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    Hoxb6 homeo box B6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497986, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Hoxb6provided by RGD
    Official Full Name
    homeo box B6provided by RGD
    Primary source
    RGD:1562142
    See related
    AllianceGenome:RGD:1562142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562142
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anterior/posterior pattern specification and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within embryonic skeletal system morphogenesis and erythrocyte homeostasis. Predicted to be active in nucleus. Orthologous to human HOXB6 (homeobox B6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 132.4), Kidney (RPKM 129.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hoxb6 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (81755263..81763999)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (81258726..81267458)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (84147331..84150238)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene homeo box B8 Neighboring gene homeo box B7 Neighboring gene homeobox B5 and homeobox B6, opposite strand Neighboring gene homeo box B5 Neighboring gene microRNA 10a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Disruption of the homeobox gene Hoxb-6 in mice results in increased numbers of early erythrocyte progenitors. Kappen C. Am J Hematol, 2000 Oct. PMID 10996827
    2. Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Rancourt DE, et al. Genes Dev, 1995 Jan 1. PMID 7828847
    3. Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein. Iimura T, et al. Biochem Biophys Res Commun, 1994 Jun 15. PMID 7911662
    4. A large targeted deletion of Hoxb1-Hoxb9 produces a series of single-segment anterior homeotic transformations. Medina-Martínez O, et al. Dev Biol, 2000 Jun 1. PMID 10885747
    5. Hox patterning of the vertebrate rib cage. McIntyre DC, et al. Development, 2007 Aug. PMID 17626057

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within anterior/posterior pattern specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within embryonic skeletal system morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within erythrocyte homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein Hox-B6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398852.1 → NP_001385781.1  homeobox protein Hox-B6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HIE5, D3ZLU8
      Conserved Domains (1) summary
      pfam00046
      Location:150 → 203
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      81755263..81763999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087720.2 → XP_038943648.1  homeobox protein Hox-B6 isoform X1

      UniProtKB/TrEMBL
      A6HIE5, D3ZLU8
      Conserved Domains (1) summary
      pfam00046
      Location:150 → 203
      Homeobox; Homeobox domain
    Nucleotide Protein Strain
    Heading Accession and Version

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