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    Layn layilin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500996, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Laynprovided by RGD
    Official Full Name
    layilinprovided by RGD
    Primary source
    RGD:1564444
    See related
    EnsemblRapid:ENSRNOG00000011228 AllianceGenome:RGD:1564444
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564444
    Summary
    Predicted to enable hyaluronic acid binding activity. Predicted to be located in membrane. Orthologous to human LAYN (layilin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 32.4), Lung (RPKM 17.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Layn in Genome Data Viewer
    Location:
    8q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (60261325..60280797, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (51363928..51384748, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (55447203..55469420, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene salt-inducible kinase 2 Neighboring gene transfer RNA proline (anticodon AGG) 89 Neighboring gene uncharacterized LOC120094336 Neighboring gene U4 spliceosomal RNA Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene microRNA 34c Neighboring gene microRNA 34b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Bono P, et al. Mol Biol Cell, 2001 Apr. PMID 11294894, Free PMC Article
    2. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables hyaluronic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hyaluronic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    layilin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191997.1 → NP_001178926.1  layilin precursor

      See identical proteins and their annotated locations for NP_001178926.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J4G7
      Related
      ENSRNOP00000050686.6, ENSRNOT00000040162.6
      Conserved Domains (2) summary
      pfam15102
      Location:190 → 324
      TMEM154; TMEM154 protein family
      cl02432
      Location:37 → 185
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      60261325..60280797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766328.4 → XP_008764550.1  layilin isoform X2

      UniProtKB/TrEMBL
      A0A0G2K085, A6J4G7
      Related
      ENSRNOP00000104639.1, ENSRNOT00000165306.1
      Conserved Domains (1) summary
      cl02432
      Location:30 → 178
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    2. XM_039081959.2 → XP_038937887.1  layilin isoform X5

      UniProtKB/TrEMBL
      A6J4G7
      Conserved Domains (1) summary
      cl02432
      Location:30 → 178
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    3. XM_039081958.2 → XP_038937886.1  layilin isoform X4

      UniProtKB/TrEMBL
      A6J4G7
      Conserved Domains (1) summary
      cl02432
      Location:30 → 178
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    4. XM_063265987.1 → XP_063122057.1  layilin isoform X3

      Related
      ENSRNOP00000071344.2, ENSRNOT00000088607.3

    5. XM_006243049.5 → XP_006243111.1  layilin isoform X1

      UniProtKB/TrEMBL
      A6J4G7, D3Z895
      Related
      ENSRNOP00000112146.1, ENSRNOT00000156939.1
      Conserved Domains (2) summary
      pfam15102
      Location:183 → 317
      TMEM154; TMEM154 protein family
      cl02432
      Location:30 → 178
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    6. XM_006243052.5 → XP_006243114.1  layilin isoform X6

      Conserved Domains (1) summary
      pfam15102
      Location:113 → 247
      TMEM154; TMEM154 protein family

    RNA

    1. XR_010054013.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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