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    Cdc42bpg CDC42 binding protein kinase gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293693, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Cdc42bpgprovided by RGD
    Official Full Name
    CDC42 binding protein kinase gammaprovided by RGD
    Primary source
    RGD:1307260
    See related
    EnsemblRapid:ENSRNOG00000027456 AllianceGenome:RGD:1307260
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307260
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and peptidyl-threonine phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 154.7), Kidney (RPKM 110.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc42bpg in Genome Data Viewer
    Location:
    1q43
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213037603..213057764)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203608339..203628502)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221673334..221693518)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene microRNA 192 Neighboring gene EH-domain containing 1 Neighboring gene uncharacterized LOC134483959 Neighboring gene menin 1 Neighboring gene mitogen activated protein kinase kinase kinase kinase 2 Neighboring gene uncharacterized LOC134483960

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase gamma is regulated by promoter DNA methylation and Sp1 binding. Ng Y, et al. J Biol Chem, 2004 Aug 13. PMID 15194684
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK gamma
    Names
    CDC42 binding protein kinase gamma (DMPK-like)
    NP_001123485.1
    XP_006230813.1
    XP_038964401.1
    XP_038964412.1
    XP_038964415.1
    XP_038964426.1
    XP_063142946.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130013.1 → NP_001123485.1  serine/threonine-protein kinase MRCK gamma

      See identical proteins and their annotated locations for NP_001123485.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HZG0
      Conserved Domains (6) summary
      pfam08826
      Location:744 → 799
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71 → 337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:938 → 1070
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:879 → 927
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1097 → 1360
      CNH; CNH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213037603..213057764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108498.2 → XP_038964426.1  serine/threonine-protein kinase MRCK gamma isoform X5

      Conserved Domains (5) summary
      cd01243
      Location:846 → 978
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:1 → 301
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:352 → 711
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00780
      Location:1005 → 1268
      CNH; CNH domain
      cd20866
      Location:787 → 838
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

    2. XM_063286876.1 → XP_063142946.1  serine/threonine-protein kinase MRCK gamma isoform X6

    3. XM_039108487.2 → XP_038964415.1  serine/threonine-protein kinase MRCK gamma isoform X3

      Conserved Domains (5) summary
      cd01243
      Location:943 → 1075
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:450 → 809
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00780
      Location:1102 → 1365
      CNH; CNH domain
      cd20866
      Location:884 → 935
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

    4. XM_039108473.1 → XP_038964401.1  serine/threonine-protein kinase MRCK gamma isoform X1

      Conserved Domains (5) summary
      cd01243
      Location:944 → 1076
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:450 → 809
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00780
      Location:1103 → 1366
      CNH; CNH domain
      cd20866
      Location:885 → 936
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

    5. XM_039108484.1 → XP_038964412.1  serine/threonine-protein kinase MRCK gamma isoform X2

      Related
      ENSRNOP00000029466.7, ENSRNOT00000038016.7
      Conserved Domains (5) summary
      cd01243
      Location:944 → 1076
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      TIGR02168
      Location:450 → 809
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam00780
      Location:1103 → 1366
      CNH; CNH domain
      cd20866
      Location:885 → 936
      C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

    6. XM_006230751.5 → XP_006230813.1  serine/threonine-protein kinase MRCK gamma isoform X4

      UniProtKB/TrEMBL
      D3Z837
      Related
      ENSRNOP00000108240.1, ENSRNOT00000135588.1
      Conserved Domains (6) summary
      pfam08826
      Location:744 → 799
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:71 → 337
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd01243
      Location:938 → 1070
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05597
      Location:69 → 399
      STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
      pfam00130
      Location:879 → 927
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam00780
      Location:1097 → 1360
      CNH; CNH domain
    Nucleotide Protein Strain
    Heading Accession and Version

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