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    PLEC plectin [ Vulpes lagopus (Arctic fox) ]

    Gene ID: 121498666, updated on 22-Mar-2024

    Summary

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    Gene symbol
    PLEC
    Gene description
    plectin
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Vulpes lagopus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Vulpes
    Orthologs
    human mouse all
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    Genomic context

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    See PLEC in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    100 current ASM1834538v1 (GCF_018345385.1) 9 NC_054832.1 (765790..821142)

    Chromosome 9 - NC_054832.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121498731 Neighboring gene spermatogenesis and centriole associated 1 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1 Neighboring gene epiplakin 1 Neighboring gene nuclear receptor binding protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_054832.1 Chromosome 9 Reference ASM1834538v1 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables keratin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intermediate filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plectin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Vulpes lagopus Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ASM1834538v1 Primary Assembly

    Genomic

    1. NC_054832.1 Reference ASM1834538v1 Primary Assembly

      Range
      765790..821142
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041768662.1 → XP_041624596.1  plectin isoform X3

      Conserved Domains (7) summary
      PTZ00121
      Location:1749 → 2493
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:550 → 644
      SPEC; Spectrin repeats
      smart00250
      Location:4337 → 4374
      PLEC; Plectin repeat
      COG5069
      Location:63 → 290
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:646 → 829
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1342 → 2072
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2356 → 2634
      DUF5401; Family of unknown function (DUF5401)

    2. XM_041768664.1 → XP_041624598.1  plectin isoform X4

      Conserved Domains (7) summary
      PTZ00121
      Location:1744 → 2488
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:545 → 639
      SPEC; Spectrin repeats
      smart00250
      Location:4332 → 4369
      PLEC; Plectin repeat
      COG5069
      Location:63 → 285
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:641 → 824
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1337 → 2067
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2351 → 2629
      DUF5401; Family of unknown function (DUF5401)

    3. XM_041768663.1 → XP_041624597.1  plectin isoform X3

      Conserved Domains (7) summary
      PTZ00121
      Location:1749 → 2493
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:550 → 644
      SPEC; Spectrin repeats
      smart00250
      Location:4337 → 4374
      PLEC; Plectin repeat
      COG5069
      Location:63 → 290
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:646 → 829
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1342 → 2072
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2356 → 2634
      DUF5401; Family of unknown function (DUF5401)

    4. XM_041768672.1 → XP_041624606.1  plectin isoform X11

      Conserved Domains (7) summary
      PTZ00121
      Location:1710 → 2454
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:511 → 605
      SPEC; Spectrin repeats
      smart00250
      Location:4298 → 4335
      PLEC; Plectin repeat
      COG5069
      Location:29 → 251
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:607 → 790
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1303 → 2033
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2317 → 2595
      DUF5401; Family of unknown function (DUF5401)

    5. XM_041768673.1 → XP_041624607.1  plectin isoform X12

      Conserved Domains (7) summary
      PTZ00121
      Location:1705 → 2449
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:506 → 600
      SPEC; Spectrin repeats
      smart00250
      Location:4293 → 4330
      PLEC; Plectin repeat
      COG5069
      Location:29 → 246
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:602 → 785
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1298 → 2028
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2312 → 2590
      DUF5401; Family of unknown function (DUF5401)

    6. XM_041768674.1 → XP_041624608.1  plectin isoform X13

      Conserved Domains (7) summary
      PTZ00121
      Location:1701 → 2445
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:502 → 596
      SPEC; Spectrin repeats
      smart00250
      Location:4289 → 4326
      PLEC; Plectin repeat
      COG5069
      Location:20 → 242
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:598 → 781
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1294 → 2024
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2308 → 2586
      DUF5401; Family of unknown function (DUF5401)

    7. XM_041768675.1 → XP_041624609.1  plectin isoform X14

      Conserved Domains (7) summary
      PTZ00121
      Location:1696 → 2440
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:497 → 591
      SPEC; Spectrin repeats
      smart00250
      Location:4284 → 4321
      PLEC; Plectin repeat
      COG5069
      Location:20 → 237
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:593 → 776
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1289 → 2019
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2303 → 2581
      DUF5401; Family of unknown function (DUF5401)

    8. XM_041768660.1 → XP_041624594.1  plectin isoform X1

      Conserved Domains (8) summary
      PTZ00121
      Location:1865 → 2609
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:666 → 760
      SPEC; Spectrin repeats
      smart00250
      Location:4453 → 4490
      PLEC; Plectin repeat
      COG5069
      Location:184 → 406
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:762 → 945
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1458 → 2188
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2472 → 2750
      DUF5401; Family of unknown function (DUF5401)
      cl02102
      Location:5 → 114
      S10_plectin; Plectin/S10 domain

    9. XM_041768661.1 → XP_041624595.1  plectin isoform X2

      Conserved Domains (8) summary
      PTZ00121
      Location:1860 → 2604
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:661 → 755
      SPEC; Spectrin repeats
      smart00250
      Location:4448 → 4485
      PLEC; Plectin repeat
      COG5069
      Location:184 → 401
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:757 → 940
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1453 → 2183
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2467 → 2745
      DUF5401; Family of unknown function (DUF5401)
      cl02102
      Location:5 → 114
      S10_plectin; Plectin/S10 domain

    10. XM_041768676.1 → XP_041624610.1  plectin isoform X15

      Conserved Domains (7) summary
      PTZ00121
      Location:1691 → 2435
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:492 → 586
      SPEC; Spectrin repeats
      smart00250
      Location:4279 → 4316
      PLEC; Plectin repeat
      COG5069
      Location:10 → 232
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:588 → 771
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1284 → 2014
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2298 → 2576
      DUF5401; Family of unknown function (DUF5401)

    11. XM_041768677.1 → XP_041624611.1  plectin isoform X16

      Conserved Domains (7) summary
      PTZ00121
      Location:1686 → 2430
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:487 → 581
      SPEC; Spectrin repeats
      smart00250
      Location:4274 → 4311
      PLEC; Plectin repeat
      COG5069
      Location:10 → 227
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:583 → 766
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1279 → 2009
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2293 → 2571
      DUF5401; Family of unknown function (DUF5401)

    12. XM_041768668.1 → XP_041624602.1  plectin isoform X7

      Conserved Domains (7) summary
      PTZ00121
      Location:1723 → 2467
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:524 → 618
      SPEC; Spectrin repeats
      smart00250
      Location:4311 → 4348
      PLEC; Plectin repeat
      COG5069
      Location:42 → 264
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:620 → 803
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1316 → 2046
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2330 → 2608
      DUF5401; Family of unknown function (DUF5401)

    13. XM_041768671.1 → XP_041624605.1  plectin isoform X10

      Conserved Domains (7) summary
      PTZ00121
      Location:1718 → 2462
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:519 → 613
      SPEC; Spectrin repeats
      smart00250
      Location:4306 → 4343
      PLEC; Plectin repeat
      COG5069
      Location:42 → 259
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:615 → 798
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1311 → 2041
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2325 → 2603
      DUF5401; Family of unknown function (DUF5401)

    14. XM_041768666.1 → XP_041624600.1  plectin isoform X5

      Conserved Domains (7) summary
      PTZ00121
      Location:1731 → 2475
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:532 → 626
      SPEC; Spectrin repeats
      smart00250
      Location:4319 → 4356
      PLEC; Plectin repeat
      COG5069
      Location:45 → 272
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:628 → 811
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1324 → 2054
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2338 → 2616
      DUF5401; Family of unknown function (DUF5401)

    15. XM_041768667.1 → XP_041624601.1  plectin isoform X6

      Conserved Domains (7) summary
      PTZ00121
      Location:1726 → 2470
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:527 → 621
      SPEC; Spectrin repeats
      smart00250
      Location:4314 → 4351
      PLEC; Plectin repeat
      COG5069
      Location:45 → 267
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:623 → 806
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1319 → 2049
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2333 → 2611
      DUF5401; Family of unknown function (DUF5401)

    16. XM_041768669.1 → XP_041624603.1  plectin isoform X8

      Conserved Domains (7) summary
      PTZ00121
      Location:1723 → 2467
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:524 → 618
      SPEC; Spectrin repeats
      smart00250
      Location:4311 → 4348
      PLEC; Plectin repeat
      COG5069
      Location:42 → 264
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:620 → 803
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1316 → 2046
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2330 → 2608
      DUF5401; Family of unknown function (DUF5401)

    17. XM_041768670.1 → XP_041624604.1  plectin isoform X9

      Conserved Domains (7) summary
      PTZ00121
      Location:1718 → 2462
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:519 → 613
      SPEC; Spectrin repeats
      smart00250
      Location:4306 → 4343
      PLEC; Plectin repeat
      COG5069
      Location:42 → 259
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:615 → 798
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1311 → 2041
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2325 → 2603
      DUF5401; Family of unknown function (DUF5401)

    18. XM_041768678.1 → XP_041624612.1  plectin isoform X17

      Conserved Domains (7) summary
      PTZ00121
      Location:1624 → 2368
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:425 → 519
      SPEC; Spectrin repeats
      smart00250
      Location:4212 → 4249
      PLEC; Plectin repeat
      COG5069
      Location:1 → 165
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00176
      Location:521 → 704
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:1217 → 1947
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam17380
      Location:2231 → 2509
      DUF5401; Family of unknown function (DUF5401)
    Nucleotide Protein Strain
    Heading Accession and Version

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