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    CUL4B cullin 4B [ Canis lupus familiaris (dog) ]

    Gene ID: 492102, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CUL4Bprovided by VGNC
    Official Full Name
    cullin 4Bprovided by VGNC
    Primary source
    VGNC:VGNC:39732
    See related
    Ensembl:ENSCAFG00845022607
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Orthologs
    human mouse all
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    Genomic context

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    See CUL4B in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (94236531..94284539, complement)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (78521518..78569760, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (93223172..93271175, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (91685541..91733782, complement)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (93448317..93496329, complement)

    Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119868232 Neighboring gene eukaryotic translation initiation factor 4E type 2-like Neighboring gene U6 spliceosomal RNA Neighboring gene 40S ribosomal protein S2-like Neighboring gene uncharacterized LOC111094921 Neighboring gene MCTS1 re-initiation and release factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4B-RING E3 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cullin-4B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051843.1 Reference ROS_Cfam_1.0

      Range
      94236531..94284539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038450780.1 → XP_038306708.1  cullin-4B isoform X3

      UniProtKB/TrEMBL
      A0A8I3PD29
      Conserved Domains (2) summary
      smart00884
      Location:913 → 978
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:286 → 885
      Cullin; Cullin family

    2. XM_038450782.1 → XP_038306710.1  cullin-4B isoform X5

      UniProtKB/TrEMBL
      A0A8I3PV51
      Conserved Domains (2) summary
      smart00884
      Location:842 → 907
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:215 → 814
      Cullin; Cullin family

    3. XM_038450777.1 → XP_038306705.1  cullin-4B isoform X1

      UniProtKB/TrEMBL
      A0A8I3PD29
      Conserved Domains (2) summary
      smart00884
      Location:950 → 1015
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 922
      Cullin; Cullin family

    4. XM_038450781.1 → XP_038306709.1  cullin-4B isoform X4

      UniProtKB/TrEMBL
      A0A8I3PV51
      Related
      ENSCAFP00845032189.1, ENSCAFT00845041077.1
      Conserved Domains (2) summary
      smart00884
      Location:879 → 944
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:252 → 851
      Cullin; Cullin family

    5. XM_038450778.1 → XP_038306706.1  cullin-4B isoform X2

      UniProtKB/TrEMBL
      A0A8I3PD29, A0A8I3PE50
      Related
      ENSCAFP00845032038.1, ENSCAFT00845040909.1
      Conserved Domains (2) summary
      smart00884
      Location:948 → 1013
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 920
      Cullin; Cullin family

    6. XM_038450784.1 → XP_038306712.1  cullin-4B isoform X7

      UniProtKB/TrEMBL
      A0A8I3PI16, A0A8I3PSQ6
      Related
      ENSCAFP00845032281.1, ENSCAFT00845041189.1
      Conserved Domains (2) summary
      smart00884
      Location:829 → 894
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 801
      Cullin; Cullin family

    7. XM_038450783.1 → XP_038306711.1  cullin-4B isoform X6

      UniProtKB/TrEMBL
      A0A8I3PSQ6
      Conserved Domains (2) summary
      smart00884
      Location:831 → 896
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 803
      Cullin; Cullin family

    8. XM_038450785.1 → XP_038306713.1  cullin-4B isoform X8

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8I3PSQ6, A0A8I3S3A7, A0A8P0PQ22, A0A8P0TU95
      Related
      ENSCAFP00845031490.1, ENSCAFT00845040205.1
      Conserved Domains (2) summary
      smart00884
      Location:646 → 711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 618
      Cullin; Cullin family

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049299.1 Alternate UMICH_Zoey_3.1

      Range
      91685541..91733782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038524247.1 → XP_038380175.1  cullin-4B isoform X3

    2. XM_038524249.1 → XP_038380177.1  cullin-4B isoform X5

    3. XM_038524245.1 → XP_038380173.1  cullin-4B isoform X1

      Conserved Domains (2) summary
      smart00884
      Location:950 → 1015
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 922
      Cullin; Cullin family

    4. XM_038524248.1 → XP_038380176.1  cullin-4B isoform X4

      Conserved Domains (2) summary
      smart00884
      Location:879 → 944
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:252 → 851
      Cullin; Cullin family

    5. XM_038524246.1 → XP_038380174.1  cullin-4B isoform X2

      Conserved Domains (2) summary
      smart00884
      Location:948 → 1013
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 920
      Cullin; Cullin family

    6. XM_038524251.1 → XP_038380179.1  cullin-4B isoform X7

      Conserved Domains (2) summary
      smart00884
      Location:829 → 894
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 801
      Cullin; Cullin family

    7. XM_038524250.1 → XP_038380178.1  cullin-4B isoform X6

      Conserved Domains (2) summary
      smart00884
      Location:831 → 896
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 803
      Cullin; Cullin family

    8. XM_038524252.1 → XP_038380180.1  cullin-4B isoform X8

      Conserved Domains (2) summary
      smart00884
      Location:646 → 711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 618
      Cullin; Cullin family

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

      Range
      93448317..93496329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038652736.1 → XP_038508664.1  cullin-4B isoform X3

    2. XM_038652738.1 → XP_038508666.1  cullin-4B isoform X5

    3. XM_038652734.1 → XP_038508662.1  cullin-4B isoform X1

      Conserved Domains (2) summary
      smart00884
      Location:950 → 1015
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 922
      Cullin; Cullin family

    4. XM_038652737.1 → XP_038508665.1  cullin-4B isoform X4

      Conserved Domains (2) summary
      smart00884
      Location:879 → 944
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:252 → 851
      Cullin; Cullin family

    5. XM_038652735.1 → XP_038508663.1  cullin-4B isoform X2

      Conserved Domains (2) summary
      smart00884
      Location:948 → 1013
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 920
      Cullin; Cullin family

    6. XM_038652740.1 → XP_038508668.1  cullin-4B isoform X7

      Conserved Domains (2) summary
      smart00884
      Location:829 → 894
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 801
      Cullin; Cullin family

    7. XM_038652739.1 → XP_038508667.1  cullin-4B isoform X6

      Conserved Domains (2) summary
      smart00884
      Location:831 → 896
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 803
      Cullin; Cullin family

    8. XM_038652741.1 → XP_038508669.1  cullin-4B isoform X8

      Conserved Domains (2) summary
      smart00884
      Location:646 → 711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 618
      Cullin; Cullin family

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

      Range
      93223172..93271175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_038588217.1 → XP_038444145.1  cullin-4B isoform X3

      UniProtKB/TrEMBL
      A0A8I3PD29

    2. XM_038588219.1 → XP_038444147.1  cullin-4B isoform X5

      UniProtKB/TrEMBL
      A0A8C0P7B0, A0A8P0NUY9

    3. XM_038588215.1 → XP_038444143.1  cullin-4B isoform X1

      UniProtKB/TrEMBL
      A0A8I3PD29
      Conserved Domains (2) summary
      smart00884
      Location:950 → 1015
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 922
      Cullin; Cullin family

    4. XM_038588218.1 → XP_038444146.1  cullin-4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0P7B0, A0A8P0NUY9
      Conserved Domains (2) summary
      smart00884
      Location:879 → 944
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:252 → 851
      Cullin; Cullin family

    5. XM_038588216.1 → XP_038444144.1  cullin-4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0PB39, A0A8I3PD29, A0A8P0P312
      Conserved Domains (2) summary
      smart00884
      Location:948 → 1013
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 920
      Cullin; Cullin family

    6. XM_038588221.1 → XP_038444149.1  cullin-4B isoform X7

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8C0JRZ3, A0A8C0P7H0, A0A8P0PE73, A0A8P0TU95
      Conserved Domains (2) summary
      smart00884
      Location:829 → 894
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 801
      Cullin; Cullin family

    7. XM_038588220.1 → XP_038444148.1  cullin-4B isoform X6

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8P0TU95
      Conserved Domains (2) summary
      smart00884
      Location:831 → 896
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 803
      Cullin; Cullin family

    8. XM_038588222.1 → XP_038444150.1  cullin-4B isoform X8

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8I3PSQ6, A0A8I3S3A7, A0A8P0PQ22, A0A8P0TU95
      Conserved Domains (2) summary
      smart00884
      Location:646 → 711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 618
      Cullin; Cullin family

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      78521518..78569760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_014111725.3 → XP_013967200.2  cullin-4B isoform X3

      UniProtKB/TrEMBL
      A0A8I3PD29
      Conserved Domains (2) summary
      smart00884
      Location:913 → 978
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:287 → 884
      Cullin; Cullin family

    2. XM_022415630.2 → XP_022271338.1  cullin-4B isoform X5

      UniProtKB/TrEMBL
      A0A8C0P7B0, A0A8P0NUY9
      Conserved Domains (2) summary
      smart00884
      Location:842 → 907
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:216 → 813
      Cullin; Cullin family

    3. XM_038464390.1 → XP_038320318.1  cullin-4B isoform X1

      UniProtKB/TrEMBL
      A0A8I3PD29
      Conserved Domains (2) summary
      smart00884
      Location:950 → 1015
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 922
      Cullin; Cullin family

    4. XM_038464391.1 → XP_038320319.1  cullin-4B isoform X4

      UniProtKB/TrEMBL
      A0A8C0P7B0, A0A8P0NUY9
      Conserved Domains (2) summary
      smart00884
      Location:879 → 944
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:252 → 851
      Cullin; Cullin family

    5. XM_859535.7 → XP_864628.5  cullin-4B isoform X2

      UniProtKB/TrEMBL
      A0A8C0PB39, A0A8I3PD29, A0A8P0P312
      Conserved Domains (2) summary
      smart00884
      Location:948 → 1013
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:323 → 920
      Cullin; Cullin family

    6. XM_014111727.3 → XP_013967202.1  cullin-4B isoform X7

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8C0JRZ3, A0A8C0P7H0, A0A8P0PE73, A0A8P0TU95
      Conserved Domains (2) summary
      smart00884
      Location:829 → 894
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 801
      Cullin; Cullin family

    7. XM_014111726.3 → XP_013967201.1  cullin-4B isoform X6

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8P0TU95
      Conserved Domains (2) summary
      smart00884
      Location:831 → 896
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:204 → 803
      Cullin; Cullin family

    8. XM_038464392.1 → XP_038320320.1  cullin-4B isoform X8

      UniProtKB/TrEMBL
      A0A8C0JRJ4, A0A8I3PSQ6, A0A8I3S3A7, A0A8P0PQ22, A0A8P0TU95
      Conserved Domains (2) summary
      smart00884
      Location:646 → 711
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:21 → 618
      Cullin; Cullin family
    Nucleotide Protein
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