U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Sf3b3 splicing factor 3b, subunit 3 [ Mus musculus (house mouse) ]

    Gene ID: 101943, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sf3b3provided by MGI
    Official Full Name
    splicing factor 3b, subunit 3provided by MGI
    Primary source
    MGI:MGI:1289341
    See related
    Ensembl:ENSMUSG00000033732 AllianceGenome:MGI:1289341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RSE1; SAP130; SF3b130; mKIAA0017; D8Ertd633e; 1810061H24Rik; 5730409A01Rik
    Summary
    Predicted to enable U2 snRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and negative regulation of protein catabolic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of U2 snRNP and spliceosomal complex. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human SF3B3 (splicing factor 3b subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 30.3), limb E14.5 (RPKM 23.0) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sf3b3 in Genome Data Viewer
    Location:
    8 E1; 8 57.73 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111537123..111573578, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110810491..110846806, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22681 Neighboring gene interleukin 34 Neighboring gene predicted gene 15894 Neighboring gene predicted gene, 39250 Neighboring gene STARR-seq mESC enhancer starr_22683 Neighboring gene STARR-seq mESC enhancer starr_22685 Neighboring gene small nucleolar RNA, C/D box 111 Neighboring gene predicted gene, 22193 Neighboring gene STARR-positive B cell enhancer ABC_E11398 Neighboring gene component of oligomeric golgi complex 4 Neighboring gene fucose kinase Neighboring gene STARR-positive B cell enhancer ABC_E9743 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 2 Neighboring gene predicted gene, 26132

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity. Guidi R, et al. Cell Rep, 2023 Dec 26. PMID 38096048
    2. Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Li J, et al. Cell Prolif, 2020 Jan. PMID 31794640, Free PMC Article
    3. Sf3b4 regulates chromatin remodeler splicing and Hox expression. Kumar S, et al. Differentiation, 2023 May-Jun. PMID 37167859
    4. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
    5. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.
      Title: Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain type 2 immunity.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables U2 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of U12-type spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of catalytic step 2 spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    splicing factor 3B subunit 3
    Names
    SAP 130
    pre-mRNA-splicing factor SF3b 130 kDa subunit
    spliceosome-associated protein 130

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133953.2 → NP_598714.1  splicing factor 3B subunit 3

      See identical proteins and their annotated locations for NP_598714.1

      Status: VALIDATED

      Source sequence(s)
      AK128988, BC042580, BY126146
      Consensus CDS
      CCDS22665.1
      UniProtKB/Swiss-Prot
      Q3UGI3, Q6ZQL0, Q8BUD9, Q8K2J8, Q921M3
      UniProtKB/TrEMBL
      B2RSV4
      Related
      ENSMUSP00000045073.6, ENSMUST00000042012.7
      Conserved Domains (2) summary
      pfam03178
      Location:863 → 1182
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:76 → 592
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111537123..111573578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530518.5 → XP_006530581.1  splicing factor 3B subunit 3 isoform X1

      See identical proteins and their annotated locations for XP_006530581.1

      UniProtKB/Swiss-Prot
      Q3UGI3, Q6ZQL0, Q8BUD9, Q8K2J8, Q921M3
      UniProtKB/TrEMBL
      B2RSV4
      Conserved Domains (2) summary
      pfam03178
      Location:863 → 1182
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:76 → 592
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term

    2. XM_030243208.2 → XP_030099068.1  splicing factor 3B subunit 3 isoform X2

      Conserved Domains (1) summary
      pfam03178
      Location:296 → 615
      CPSF_A; CPSF A subunit region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q921M3.1 GenPept UniProtKB/Swiss-Prot:Q921M3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous