP_054205402.1  transmembrane protein 131-like isoform X12

    10. XM_054349428.1 → XP_054205403.1  transmembrane protein 131-like isoform X13

    11. XM_054349433.1 → XP_054205408.1  transmembrane protein 131-like isoform X18

    12. XM_054349446.1 → XP_054205421.1  transmembrane protein 131-like isoform X31

    13. XM_054349448.1 → XP_054205423.1  transmembrane protein 131-like isoform X33

    14. XM_054349450.1 → XP_054205425.1  transmembrane protein 131-like isoform X35

    15. XM_054349434.1 → XP_054205409.1  transmembrane protein 131-like isoform X19

    16. XM_054349436.1 → XP_054205411.1  transmembrane protein 131-like isoform X21

    17. XM_054349438.1 → XP_054205413.1  transmembrane protein 131-like isoform X23

    18. XM_054349451.1 → XP_054205426.1  transmembrane protein 131-like isoform X36

    19. XM_054349435.1 → XP_054205410.1  transmembrane protein 131-like isoform X20

    20. XM_054349437.1 → XP_054205412.1  transmembrane protein 131-like isoform X22

    21. XM_054349439.1 → XP_054205414.1  transmembrane protein 131-like isoform X24

    22. XM_054349452.1 → XP_054205427.1  transmembrane protein 131-like isoform X37

    23. XM_054349418.1 → XP_054205393.1  transmembrane protein 131-like isoform X3

    24. XM_054349421.1 → XP_054205396.1  transmembrane protein 131-like isoform X6

    25. XM_054349453.1 → XP_054205428.1  transmembrane protein 131-like isoform X38

    26. XM_054349454.1 → XP_054205429.1  transmembrane protein 131-like isoform X39

    27. XM_054349440.1 → XP_054205415.1  transmembrane protein 131-like isoform X25

    28. XM_054349443.1 → XP_054205418.1  transmembrane protein 131-like isoform X28

    29. XM_054349444.1 → XP_054205419.1  transmembrane protein 131-like isoform X29

    30. XM_054349420.1 → XP_054205395.1  transmembrane protein 131-like isoform X5

    31. XM_054349417.1 → XP_054205392.1  transmembrane protein 131-like isoform X2

    32. XM_054349422.1 → XP_054205397.1  transmembrane protein 131-like isoform X7

    33. XM_054349441.1 → XP_054205416.1  transmembrane protein 131-like isoform X26

    34. XM_054349442.1 → XP_054205417.1  transmembrane protein 131-like isoform X27

    35. XM_054349423.1 → XP_054205398.1  transmembrane protein 131-like isoform X8

    36. XM_054349429.1 → XP_054205404.1  transmembrane protein 131-like isoform X14

    37. XM_054349430.1 → XP_054205405.1  transmembrane protein 131-like isoform X15

    38. XM_054349424.1 → XP_054205399.1  transmembrane protein 131-like isoform X9

    39. XM_054349431.1 → XP_054205406.1  transmembrane protein 131-like isoform X16

    40. XM_054349455.1 → XP_054205430.1  transmembrane protein 131-like isoform X41

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2VDJ0.2 GenPept UniProtKB/Swiss-Prot:A2VDJ0

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