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    FAS Fas cell surface death receptor [ Gallus gallus (chicken) ]

    Gene ID: 395274, updated on 17-Aug-2024

    Summary

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    Symbol
    FASprovided by CGNC
    Full Name
    Fas cell surface death receptorprovided by CGNC
    Primary source
    CGNC:4779
    See related
    Ensembl:ENSGALG00010022081
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See FAS in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (20018484..20030805)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (20005428..20017749)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene lipase member M-like 4 Neighboring gene STAM binding protein like 1 Neighboring gene actin, alpha 2, smooth muscle, aorta Neighboring gene cholesterol 25-hydroxylase Neighboring gene lipase A, lysosomal acid type

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway. Bae WY, et al. Laryngoscope, 2008 Sep. PMID 18758324
    2. The effects of the polymorphism in exon 3 of the FAS gene on the death of chicken embryos during the incubation period. Wu JJ, et al. Anim Genet, 2008 Oct. PMID 18652598
    3. Expression and regulation of Fas antigen and tumor necrosis factor receptor type I in hen granulosa cells. Bridgham JT, et al. Biol Reprod, 2001 Sep. PMID 11514335
    4. Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability. Rengaraj D, et al. Sci Rep, 2022 Jan 7. PMID 34997179, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAS from the extrinsic apoptosis pathway and BAK1 from the intrinsic apoptosis pathway shows higher fold downregulation in EGK.X blastoderms and primordial germ cells compared to chicken embryonic fibroblasts.
      Title: Chicken blastoderms and primordial germ cells possess a higher expression of DNA repair genes and lower expression of apoptosis genes to preserve their genome stability.
    2. The results showed that there were significant (P < 0.05) genotypic differences between dead and normally developing embryos for the FAS gene polymorphism, a SNP in exon 3 (NC_006093.2:g.6514A>C, rs15793179).
      Title: The effects of the polymorphism in exon 3 of the FAS gene on the death of chicken embryos during the incubation period.
    3. Blocking the Fas-FasL signaling pathway could be considered as a method for preventing secondary degeneration of SGNs.
      Title: Secondary apoptosis of spiral ganglion cells induced by aminoglycoside: Fas-Fas ligand signaling pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables tumor necrosis factor receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation-induced cell death of T cells IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in motor neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in necroptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tumor necrosis factor receptor superfamily member 6
    Names
    Fas (TNF receptor superfamily, member 6)
    fas antigen
    fas ligand receptor soluble form

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199487.2 → NP_001186416.2  tumor necrosis factor receptor superfamily member 6 precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000231
      UniProtKB/TrEMBL
      A0A8V0ZU18, Q9DGH7
      Related
      ENSGALP00010032343.1, ENSGALT00010053693.1
      Conserved Domains (3) summary
      cd08316
      Location:202 → 295
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd00185
      Location:84 → 126
      TNFRSF; CRD2 [structural motif]
      cl22855
      Location:40 → 167
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      20018484..20030805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015288355.4 → XP_015143841.2  tumor necrosis factor receptor superfamily member 6 isoform X4

      Conserved Domains (3) summary
      cd08316
      Location:239 → 332
      Death_FAS_TNFRSF6; Death domain of FAS or TNF receptor superfamily member 6
      cd00185
      Location:34 → 66
      TNFRSF; CRD1 [structural motif]
      cl22855
      Location:25 → 177
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    2. XM_015288351.4 → XP_015143837.4  tumor necrosis factor receptor superfamily member 6 isoform X1

    3. XM_015288354.4 → XP_015143840.4  tumor necrosis factor receptor superfamily member 6 isoform X3

    4. XM_015288353.4 → XP_015143839.4  tumor necrosis factor receptor superfamily member 6 isoform X2

      UniProtKB/TrEMBL
      Q9DGH8

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      20005428..20017749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046919846.1 → XP_046775802.1  tumor necrosis factor receptor superfamily member 6 isoform X4

    2. XM_046919842.1 → XP_046775798.1  tumor necrosis factor receptor superfamily member 6 isoform X1

    3. XM_046919845.1 → XP_046775801.1  tumor necrosis factor receptor superfamily member 6 isoform X3

    4. XM_046919844.1 → XP_046775800.1  tumor necrosis factor receptor superfamily member 6 isoform X2

      UniProtKB/TrEMBL
      Q9DGH8
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials