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    CBLB Cbl proto-oncogene B [ Gallus gallus (chicken) ]

    Gene ID: 418406, updated on 17-Aug-2024

    Summary

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    Symbol
    CBLBprovided by CGNC
    Full Name
    Cbl proto-oncogene Bprovided by CGNC
    Primary source
    CGNC:11434
    See related
    Ensembl:ENSGALG00010005166
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See CBLB in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (86890885..87014636, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (86941229..87064811, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107753 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC101751371 Neighboring gene uncharacterized LOC112530378 Neighboring gene BBX, HMG-box containing

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence b
    Cbl proto-oncogene B, E3 ubiquitin protein ligase
    Cbl proto-oncogene, E3 ubiquitin protein ligase B
    XP_004938335.1
    XP_040514069.1
    XP_040514070.1
    XP_040514071.1
    XP_040514072.1
    XP_040561305.1
    XP_040561307.1
    XP_416621.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      86890885..87014636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004938278.5 → XP_004938335.1  E3 ubiquitin-protein ligase CBL-B isoform X2

      UniProtKB/TrEMBL
      A0A8V0XF80
      Related
      ENSGALP00010006794.1, ENSGALT00010012182.1
      Conserved Domains (6) summary
      cd09920
      Location:293 → 389
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:400 → 578
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:929 → 969
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:399 → 464
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:89 → 209
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:216 → 299
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    2. XM_416621.8 → XP_416621.3  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      F1NL77
      Related
      ENSGALP00010006793.1, ENSGALT00010012180.1
      Conserved Domains (6) summary
      cd09920
      Location:293 → 389
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:400 → 578
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:973 → 1013
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:399 → 464
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:89 → 209
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:216 → 299
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    3. XM_040705373.2 → XP_040561307.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      Conserved Domains (4) summary
      cd09920
      Location:241 → 337
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:348 → 526
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:921 → 961
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:347 → 412
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

    4. XM_040705371.2 → XP_040561305.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      Conserved Domains (4) summary
      cd09920
      Location:241 → 337
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:348 → 526
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:921 → 961
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:347 → 412
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      86941229..87064811 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040658136.2 → XP_040514070.1  E3 ubiquitin-protein ligase CBL-B isoform X2

      UniProtKB/TrEMBL
      A0A8V0XF80
      Conserved Domains (6) summary
      cd09920
      Location:293 → 389
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:400 → 578
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:929 → 969
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:399 → 464
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:89 → 209
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:216 → 299
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    2. XM_040658135.2 → XP_040514069.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/TrEMBL
      F1NL77
      Conserved Domains (6) summary
      cd09920
      Location:293 → 389
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:400 → 578
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:973 → 1013
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:399 → 464
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:89 → 209
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:216 → 299
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    3. XM_040658138.2 → XP_040514072.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      Conserved Domains (4) summary
      cd09920
      Location:241 → 337
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:348 → 526
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:921 → 961
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:347 → 412
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

    4. XM_040658137.2 → XP_040514071.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      Conserved Domains (4) summary
      cd09920
      Location:241 → 337
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      COG5243
      Location:348 → 526
      HRD1; HRD ubiquitin ligase complex, ER membrane component [Posttranslational modification, protein turnover, chaperones]
      cd14392
      Location:921 → 961
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:347 → 412
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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