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    Mapre2 microtubule-associated protein, RP/EB family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 212307, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mapre2provided by MGI
    Official Full Name
    microtubule-associated protein, RP/EB family, member 2provided by MGI
    Primary source
    MGI:MGI:106271
    See related
    Ensembl:ENSMUSG00000024277 AllianceGenome:MGI:106271
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EB1; EB2; RP1; D18Abb1e; C820009F03Rik
    Summary
    Enables microtubule plus-end binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of ARF protein signal transduction; positive regulation of focal adhesion disassembly; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in congenital symmetric circumferential skin creases 2. Orthologous to human MAPRE2 (microtubule associated protein RP/EB family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 49.0), cerebellum adult (RPKM 47.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mapre2 in Genome Data Viewer
    Location:
    18 A2; 18 12.08 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (23885390..24026918)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (23752333..23893861)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene dystrobrevin alpha Neighboring gene STARR-seq mESC enhancer starr_44043 Neighboring gene predicted gene, 47898 Neighboring gene STARR-seq mESC enhancer starr_44045 Neighboring gene predicted gene 15972 Neighboring gene STARR-positive B cell enhancer ABC_E5648 Neighboring gene microRNA 6360 Neighboring gene predicted gene, 23207 Neighboring gene STARR-seq mESC enhancer starr_44048 Neighboring gene predicted gene, 38559 Neighboring gene zinc finger and SCAN domain containing 30 Neighboring gene predicted gene, 46611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination. Yang Y, et al. Cell Biochem Biophys, 2024 Jun. PMID 38319584
    2. End binding protein-1 (EB1) complements microtubule-associated protein-1B during axonogenesis. Jiménez-Mateos EM, et al. J Neurosci Res, 2005 May 1. PMID 15789376
    3. Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex. Liu H, et al. J Biol Chem, 2015 Dec 25. PMID 26527684, Free PMC Article
    4. NGF-induced axon growth is mediated by localized inactivation of GSK-3beta and functions of the microtubule plus end binding protein APC. Zhou FQ, et al. Neuron, 2004 Jun 24. PMID 15207235
    5. Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity. Jaworski J, et al. Neuron, 2009 Jan 15. PMID 19146815

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
      Title: E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
    2. Knockdown of HAX1 and EB2 in skin epidermal cells stabilizes focal adhesions and impairs epidermal migration.
      Title: Regulation of Focal Adhesion Dynamics and Cell Motility by the EB2 and Hax1 Protein Complex.
    3. Thus, we suggest that EB1 could complement MAP1B function during neural development.
      Title: End binding protein-1 (EB1) complements microtubule-associated protein-1B during axonogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule plus-end binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ARF protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of focal adhesion disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of microtubule polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle midzone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    microtubule-associated protein RP/EB family member 2
    Names
    APC-binding protein EB1
    APC-binding protein EB2
    T-cell activation protein, EB1 family, member 2
    end-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162941.1 → NP_001156413.1  microtubule-associated protein RP/EB family member 2 isoform 2

      See identical proteins and their annotated locations for NP_001156413.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC132419, AK028823, AK148954
      Consensus CDS
      CCDS50237.1
      UniProtKB/TrEMBL
      D3YYK8
      Related
      ENSMUSP00000111496.2, ENSMUST00000115830.8
      Conserved Domains (3) summary
      pfam00307
      Location:49 → 133
      CH; Calponin homology (CH) domain
      pfam03271
      Location:252 → 289
      EB1; EB1-like C-terminal motif
      cl01709
      Location:107 → 164
      PBP2_NikA_DppA_OppA_like; The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold

    2. NM_001162942.1 → NP_001156414.1  microtubule-associated protein RP/EB family member 2 isoform 3

      See identical proteins and their annotated locations for NP_001156414.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC132419, AC145084, AI325879, AK028823, AK148954
      Consensus CDS
      CCDS50238.1
      UniProtKB/TrEMBL
      D3YYK8, E9Q6X0
      Related
      ENSMUSP00000128040.2, ENSMUST00000170802.8
      Conserved Domains (1) summary
      COG5217
      Location:16 → 270
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    3. NM_153058.4 → NP_694698.3  microtubule-associated protein RP/EB family member 2 isoform 1

      See identical proteins and their annotated locations for NP_694698.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132419, AK148954
      Consensus CDS
      CCDS29095.1
      UniProtKB/Swiss-Prot
      Q3UF61, Q8BLZ6, Q8BYR6, Q8C177, Q8K109, Q8R001
      Related
      ENSMUSP00000025127.4, ENSMUST00000025127.5
      Conserved Domains (1) summary
      cl26556
      Location:58 → 312
      EB1; EB1-like C-terminal motif

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      23885390..24026918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525744.3 → XP_006525807.1  microtubule-associated protein RP/EB family member 2 isoform X1

      See identical proteins and their annotated locations for XP_006525807.1

      UniProtKB/TrEMBL
      D3YYK8, E9Q6X0
      Conserved Domains (1) summary
      COG5217
      Location:16 → 270
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    2. XM_036161047.1 → XP_036016940.1  microtubule-associated protein RP/EB family member 2 isoform X1

      UniProtKB/TrEMBL
      D3YYK8, E9Q6X0
      Conserved Domains (1) summary
      COG5217
      Location:16 → 270
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]

    3. XM_006525745.2 → XP_006525808.1  microtubule-associated protein RP/EB family member 2 isoform X2

      UniProtKB/TrEMBL
      D3YYK8
      Conserved Domains (1) summary
      COG5217
      Location:29 → 259
      BIM1; Microtubule-binding protein involved in cell cycle control [Cell division and chromosome partitioning / Cytoskeleton]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R001.1 GenPept UniProtKB/Swiss-Prot:Q8R001

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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