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    GREP1 glycine rich extracellular protein 1 [ Homo sapiens (human) ]

    Gene ID: 283875, updated on 10-Oct-2024

    Summary

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    Official Symbol
    GREP1provided by HGNC
    Official Full Name
    glycine rich extracellular protein 1provided by HGNC
    Primary source
    HGNC:HGNC:27549
    See related
    Ensembl:ENSG00000262152 AllianceGenome:HGNC:27549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G029442; LINC00514; LA16c-380H5.1; LA16c-380H5.3
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See GREP1 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2988262..3002011)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3014944..3028691)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3038263..3052012)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3015093-3016052 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3018331-3019320 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7093 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7094 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3021603-3022419 Neighboring gene progestin and adipoQ receptor family member 4 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3029137-3030013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3030014-3030889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3030890-3031766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3032811-3033312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7098 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3033737-3033923 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3037455-3038406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3038407-3039356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3043721-3044222 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3045542-3046514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3048182-3048682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3048683-3049183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3051481-3052017 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr16:3053764-3054722 Neighboring gene Sharpr-MPRA regulatory region 8596 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3057599-3058558 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3058559-3059516 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:3061783-3062608 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:3064184-3064351 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:3065208-3065772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3066992-3067588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:3067589-3068185 Neighboring gene claudin 9 Neighboring gene claudin 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway. Zhu Y, et al. Bioengineered, 2022 May. PMID 35653786, Free PMC Article
    2. Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Prensner JR, et al. Nat Biotechnol, 2021 Jun. PMID 33510483, Free PMC Article
    3. Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression. Han Q, et al. J Exp Clin Cancer Res, 2020 Aug 8. PMID 32771045, Free PMC Article
    4. The long noncoding RNA landscape of neuroendocrine prostate cancer and its clinical implications. Ramnarine VR, et al. Gigascience, 2018 Jun 1. PMID 29757368, Free PMC Article
    5. LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR‑378a‑5p to enhance SPHK1 expression. Wang X, et al. Int J Oncol, 2021 Nov. PMID 34533201, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/beta-catenin signaling pathway.
      Title: LINC00514 facilitates cell proliferation, migration, invasion, and epithelial-mesenchymal transition in non-small cell lung cancer by acting on the Wnt/β-catenin signaling pathway.
    2. LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR378a5p to enhance SPHK1 expression.
      Title: LINC00514 promotes lipogenesis and tumor progression in esophageal squamous cell carcinoma by sponging miR‑378a‑5p to enhance SPHK1 expression.
    3. LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS.
      Title: LINC00514 promotes gastric cancer cell growth and EMT progression via miR-204-3p/KRAS.
    4. Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression.
      Title: Long noncoding RNA LINC00514 accelerates pancreatic cancer progression by acting as a ceRNA of miR-28-5p to upregulate Rap1b expression.
    5. LINC00514 promoted CDC23 expression via restraining miR-204-3p activity, leading to papillary thyroid cancer progression.
      Title: Silencing of lncRNA LINC00514 inhibits the malignant behaviors of papillary thyroid cancer through miR-204-3p/CDC23 axis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ46402

    General protein information

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    Preferred Names
    glycine-rich extracellular protein 1
    Names
    long intergenic non-protein coding RNA 514

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001396456.1 → NP_001383385.1  glycine-rich extracellular protein 1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004233
      UniProtKB/TrEMBL
      A0AAQ5BID0
      Related
      ENSP00000520374.1, ENST00000715180.1

    2. NM_001396457.1 → NP_001383386.1  glycine-rich extracellular protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004233
      UniProtKB/Swiss-Prot
      A0A0J9YXV3

    3. NM_001396458.1 → NP_001383387.1  glycine-rich extracellular protein 1 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC004233
      Related
      ENSP00000488558.1, ENST00000573315.2

    4. NM_001396459.1 → NP_001383388.1  glycine-rich extracellular protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC004233

    5. NM_001396460.1 → NP_001383389.1  glycine-rich extracellular protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC004233
      UniProtKB/TrEMBL
      A0AAQ5BID5
      Related
      ENSP00000520375.1, ENST00000715183.1

    6. NM_001396461.1 → NP_001383390.1  glycine-rich extracellular protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC004233

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      2988262..3002011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047433975.1 → XP_047289931.1  glycine-rich extracellular protein 1 isoform X15

    2. XM_047433976.1 → XP_047289932.1  glycine-rich extracellular protein 1 isoform X15

    3. XM_047433969.1 → XP_047289925.1  glycine-rich extracellular protein 1 isoform X9

    4. XM_047433960.1 → XP_047289916.1  glycine-rich extracellular protein 1 isoform X1

    5. XM_047433963.1 → XP_047289919.1  glycine-rich extracellular protein 1 isoform X4

    6. XM_047433968.1 → XP_047289924.1  glycine-rich extracellular protein 1 isoform X8

    7. XM_047433970.1 → XP_047289926.1  glycine-rich extracellular protein 1 isoform X10

    8. XM_047433971.1 → XP_047289927.1  glycine-rich extracellular protein 1 isoform X11

    9. XM_047433966.1 → XP_047289922.1  glycine-rich extracellular protein 1 isoform X7

    10. XM_047433972.1 → XP_047289928.1  glycine-rich extracellular protein 1 isoform X12

    11. XM_047433973.1 → XP_047289929.1  glycine-rich extracellular protein 1 isoform X13

    12. XM_047433961.1 → XP_047289917.1  glycine-rich extracellular protein 1 isoform X2

    13. XM_047433974.1 → XP_047289930.1  glycine-rich extracellular protein 1 isoform X14

    14. XM_047433965.1 → XP_047289921.1  glycine-rich extracellular protein 1 isoform X6

    15. XM_047433964.1 → XP_047289920.1  glycine-rich extracellular protein 1 isoform X5

    16. XM_047433962.1 → XP_047289918.1  glycine-rich extracellular protein 1 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      3014944..3028691
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054380126.1 → XP_054236101.1  glycine-rich extracellular protein 1 isoform X15

    2. XM_054380121.1 → XP_054236096.1  glycine-rich extracellular protein 1 isoform X9

    3. XM_054380114.1 → XP_054236089.1  glycine-rich extracellular protein 1 isoform X1

    4. XM_054380117.1 → XP_054236092.1  glycine-rich extracellular protein 1 isoform X4

    5. XM_054380122.1 → XP_054236097.1  glycine-rich extracellular protein 1 isoform X10

    6. XM_054380123.1 → XP_054236098.1  glycine-rich extracellular protein 1 isoform X11

    7. XM_054380120.1 → XP_054236095.1  glycine-rich extracellular protein 1 isoform X7

    8. XM_054380124.1 → XP_054236099.1  glycine-rich extracellular protein 1 isoform X12

    9. XM_054380125.1 → XP_054236100.1  glycine-rich extracellular protein 1 isoform X13

    10. XM_054380115.1 → XP_054236090.1  glycine-rich extracellular protein 1 isoform X2

    11. XM_054380119.1 → XP_054236094.1  glycine-rich extracellular protein 1 isoform X6

    12. XM_054380118.1 → XP_054236093.1  glycine-rich extracellular protein 1 isoform X5

    13. XM_054380116.1 → XP_054236091.1  glycine-rich extracellular protein 1 isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_033861.1: Suppressed sequence

      Description
      NR_033861.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    2. NR_110947.1: Suppressed sequence

      Description
      NR_110947.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    3. NR_110948.1: Suppressed sequence

      Description
      NR_110948.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    4. NR_110949.1: Suppressed sequence

      Description
      NR_110949.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0J9YXV3.1 GenPept UniProtKB/Swiss-Prot:A0A0J9YXV3

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