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    BOLA-DYB major histocompatibility complex, class II, DY beta [ Bos taurus (domestic cattle) ]

    Gene ID: 282498, updated on 4-Oct-2024

    Summary

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    Gene symbol
    BOLA-DYB
    Gene description
    major histocompatibility complex, class II, DY beta
    See related
    Ensembl:ENSBTAG00000045923
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    DYB; Bola-DIB
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    Genomic context

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    See BOLA-DYB in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 23 NC_037350.1 (7096988..7113967, complement)

    Chromosome 23 - NC_037350.1Genomic Context describing neighboring genes Neighboring gene MHC class II antigen DS beta Neighboring gene major histocompatibility complex, class II, DY alpha Neighboring gene major histocompatibility complex, class II, DO beta Neighboring gene tRNA wybutosine-synthesizing protein 5-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Partial nucleotide sequence of a novel bovine major histocompatibility complex class II beta-chain gene, BoLA-DIB. Stone RT, et al. Anim Genet, 1990. PMID 2128591
    2. The DY genes of the cattle MHC: expression and comparative analysis of an unusual class II MHC gene pair. Ballingall KT, et al. Immunogenetics, 2004 Feb. PMID 14745522
    3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables MHC class II protein complex binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptide antigen assembly with MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MHC class II protein complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    major histocompatibility complex, class II, DY beta
    Names
    MHC class II antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012679.1 → NP_001012697.1  major histocompatibility complex, class II, DY beta precursor

      See identical proteins and their annotated locations for NP_001012697.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ580584
      UniProtKB/TrEMBL
      Q70IB5, Q95399
      Related
      ENSBTAP00000054535.1, ENSBTAT00000063954.3
      Conserved Domains (2) summary
      cd05766
      Location:127 → 220
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:43 → 114
      MHC_II_beta; Class II histocompatibility antigen, beta domain

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037350.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      7096988..7113967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024983393.2 → XP_024839161.1  major histocompatibility complex, class II, DY beta isoform X1

      Conserved Domains (2) summary
      cd05766
      Location:169 → 262
      IgC_MHC_II_beta; Class II major histocompatibility complex (MHC) beta chain immunoglobulin domain
      pfam00969
      Location:85 → 156
      MHC_II_beta; Class II histocompatibility antigen, beta domain
    Nucleotide Protein Strain
    Heading Accession and Version

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