U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Dolk dolichol kinase [ Mus musculus (house mouse) ]

    Gene ID: 227697, updated on 28-Oct-2024

    Summary

    Official Symbol
    Dolkprovided by MGI
    Official Full Name
    dolichol kinaseprovided by MGI
    Primary source
    MGI:MGI:2677836
    See related
    Ensembl:ENSMUSG00000075419 AllianceGenome:MGI:2677836
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmem15; mKIAA1094
    Summary
    Predicted to enable dolichol kinase activity. Predicted to be involved in dolichyl monophosphate biosynthetic process and protein mannosylation. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Im. Orthologous to human DOLK (dolichol kinase). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dolk in Genome Data Viewer
    Location:
    2 B; 2 21.49 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30174241..30176366, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30284229..30286354, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7804 Neighboring gene STARR-seq mESC enhancer starr_04091 Neighboring gene leucine rich repeat containing 8A VRAC subunit A Neighboring gene phytanoyl-CoA dioxygenase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E7805 Neighboring gene nucleoporin 188 Neighboring gene predicted gene, 39780 Neighboring gene SH3-domain GRB2-like endophilin B2

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC36683

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dolichol kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables dolichol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in dolichyl monophosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dolichyl monophosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dolichyl monophosphate biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein mannosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dolichol kinase
    Names
    transmembrane protein 15
    NP_808316.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177648.3NP_808316.1  dolichol kinase

      See identical proteins and their annotated locations for NP_808316.1

      Status: VALIDATED

      Source sequence(s)
      AL954388
      Consensus CDS
      CCDS15877.1
      UniProtKB/Swiss-Prot
      Q8R2Y3
      Related
      ENSMUSP00000097792.4, ENSMUST00000100219.5
      Conserved Domains (1) summary
      cl21502
      Location:331520
      CTP_transf_1; Cytidylyltransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30174241..30176366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)