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    MECOM MDS1 and EVI1 complex locus [ Neogale vison (American mink) ]

    Gene ID: 122908678, updated on 22-Mar-2024

    Summary

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    Gene symbol
    MECOM
    Gene description
    MDS1 and EVI1 complex locus
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Neogale vison
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae; Mustelinae; Neogale
    Also known as
    E7EQ57
    Orthologs
    human mouse all
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    Genomic context

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    See MECOM in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    100 current ASM_NN_V1 (GCF_020171115.1) 6 NC_058096.1 (93483982..94031071, complement)

    Chromosome 6 - NC_058096.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S6-like Neighboring gene EGF-like and EMI domain-containing protein 1 Neighboring gene U4 spliceosomal RNA Neighboring gene uncharacterized LOC122910476 Neighboring gene actin related protein T3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_058096.1 Chromosome 6 Reference ASM_NN_V1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K9 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase MECOM

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Neovison vison Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM_NN_V1 Primary Assembly

    Genomic

    1. NC_058096.1 Reference ASM_NN_V1 Primary Assembly

      Range
      93483982..94031071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_044251750.1 → XP_044107685.1  histone-lysine N-methyltransferase MECOM isoform X9

      Conserved Domains (3) summary
      COG5048
      Location:289 → 631
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:590 → 610
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins

    2. XM_044251742.1 → XP_044107677.1  histone-lysine N-methyltransferase MECOM isoform X4

      UniProtKB/TrEMBL
      A0A8C7B4R0
      Conserved Domains (4) summary
      PHA00733
      Location:845 → 964
      PHA00733; hypothetical protein
      COG5189
      Location:302 → 395
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:914 → 934
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins

    3. XM_044251740.1 → XP_044107675.1  histone-lysine N-methyltransferase MECOM isoform X2

      Conserved Domains (4) summary
      PHA00733
      Location:877 → 973
      PHA00733; hypothetical protein
      COG5189
      Location:302 → 395
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:923 → 943
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins

    4. XM_044251749.1 → XP_044107684.1  histone-lysine N-methyltransferase MECOM isoform X8

      Conserved Domains (3) summary
      COG5048
      Location:289 → 641
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:600 → 620
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins

    5. XM_044251741.1 → XP_044107676.1  histone-lysine N-methyltransferase MECOM isoform X3

      Conserved Domains (4) summary
      PHA00733
      Location:846 → 965
      PHA00733; hypothetical protein
      COG5189
      Location:344 → 396
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:915 → 935
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins

    6. XM_044251739.1 → XP_044107674.1  histone-lysine N-methyltransferase MECOM isoform X1

      Conserved Domains (6) summary
      PHA00733
      Location:878 → 974
      PHA00733; hypothetical protein
      COG5189
      Location:344 → 396
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:924 → 944
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins
      pfam00096
      Location:922 → 944
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:936 → 960
      zf-H2C2_2; Zinc-finger double domain

    7. XM_044251747.1 → XP_044107682.1  histone-lysine N-methyltransferase MECOM isoform X7

      Conserved Domains (4) summary
      PHA00733
      Location:850 → 946
      PHA00733; hypothetical protein
      COG5189
      Location:316 → 368
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:896 → 916
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:19 → 176
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins

    8. XM_044251745.1 → XP_044107680.1  histone-lysine N-methyltransferase MECOM isoform X6

      Conserved Domains (5) summary
      PHA00733
      Location:690 → 786
      PHA00733; hypothetical protein
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:1 → 16
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:734 → 756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748 → 772
      zf-H2C2_2; Zinc-finger double domain

    9. XM_044251746.1 → XP_044107681.1  histone-lysine N-methyltransferase MECOM isoform X6

      Conserved Domains (5) summary
      PHA00733
      Location:690 → 786
      PHA00733; hypothetical protein
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:1 → 16
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:734 → 756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748 → 772
      zf-H2C2_2; Zinc-finger double domain

    10. XM_044251748.1 → XP_044107683.1  histone-lysine N-methyltransferase MECOM isoform X6

      Conserved Domains (5) summary
      PHA00733
      Location:690 → 786
      PHA00733; hypothetical protein
      sd00017
      Location:736 → 756
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cl40432
      Location:1 → 16
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
      pfam00096
      Location:734 → 756
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:748 → 772
      zf-H2C2_2; Zinc-finger double domain

    11. XM_044251743.1 → XP_044107678.1  histone-lysine N-methyltransferase MECOM isoform X5

      Conserved Domains (4) summary
      PHA00733
      Location:878 → 974
      PHA00733; hypothetical protein
      COG5189
      Location:344 → 396
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:924 → 944
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd19214
      Location:47 → 204
      PR-SET_PRDM3; PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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