TLR2 toll like receptor 2 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TLR2provided by VGNC
Official Full Name: toll like receptor 2provided by VGNC
Primary source: VGNC:VGNC:49982
See related: BGD:BT11801; Ensembl:ENSBTAG00000008008
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	17	NC_037344.1 (3939778..3979483, complement)

Chromosome 17 - NC_037344.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037344.1 Chromosome 17 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Toll-like Receptor 2 Is Associated with the Immune Response, Apoptosis, and Angiogenesis in the Mammary Glands of Dairy Cows with Clinical Mastitis.
Title: Toll-like Receptor 2 Is Associated with the Immune Response, Apoptosis, and Angiogenesis in the Mammary Glands of Dairy Cows with Clinical Mastitis.
Lipopolysaccharide (LPS) exposure causes an acute increase in TLR2 gene expression in cultured primary ruminal epithelial cells
Title: Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells.
Expression in rumen papillae decreases in response to subacute acidosis
Title: Potential for a localized immune response by the ruminal epithelium in nonpregnant heifers following a short-term subacute ruminal acidosis challenge.
Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality.
Title: Single Nucleotide Polymorphisms in the Bovine TLR2 Extracellular Domain Contribute to Breed and Species-Specific Innate Immune Functionality.
Toll-like receptor 2 mediates the immune response of the bovine oviductal ampulla to sperm binding.
Title: Toll-like receptor 2 mediates the immune response of the bovine oviductal ampulla to sperm binding.
Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
Title: Toll-like receptors and high mobility group box 1 in granulosa cells during bovine follicle maturation.
Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
Title: Association of TLR gene variants in a Czech Red Pied cattle population with reproductive traits.
SNPs rs8193046 and rs8193060 are likely a potential marker against Mycobacterium avium subspecies paratuberculosis and a selection programme eliminating AG genotype for rs8193046 and CT genotype for rs8193060 might be beneficial in conferring resistance to Mycobacterium avium subspecies paratuberculosis in Indian cattle population
Title: Genetic association of polymorphisms in bovine TLR2 and TLR4 genes with Mycobacterium avium subspecies paratuberculosis infection in Indian cattle population.
results suggest that polymorphisms in the TLR2 gene might not play a significant role in the BTB risk in Chinese Holstein cattle
Title: Toll-like receptor 2 gene polymorphisms in Chinese Holstein cattle and their associations with bovine tuberculosis.
Transcription levels of TLR2, TLR4, and CD14 in Holstein cows with retained placenta significantly decreased between the first and the seventh day postpartum.
Title: Changes in endometrial transcription of TLR2, TLR4, and CD14 during the first-week postpartum in dairy cows with retained placenta.

Submit: New GeneRIF Correction See all GeneRIFs (29)

General gene information

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Markers

TLR2 (e-PCR)
- UniSTS:277943

AF368419 (e-PCR)
- UniSTS:277943

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables triacyl lipopeptide binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 2

Names: Toll-like receptor; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a; toll-like-receptor 2, exon 1a_

NP_776622.1

EC 3.2.2.6

XP_005217503.1

EC 3.2.2.6

XP_005217504.1

EC 3.2.2.6

XP_015330814.1

EC 3.2.2.6

XP_015330815.1

EC 3.2.2.6

XP_059731854.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_174197.2 → NP_776622.1 toll-like receptor 2 precursor

See identical proteins and their annotated locations for NP_776622.1

Status: PROVISIONAL

Source sequence(s)

AF368419

UniProtKB/Swiss-Prot

B5T265, B5T266, B5T271, Q6GV20, Q95LA9, Q9GL66

UniProtKB/TrEMBL

A0A0P0QLR2, F1N720

Related

ENSBTAP00000077629.1, ENSBTAT00000087841.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

cd00116
Location:16 → 186

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:459 → 494

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037344.1 Reference ARS-UCD2.0 Primary Assembly

Range

3939778..3979483 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_059875871.1 → XP_059731854.1 toll-like receptor 2 isoform X2

UniProtKB/TrEMBL

A0AAA9TTS2
XM_015475329.3 → XP_015330815.1 toll-like receptor 2 isoform X2

UniProtKB/TrEMBL

A0AAA9TTS2, F1N720

Related

ENSBTAP00000077804.1, ENSBTAT00000108671.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

cd00116
Location:16 → 186

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:459 → 494

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat
XM_015475328.3 → XP_015330814.1 toll-like receptor 2 isoform X1

UniProtKB/TrEMBL

F1N720

Conserved Domains (6) summary

smart00082
Location:543 → 596

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:650 → 794

TIR; Toll - interleukin 1 - resistance

cd00116
Location:26 → 196

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:67 → 87

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:467 → 504

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:87 → 145

LRR_8; Leucine rich repeat
XM_005217447.5 → XP_005217504.1 toll-like receptor 2 isoform X2

See identical proteins and their annotated locations for XP_005217504.1

UniProtKB/TrEMBL

A0AAA9TTS2, F1N720

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

cd00116
Location:16 → 186

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:459 → 494

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat
XM_005217446.5 → XP_005217503.1 toll-like receptor 2 isoform X2

See identical proteins and their annotated locations for XP_005217503.1

UniProtKB/TrEMBL

A0AAA9TTS2, F1N720

Related

ENSBTAP00000100031.1, ENSBTAT00000132994.1

Conserved Domains (6) summary

smart00082
Location:533 → 586

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

cd00116
Location:16 → 186

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:57 → 77

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:459 → 494

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat