Ano9 anoctamin 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ano9provided by MGI
Official Full Name: anoctamin 9provided by MGI
Primary source: MGI:MGI:1918595
See related: Ensembl:ENSMUSG00000054662 AllianceGenome:MGI:1918595
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tp53i5; Tmem16j; Trp53i5; 5430425C04Rik
Summary: Enables calcium channel activity and phospholipid scramblase activity. Involved in sensory perception of smell. Acts upstream of or within calcium activated phospholipid scrambling and establishment of localization in cell. Located in endoplasmic reticulum and plasma membrane. Is expressed in epithelium; genital tubercle mesenchyme; rib cartilage condensation; and skin. Orthologous to human ANO9 (anoctamin 9). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 44.3), duodenum adult (RPKM 20.0) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.37 cM

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140681125..140697719, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141101212..141117806, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.
Title: Amplification of olfactory signals by Anoctamin 9 is important for mammalian olfaction.
ANO9 is a cation channel activated by a cAMP/PKA pathway and could play a role in intestine function.
Title: Anoctamin 9/TMEM16J is a cation channel activated by cAMP/PKA signal.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride channel inhibitor activity	IEA Inferred from Electronic Annotation more info
enables chloride channel inhibitor activity	ISO Inferred from Sequence Orthology more info
NOT enables intracellularly calcium-gated chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly calcium-gated chloride channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly calcium-gated chloride channel activity	ISO Inferred from Sequence Orthology more info
enables phospholipid scramblase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium activated galactosylceramide scrambling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium activated phosphatidylcholine scrambling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium activated phosphatidylserine scrambling	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of smell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: anoctamin-9

Names: Trp53 inducible protein 5; transformation related protein 53 inducible protein 5; transmembrane protein 16J; tumor protein p53 inducible protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178381.3 → NP_848468.2 anoctamin-9

See identical proteins and their annotated locations for NP_848468.2

Status: PROVISIONAL

Source sequence(s)

AC109272, BB158112, BY717147, CF896275

Consensus CDS

CCDS52438.1

UniProtKB/Swiss-Prot

P86044

Related

ENSMUSP00000067689.8, ENSMUST00000067836.9

Conserved Domains (2) summary

pfam04547
Location:174 → 730

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:105 → 171

Anoct_dimer; Dimerization domain of Ca+-activated chloride-channel, anoctamin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

140681125..140697719 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006536248.4 → XP_006536311.2 anoctamin-9 isoform X1

Conserved Domains (2) summary

pfam04547
Location:192 → 747

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:123 → 189

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin
XM_006536250.2 → XP_006536313.1 anoctamin-9 isoform X3

Conserved Domains (1) summary

pfam04547
Location:30 → 585

Anoctamin; Calcium-activated chloride channel
XM_011249856.4 → XP_011248158.1 anoctamin-9 isoform X4

Related

ENSMUST00000211515.2

Conserved Domains (1) summary

pfam04547
Location:23 → 499

Anoctamin; Calcium-activated chloride channel
XM_006536249.3 → XP_006536312.2 anoctamin-9 isoform X2

Conserved Domains (2) summary

pfam04547
Location:192 → 632

Anoctamin; Calcium-activated chloride channel

pfam16178
Location:123 → 189

Anoct_dimer; dimerization domain of Ca+-activated chloride-channel, anoctamin