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    Tnfaip8l2 tumor necrosis factor, alpha-induced protein 8-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 69769, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tnfaip8l2provided by MGI
    Official Full Name
    tumor necrosis factor, alpha-induced protein 8-like 2provided by MGI
    Primary source
    MGI:MGI:1917019
    See related
    Ensembl:ENSMUSG00000013707 AllianceGenome:MGI:1917019
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TIPE2; 1810019A08Rik
    Summary
    Acts upstream of or within negative regulation of T cell activation and negative regulation of inflammatory response. Located in cytoplasm. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human TNFAIP8L2 (TNF alpha induced protein 8 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 43.4), thymus adult (RPKM 22.0) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tnfaip8l2 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95046832..95051581, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95139521..95142416, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94937828-94938011 Neighboring gene sodium channel modifier 1 Neighboring gene LysM, putative peptidoglycan-binding, domain containing 1 Neighboring gene microRNA 8099-1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94945477-94945712 Neighboring gene predicted gene 9169 Neighboring gene STARR-seq mESC enhancer starr_08369 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2. Fayngerts SA, et al. Nat Immunol, 2017 Dec. PMID 29058702, Free PMC Article
    2. Gene delivery of TIPE2 attenuates collagen-induced arthritis by modulating inflammation. Zhou J, et al. Int Immunopharmacol, 2020 Feb. PMID 31863922
    3. Loss of TIPE2 Has Opposing Effects on the Pathogenesis of Autoimmune Diseases. Liu R, et al. Front Immunol, 2019. PMID 31616442, Free PMC Article
    4. Tumor Necrosis Factor-α-Induced Protein 8-like 2 Downregulation Reduces CD4⁺ T Lymphocyte Apoptosis in Mice with Thermal Injury. Huang H, et al. Med Sci Monit, 2019 Oct 8. PMID 31591376, Free PMC Article
    5. TIPE2 ameliorates lipopolysaccharide-induced apoptosis and inflammation in acute lung injury. Wu X, et al. Inflamm Res, 2019 Nov. PMID 31486847, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence.
      Title: TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence.
    2. TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-gamma-mediated ferroptosis.
      Title: TIPE2 knockout reduces myocardial cell damage by inhibiting IFN-γ-mediated ferroptosis.
    3. TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
      Title: TIPE2 attenuates neuroinflammation and brain injury through Bcl-2/Bax/cleaved caspase-3 apoptotic pathways after intracerebral hemorrhage in mice.
    4. Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
      Title: Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Ameliorates Cardiac Hypertrophy by Targeting TLR4 in Macrophages.
    5. TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
      Title: TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer.
    6. Tumor Necrosis Factor-alpha-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
      Title: Tumor Necrosis Factor-α-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer.
    7. TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
      Title: TIPE2 is a checkpoint of natural killer cell maturation and antitumor immunity.
    8. TNF-alpha-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
      Title: TNF-α-induced protein 8-like 2 negatively regulates the immune function of dendritic cells by suppressing autophagy via the TAK1/JNK pathway in septic mice.
    9. TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
      Title: TIPE2 inhibits PDGF-BB-induced phenotype switching in airway smooth muscle cells through the PI3K/Akt signaling pathway.
    10. Tumor Necrosis Factor alpha-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
      Title: Tumor Necrosis Factor α-Induced Protein 8-Like 2 Alleviates Nonalcoholic Fatty Liver Disease Through Suppressing Transforming Growth Factor Beta-Activated Kinase 1 Activation.
    Submit: New GeneRIF Correction See all GeneRIFs (50)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tumor necrosis factor alpha-induced protein 8-like protein 2
    Names
    TNF alpha-induced protein 8-like protein 2
    TNFAIP8-like protein 2
    tumor necrosis factor, alpha-induced protein 8-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027206.3 → NP_081482.1  tumor necrosis factor alpha-induced protein 8-like protein 2

      See identical proteins and their annotated locations for NP_081482.1

      Status: VALIDATED

      Source sequence(s)
      AC131769
      Consensus CDS
      CCDS17603.1
      UniProtKB/Swiss-Prot
      Q9D8Y7
      Related
      ENSMUSP00000013851.4, ENSMUST00000013851.4
      Conserved Domains (1) summary
      pfam05527
      Location:25 → 177
      DUF758; Domain of unknown function (DUF758)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95046832..95051581 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502040.5 → XP_006502103.1  tumor necrosis factor alpha-induced protein 8-like protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006502103.1

      UniProtKB/Swiss-Prot
      Q9D8Y7
      Conserved Domains (1) summary
      pfam05527
      Location:25 → 177
      DUF758; Domain of unknown function (DUF758)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8Y7.1 GenPept UniProtKB/Swiss-Prot:Q9D8Y7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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