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    MCF2L MCF.2 cell line derived transforming sequence like [ Gallus gallus (chicken) ]

    Gene ID: 418748, updated on 10-Oct-2024

    Summary

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    Symbol
    MCF2Lprovided by CGNC
    Full Name
    MCF.2 cell line derived transforming sequence likeprovided by CGNC
    Primary source
    CGNC:12632
    See related
    Ensembl:ENSGALG00010014903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See MCF2L in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (137620567..137768881, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (137619880..137768229, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene coagulation factor X Neighboring gene coagulation factor VII Neighboring gene ATPase phospholipid transporting 11A Neighboring gene tubulin gamma complex associated protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extrinsic component of membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide exchange factor DBS

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001397798.1 → NP_001384727.1  guanine nucleotide exchange factor DBS isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000025
      Related
      ENSGALP00010020870.1, ENSGALT00010035951.1

    2. NM_001397799.1 → NP_001384728.1  guanine nucleotide exchange factor DBS isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000025
      UniProtKB/TrEMBL
      A0A8V0YQC5
      Related
      ENSGALP00010020868.1, ENSGALT00010035949.1

    3. NM_001397800.1 → NP_001384729.1  guanine nucleotide exchange factor DBS isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000025

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      137620567..137768881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015277843.4 → XP_015133329.2  guanine nucleotide exchange factor DBS isoform X5

      UniProtKB/TrEMBL
      A0A8V0YQD5, A0A8V0YS34
      Related
      ENSGALP00010020874.1, ENSGALT00010035964.1
      Conserved Domains (5) summary
      cd11857
      Location:1110 → 1164
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:79 → 224
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:635 → 812
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:359 → 557
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:819 → 950
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    2. XM_040699285.2 → XP_040555219.1  guanine nucleotide exchange factor DBS isoform X10

      UniProtKB/TrEMBL
      A0A8V0YQE0
      Conserved Domains (5) summary
      cd11857
      Location:1073 → 1127
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:87 → 232
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:643 → 820
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:367 → 565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:827 → 958
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    3. XM_040699251.2 → XP_040555185.1  guanine nucleotide exchange factor DBS isoform X3

      UniProtKB/TrEMBL
      A0A8V0YQD5
      Conserved Domains (5) summary
      cd11857
      Location:1118 → 1172
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:87 → 232
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:643 → 820
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:367 → 565
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:827 → 958
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    4. XM_040699276.2 → XP_040555210.1  guanine nucleotide exchange factor DBS isoform X8

      UniProtKB/TrEMBL
      A0A8V0YQC1
      Related
      ENSGALP00010020863.1, ENSGALT00010035944.1
      Conserved Domains (5) summary
      cd11857
      Location:1077 → 1131
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:46 → 191
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:602 → 779
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:326 → 524
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:786 → 917
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    5. XM_046941155.1 → XP_046797111.1  guanine nucleotide exchange factor DBS isoform X12

    6. XM_040699270.2 → XP_040555204.1  guanine nucleotide exchange factor DBS isoform X7

      UniProtKB/TrEMBL
      A0A8V0YIX5
      Related
      ENSGALP00010020861.1, ENSGALT00010035942.1
      Conserved Domains (5) summary
      cd11857
      Location:1091 → 1145
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:60 → 205
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:616 → 793
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:340 → 538
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:800 → 931
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    7. XM_040699263.1 → XP_040555197.1  guanine nucleotide exchange factor DBS isoform X6

      UniProtKB/TrEMBL
      A0A8V0YQC1
      Conserved Domains (5) summary
      cd11857
      Location:1036 → 1090
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:50 → 195
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:606 → 783
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:330 → 528
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:790 → 921
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    8. XM_040699242.2 → XP_040555176.1  guanine nucleotide exchange factor DBS isoform X2

      UniProtKB/TrEMBL
      A0A8V0YQC1
      Related
      ENSGALP00010020857.1, ENSGALT00010035938.1
      Conserved Domains (5) summary
      cd11857
      Location:1061 → 1115
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:50 → 195
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:606 → 783
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:330 → 528
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:790 → 921
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    9. XM_040699256.2 → XP_040555190.1  guanine nucleotide exchange factor DBS isoform X4

      UniProtKB/TrEMBL
      A0A8V0YQC1
      Conserved Domains (5) summary
      cd11857
      Location:1056 → 1110
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:50 → 195
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:606 → 783
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:330 → 528
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:790 → 921
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    10. XM_040699234.2 → XP_040555168.1  guanine nucleotide exchange factor DBS isoform X1

      UniProtKB/TrEMBL
      A0A8V0YQC1
      Conserved Domains (5) summary
      cd11857
      Location:1081 → 1135
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:50 → 195
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:606 → 783
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:330 → 528
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:790 → 921
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    11. XM_040699294.2 → XP_040555228.1  guanine nucleotide exchange factor DBS isoform X12

      UniProtKB/TrEMBL
      A0A8V0YQC0
      Conserved Domains (5) summary
      cd11857
      Location:1048 → 1102
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:17 → 162
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:573 → 750
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:297 → 495
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:757 → 888
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    12. XM_040699281.2 → XP_040555215.1  guanine nucleotide exchange factor DBS isoform X9

      UniProtKB/TrEMBL
      A0A8V0YQC0
      Related
      ENSGALP00010020855.1, ENSGALT00010035936.1
      Conserved Domains (5) summary
      cd11857
      Location:1075 → 1129
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:44 → 189
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:600 → 777
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:324 → 522
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:784 → 915
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    13. XM_040699288.2 → XP_040555222.1  guanine nucleotide exchange factor DBS isoform X11

      UniProtKB/TrEMBL
      A0A8V0YQC0
      Conserved Domains (5) summary
      cd11857
      Location:1058 → 1112
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      smart00516
      Location:27 → 172
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00160
      Location:583 → 760
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:307 → 505
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:767 → 898
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    14. XM_046941160.1 → XP_046797116.1  guanine nucleotide exchange factor DBS isoform X13

    15. XM_040699299.2 → XP_040555233.1  guanine nucleotide exchange factor DBS isoform X13

      UniProtKB/TrEMBL
      A0A8V0YQC0
      Conserved Domains (4) summary
      cd11857
      Location:918 → 972
      SH3_DBS; Src homology 3 domain of DBL's Big Sister (DBS), a guanine nucleotide exchange factor
      cd00160
      Location:443 → 620
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd00176
      Location:167 → 365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd01227
      Location:627 → 758
      PH_Dbs; DBL's big sister protein pleckstrin homology (PH) domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      137619880..137768229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046908095.1 → XP_046764051.1  guanine nucleotide exchange factor DBS isoform X5

    2. XM_046908100.1 → XP_046764056.1  guanine nucleotide exchange factor DBS isoform X10

    3. XM_046908093.1 → XP_046764049.1  guanine nucleotide exchange factor DBS isoform X3

    4. XM_046908098.1 → XP_046764054.1  guanine nucleotide exchange factor DBS isoform X8

    5. XM_046908103.1 → XP_046764059.1  guanine nucleotide exchange factor DBS isoform X12

    6. XM_046908097.1 → XP_046764053.1  guanine nucleotide exchange factor DBS isoform X7

    7. XM_046908096.1 → XP_046764052.1  guanine nucleotide exchange factor DBS isoform X6

    8. XM_046908092.1 → XP_046764048.1  guanine nucleotide exchange factor DBS isoform X2

    9. XM_046908094.1 → XP_046764050.1  guanine nucleotide exchange factor DBS isoform X4

    10. XM_046908091.1 → XP_046764047.1  guanine nucleotide exchange factor DBS isoform X1

    11. XM_046908102.1 → XP_046764058.1  guanine nucleotide exchange factor DBS isoform X12

    12. XM_046908099.1 → XP_046764055.1  guanine nucleotide exchange factor DBS isoform X9

    13. XM_046908101.1 → XP_046764057.1  guanine nucleotide exchange factor DBS isoform X11

    14. XM_046908105.1 → XP_046764061.1  guanine nucleotide exchange factor DBS isoform X13

    15. XM_046908104.1 → XP_046764060.1  guanine nucleotide exchange factor DBS isoform X13

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001252063.1: Suppressed sequence

      Description
      NM_001252063.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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