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    PAK5 p21 (RAC1) activated kinase 5 [ Gallus gallus (chicken) ]

    Gene ID: 416734, updated on 6-Jun-2024

    Summary

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    Symbol
    PAK5provided by CGNC
    Full Name
    p21 (RAC1) activated kinase 5provided by CGNC
    Primary source
    CGNC:6796
    See related
    Ensembl:ENSGALG00010018367
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PAK7
    Orthologs
    human mouse all
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    Genomic context

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    See PAK5 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (13322621..13638915)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (13232827..13549171)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene SLX4 interacting protein Neighboring gene uncharacterized LOC124417870 Neighboring gene jagged canonical Notch ligand 1 Neighboring gene MKKS centrosomal shuttling protein Neighboring gene synaptosome associated protein 25 Neighboring gene D-beta-hydroxybutyrate dehydrogenase, mitochondrial-like Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene uncharacterized LOC121110387 Neighboring gene lysosomal associated membrane protein family member 5 Neighboring gene phospholipase C beta 4 Neighboring gene uncharacterized LOC107052866 Neighboring gene phospholipase C beta 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 5
    Names
    p21 protein (Cdc42/Rac)-activated kinase 7
    p21(CDKN1A)-activated kinase 7
    serine/threonine-protein kinase PAK 7
    NP_001385143.1
    XP_040552881.2
    XP_040552882.1
    XP_040552883.1
    XP_046769374.1
    XP_046769375.1
    XP_046769376.1
    XP_046769377.1
    XP_046769378.1
    XP_046769379.1
    XP_046769380.1
    XP_046769381.1
    XP_046769382.1
    XP_046769383.1
    XP_046769384.1
    XP_046769385.1
    XP_046769386.1
    XP_046769387.1
    XP_046769388.1
    XP_046769389.1
    XP_046794583.1
    XP_046794584.1
    XP_046794585.1
    XP_046794586.1
    XP_046794587.1
    XP_046794588.1
    XP_046794589.1
    XP_046794590.1
    XP_046794591.1
    XP_046794592.1
    XP_046794593.1
    XP_046794595.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398214.1 → NP_001385143.1  serine/threonine-protein kinase PAK 5

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000062
      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7
      Conserved Domains (2) summary
      cd01093
      Location:56 → 102
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:477 → 768
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13322621..13638915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046938631.1 → XP_046794587.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    2. XM_046938634.1 → XP_046794590.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    3. XM_046938630.1 → XP_046794586.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    4. XM_046938633.1 → XP_046794589.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    5. XM_046938632.1 → XP_046794588.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    6. XM_046938628.1 → XP_046794584.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    7. XM_046938627.1 → XP_046794583.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZF2

    8. XM_040696947.2 → XP_040552881.2  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZF2

    9. XM_040696948.2 → XP_040552882.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7
      Conserved Domains (2) summary
      cd01093
      Location:56 → 102
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:477 → 768
      PKc_like; Protein Kinases, catalytic domain

    10. XM_046938639.1 → XP_046794595.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    11. XM_046938629.1 → XP_046794585.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7
      Related
      ENSGALP00010026386.1, ENSGALT00010044345.1

    12. XM_046938635.1 → XP_046794591.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    13. XM_040696949.2 → XP_040552883.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7
      Related
      ENSGALP00010026383.1, ENSGALT00010044340.1
      Conserved Domains (2) summary
      cd01093
      Location:56 → 102
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:477 → 768
      PKc_like; Protein Kinases, catalytic domain

    14. XM_046938636.1 → XP_046794592.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    15. XM_046938637.1 → XP_046794593.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2, E1BWY7

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13232827..13549171
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046913425.1 → XP_046769381.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    2. XM_046913428.1 → XP_046769384.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    3. XM_046913423.1 → XP_046769379.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    4. XM_046913427.1 → XP_046769383.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    5. XM_046913426.1 → XP_046769382.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    6. XM_046913421.1 → XP_046769377.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    7. XM_046913418.1 → XP_046769374.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZF2

    8. XM_046913419.1 → XP_046769375.1  serine/threonine-protein kinase PAK 5 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YZF2

    9. XM_046913420.1 → XP_046769376.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    10. XM_046913431.1 → XP_046769387.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    11. XM_046913422.1 → XP_046769378.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    12. XM_046913429.1 → XP_046769385.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    13. XM_046913433.1 → XP_046769389.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    14. XM_046913424.1 → XP_046769380.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    15. XM_046913430.1 → XP_046769386.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    16. XM_046913432.1 → XP_046769388.1  serine/threonine-protein kinase PAK 5 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YZF2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001199409.2: Suppressed sequence

      Description
      NM_001199409.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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