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    TENT2 terminal nucleotidyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 167153, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TENT2provided by HGNC
    Official Full Name
    terminal nucleotidyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:26776
    See related
    Ensembl:ENSG00000164329 MIM:614121; AllianceGenome:HGNC:26776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APD4; GLD2; TUT2; PAPD4
    Summary
    Enables poly(A) RNA polymerase activity. Involved in histone mRNA catabolic process; mRNA 3'-end processing; and negative regulation of miRNA catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in glutamatergic synapse; perforant pathway to dendrate granule cell synapse; and postsynapse. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 14.6), lymph node (RPKM 12.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TENT2 in Genome Data Viewer
    Location:
    5q14.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (79612441..79688246)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (80096704..80172520)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (78908264..78984069)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901013 Neighboring gene uncharacterized LOC105379047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22726 Neighboring gene uncharacterized LOC124901014 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:78907869-78909068 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78925303-78925804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:78925805-78926304 Neighboring gene NANOG hESC enhancer GRCh37_chr5:78968175-78968748 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:78985169-78985670 Neighboring gene cardiomyopathy associated 5 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:79065865-79066605 Neighboring gene OCT4 hESC enhancer GRCh37_chr5:79067050-79067551 Neighboring gene uncharacterized LOC102724557

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity. Wyman SK, et al. Genome Res, 2011 Sep. PMID 21813625, Free PMC Article
    2. Involvement of hGLD-2 in cytoplasmic polyadenylation of human p53 mRNA. Glahder JA, et al. APMIS, 2011 Nov. PMID 21995630
    3. Mammalian GLD-2 homologs are poly(A) polymerases. Kwak JE, et al. Proc Natl Acad Sci U S A, 2004 Mar 30. PMID 15070731, Free PMC Article
    4. The early noncoding region of human papillomavirus type 16 is regulated by cytoplasmic polyadenylation factors. Glahder JA, et al. Virus Res, 2010 May. PMID 20144904
    5. The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs. Yamagishi R, et al. Nucleic Acids Res, 2016 Apr 7. PMID 26926106, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
      Title: TENT2, TUT4, and TUT7 selectively regulate miRNA sequence and abundance.
    2. DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
      Title: DDX6 is a positive regulator of Ataxin-2/PAPD4 cytoplasmic polyadenylation machinery.
    3. The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
      Title: The RNA-binding protein QKI-7 recruits the poly(A) polymerase GLD-2 for 3' adenylation and selective stabilization of microRNA-122.
    4. The data demonstrate a novel phosphorylation-dependent mechanism to regulate Gld2 activity, revealing tumour suppressor miRNAs(miR-122) as a previously unknown target of Akt1-dependent signalling
      Title: Gld2 activity is regulated by phosphorylation in the N-terminal domain.
    5. our results propose a novel feedback regulatory mechanism for controlling HCV RNA abundance by the viral capsid protein, which is capable of modulating miR-122 activity and stability through the inhibition of GLD-2.
      Title: Hepatitis C Virus Core Protein Promotes miR-122 Destabilization by Inhibiting GLD-2.
    6. QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
      Title: The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.
    7. HBx is a critical protein derived from HBV, which regulates miR-122 via down-regulating Gld2
      Title: HBx down-regulated Gld2 plays a critical role in HBV-related dysregulation of miR-122.
    8. The noncanonical polymerase Gld2 has been implicated in the stabilization of miR-122, possibly through catalyzing 3' monoadenylation
      Title: Specific miRNA stabilization by Gld2-catalyzed monoadenylation.
    9. Study identified TUT7, TUT4, and TUT2 as novel components of the miRNA biogenesis pathway.
      Title: Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs.
    10. poly(A) polymerase Gld2, deadenylase PARN, and translation inhibitory factor neuroguidin (Ngd) are components of a dendritic CPEB-associated polyadenylation apparatus
      Title: Bidirectional control of mRNA translation and synaptic plasticity by the cytoplasmic polyadenylation complex.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog
    Novel locus FER is associated with serum HMW adiponectin levels.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38499

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in histone mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA 3'-end processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in target-directed miRNA degradation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear RNA-directed RNA polymerase complex IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    poly(A) RNA polymerase GLD2
    Names
    PAP associated domain containing 4
    PAP-associated domain-containing protein 4
    TUTase 2
    poly(A) RNA polymerase D4, non-canonical
    terminal uridylyltransferase 2
    NP_001107865.1
    NP_001107866.1
    NP_001284673.1
    NP_001284674.1
    NP_001336477.1
    NP_001336478.1
    NP_001336479.1
    NP_001336480.1
    NP_001336481.1
    NP_001336482.1
    NP_001336483.1
    NP_001375022.1
    NP_001375023.1
    NP_001375024.1
    NP_001375025.1
    NP_001375026.1
    NP_001375027.1
    NP_001375028.1
    NP_001375029.1
    NP_001375030.1
    NP_001375031.1
    NP_001375032.1
    NP_001375034.1
    NP_001375035.1
    NP_001375036.1
    NP_001375037.1
    NP_001375038.1
    NP_001375039.1
    NP_001375040.1
    NP_001375041.1
    NP_001375042.1
    NP_001375043.1
    NP_001375044.1
    NP_001375045.1
    NP_001375046.1
    NP_001375047.1
    NP_001375048.1
    NP_001375049.1
    NP_001375050.1
    NP_001375051.1
    NP_001375052.1
    NP_001375053.1
    NP_001375054.1
    NP_001375055.1
    NP_001375056.1
    NP_001375057.1
    NP_001375058.1
    NP_001375059.1
    NP_001375060.1
    NP_001375061.1
    NP_001375062.1
    NP_001375063.1
    NP_001375064.1
    NP_001375065.1
    NP_001375066.1
    NP_776158.2
    XP_011541522.1
    XP_011541523.1
    XP_011541526.1
    XP_011541527.1
    XP_011541531.1
    XP_016864641.1
    XP_047272800.1
    XP_047272801.1
    XP_047272802.1
    XP_047272803.1
    XP_047272804.1
    XP_047272805.1
    XP_047272806.1
    XP_047272807.1
    XP_047272808.1
    XP_047272809.1
    XP_047272810.1
    XP_047272811.1
    XP_047272812.1
    XP_047272813.1
    XP_047272814.1
    XP_047272815.1
    XP_047272816.1
    XP_047272817.1
    XP_047272818.1
    XP_047272820.1
    XP_054207855.1
    XP_054207856.1
    XP_054207857.1
    XP_054207858.1
    XP_054207859.1
    XP_054207860.1
    XP_054207861.1
    XP_054207862.1
    XP_054207863.1
    XP_054207864.1
    XP_054207865.1
    XP_054207866.1
    XP_054207867.1
    XP_054207868.1
    XP_054207869.1
    XP_054207870.1
    XP_054207871.1
    XP_054207872.1
    XP_054207873.1
    XP_054207874.1
    XP_054207875.1
    XP_054207876.1
    XP_054207877.1
    XP_054207878.1
    XP_054207879.1
    XP_054207880.1
    XP_054207881.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114393.3 → NP_001107865.1  poly(A) RNA polymerase GLD2 isoform 1

      See identical proteins and their annotated locations for NP_001107865.1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    2. NM_001114394.3 → NP_001107866.1  poly(A) RNA polymerase GLD2 isoform 1

      See identical proteins and their annotated locations for NP_001107866.1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Related
      ENSP00000397563.1, ENST00000453514.6
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    3. NM_001297744.3 → NP_001284673.1  poly(A) RNA polymerase GLD2 isoform 2

      See identical proteins and their annotated locations for NP_001284673.1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AW302247, BC047581, DB302918
      Consensus CDS
      CCDS75266.1
      UniProtKB/Swiss-Prot
      Q6PIY7
      Related
      ENSP00000393412.2, ENST00000423041.6
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    4. NM_001297745.3 → NP_001284674.1  poly(A) RNA polymerase GLD2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008482, AL833136, AW302247, BC047581, DB302918
      Consensus CDS
      CCDS75265.1
      UniProtKB/TrEMBL
      D6RAF2
      Related
      ENSP00000421966.1, ENST00000504233.5
      Conserved Domains (2) summary
      cd05402
      Location:176 → 298
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154 → 425
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    5. NM_001349548.2 → NP_001336477.1  poly(A) RNA polymerase GLD2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
      Conserved Domains (1) summary
      cl27230
      Location:4 → 245
      PAP_assoc; Cid1 family poly A polymerase

    6. NM_001349549.2 → NP_001336478.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    7. NM_001349550.2 → NP_001336479.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    8. NM_001349551.2 → NP_001336480.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, DA803910, DB302918
      Conserved Domains (1) summary
      COG5260
      Location:154 → 489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    9. NM_001349552.2 → NP_001336481.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    10. NM_001349553.2 → NP_001336482.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    11. NM_001349554.2 → NP_001336483.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AL833136, AW302247, BC047581, CF137152, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    12. NM_001388093.1 → NP_001375022.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    13. NM_001388094.1 → NP_001375023.1  poly(A) RNA polymerase GLD2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    14. NM_001388095.1 → NP_001375024.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    15. NM_001388096.1 → NP_001375025.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    16. NM_001388097.1 → NP_001375026.1  poly(A) RNA polymerase GLD2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    17. NM_001388098.1 → NP_001375027.1  poly(A) RNA polymerase GLD2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:153 → 488
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    18. NM_001388099.1 → NP_001375028.1  poly(A) RNA polymerase GLD2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 478
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    19. NM_001388100.1 → NP_001375029.1  poly(A) RNA polymerase GLD2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 478
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    20. NM_001388101.1 → NP_001375030.1  poly(A) RNA polymerase GLD2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:154 → 474
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    21. NM_001388102.1 → NP_001375031.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    22. NM_001388103.1 → NP_001375032.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    23. NM_001388105.1 → NP_001375034.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    24. NM_001388106.1 → NP_001375035.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    25. NM_001388107.1 → NP_001375036.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    26. NM_001388108.1 → NP_001375037.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    27. NM_001388109.1 → NP_001375038.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    28. NM_001388110.1 → NP_001375039.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    29. NM_001388111.1 → NP_001375040.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    30. NM_001388112.1 → NP_001375041.1  poly(A) RNA polymerase GLD2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    31. NM_001388113.1 → NP_001375042.1  poly(A) RNA polymerase GLD2 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:153 → 467
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    32. NM_001388114.1 → NP_001375043.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    33. NM_001388115.1 → NP_001375044.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    34. NM_001388116.1 → NP_001375045.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    35. NM_001388117.1 → NP_001375046.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    36. NM_001388118.1 → NP_001375047.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    37. NM_001388119.1 → NP_001375048.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    38. NM_001388120.1 → NP_001375049.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    39. NM_001388121.1 → NP_001375050.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    40. NM_001388122.1 → NP_001375051.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    41. NM_001388123.1 → NP_001375052.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    42. NM_001388124.1 → NP_001375053.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    43. NM_001388125.1 → NP_001375054.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    44. NM_001388126.1 → NP_001375055.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    45. NM_001388127.1 → NP_001375056.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    46. NM_001388128.1 → NP_001375057.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    47. NM_001388129.1 → NP_001375058.1  poly(A) RNA polymerase GLD2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75266.1
      Conserved Domains (1) summary
      COG5260
      Location:154 → 464
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    48. NM_001388130.1 → NP_001375059.1  poly(A) RNA polymerase GLD2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:153 → 463
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    49. NM_001388131.1 → NP_001375060.1  poly(A) RNA polymerase GLD2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:124 → 438
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    50. NM_001388132.1 → NP_001375061.1  poly(A) RNA polymerase GLD2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:124 → 434
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    51. NM_001388133.1 → NP_001375062.1  poly(A) RNA polymerase GLD2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Consensus CDS
      CCDS75265.1
      UniProtKB/TrEMBL
      D6RAF2
      Conserved Domains (2) summary
      cd05402
      Location:176 → 298
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154 → 425
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    52. NM_001388134.1 → NP_001375063.1  poly(A) RNA polymerase GLD2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (2) summary
      cd05402
      Location:176 → 294
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154 → 421
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    53. NM_001388135.1 → NP_001375064.1  poly(A) RNA polymerase GLD2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (2) summary
      cd05402
      Location:176 → 294
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:154 → 421
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    54. NM_001388136.1 → NP_001375065.1  poly(A) RNA polymerase GLD2 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (1) summary
      COG5260
      Location:38 → 348
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    55. NM_001388137.1 → NP_001375066.1  poly(A) RNA polymerase GLD2 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC008482
      Conserved Domains (2) summary
      COG5260
      Location:81 → 270
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      cl11966
      Location:36 → 100
      NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins

    56. NM_173797.5 → NP_776158.2  poly(A) RNA polymerase GLD2 isoform 1

      See identical proteins and their annotated locations for NP_776158.2

      Status: VALIDATED

      Source sequence(s)
      AC008482, AK095818, AW302247, BC047581, CN348312, DA803910, DB302918
      Consensus CDS
      CCDS4048.1
      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927
      Related
      ENSP00000296783.3, ENST00000296783.7
      Conserved Domains (1) summary
      COG5260
      Location:154 → 468
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      79612441..79688246
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011543221.4 → XP_011541523.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541523.1

      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    2. XM_047416850.1 → XP_047272806.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927

    3. XM_047416857.1 → XP_047272813.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2

    4. XM_047416846.1 → XP_047272802.1  poly(A) RNA polymerase GLD2 isoform X2

    5. XM_011543220.4 → XP_011541522.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541522.1

      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    6. XM_047416856.1 → XP_047272812.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2

    7. XM_017009152.3 → XP_016864641.1  poly(A) RNA polymerase GLD2 isoform X2

      Conserved Domains (1) summary
      COG5260
      Location:154 → 489
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    8. XM_047416859.1 → XP_047272815.1  poly(A) RNA polymerase GLD2 isoform X7

    9. XM_011543229.4 → XP_011541531.1  poly(A) RNA polymerase GLD2 isoform X5

      Conserved Domains (2) summary
      cd05402
      Location:176 → 323
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      pfam03828
      Location:368 → 422
      PAP_assoc; Cid1 family poly A polymerase

    10. XM_047416851.1 → XP_047272807.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927

    11. XM_047416853.1 → XP_047272809.1  poly(A) RNA polymerase GLD2 isoform X4

    12. XM_047416844.1 → XP_047272800.1  poly(A) RNA polymerase GLD2 isoform X1

    13. XM_047416852.1 → XP_047272808.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927

    14. XM_047416848.1 → XP_047272804.1  poly(A) RNA polymerase GLD2 isoform X2

    15. XM_047416854.1 → XP_047272810.1  poly(A) RNA polymerase GLD2 isoform X4

    16. XM_011543225.3 → XP_011541527.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541527.1

      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    17. XM_047416858.1 → XP_047272814.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2

    18. XM_047416845.1 → XP_047272801.1  poly(A) RNA polymerase GLD2 isoform X1

    19. XM_047416849.1 → XP_047272805.1  poly(A) RNA polymerase GLD2 isoform X2

    20. XM_047416855.1 → XP_047272811.1  poly(A) RNA polymerase GLD2 isoform X4

    21. XM_011543224.3 → XP_011541526.1  poly(A) RNA polymerase GLD2 isoform X1

      See identical proteins and their annotated locations for XP_011541526.1

      Conserved Domains (1) summary
      COG5260
      Location:154 → 493
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    22. XM_047416847.1 → XP_047272803.1  poly(A) RNA polymerase GLD2 isoform X2

    23. XM_047416862.1 → XP_047272818.1  poly(A) RNA polymerase GLD2 isoform X10

    24. XM_047416860.1 → XP_047272816.1  poly(A) RNA polymerase GLD2 isoform X8

    25. XM_047416861.1 → XP_047272817.1  poly(A) RNA polymerase GLD2 isoform X9

    26. XM_047416864.1 → XP_047272820.1  poly(A) RNA polymerase GLD2 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      80096704..80172520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351881.1 → XP_054207856.1  poly(A) RNA polymerase GLD2 isoform X1

    2. XM_054351891.1 → XP_054207866.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927

    3. XM_054351899.1 → XP_054207874.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2

    4. XM_054351887.1 → XP_054207862.1  poly(A) RNA polymerase GLD2 isoform X2

    5. XM_054351880.1 → XP_054207855.1  poly(A) RNA polymerase GLD2 isoform X1

    6. XM_054351898.1 → XP_054207873.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2

    7. XM_054351886.1 → XP_054207861.1  poly(A) RNA polymerase GLD2 isoform X2

    8. XM_054351901.1 → XP_054207876.1  poly(A) RNA polymerase GLD2 isoform X7

    9. XM_054351897.1 → XP_054207872.1  poly(A) RNA polymerase GLD2 isoform X5

    10. XM_054351892.1 → XP_054207867.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927

    11. XM_054351894.1 → XP_054207869.1  poly(A) RNA polymerase GLD2 isoform X4

    12. XM_054351884.1 → XP_054207859.1  poly(A) RNA polymerase GLD2 isoform X1

    13. XM_054351893.1 → XP_054207868.1  poly(A) RNA polymerase GLD2 isoform X3

      UniProtKB/Swiss-Prot
      Q6PIY7, Q86WZ2, Q8N927

    14. XM_054351889.1 → XP_054207864.1  poly(A) RNA polymerase GLD2 isoform X2

    15. XM_054351895.1 → XP_054207870.1  poly(A) RNA polymerase GLD2 isoform X4

    16. XM_054351883.1 → XP_054207858.1  poly(A) RNA polymerase GLD2 isoform X1

    17. XM_054351900.1 → XP_054207875.1  poly(A) RNA polymerase GLD2 isoform X6

      UniProtKB/TrEMBL
      D6RAF2

    18. XM_054351885.1 → XP_054207860.1  poly(A) RNA polymerase GLD2 isoform X1

    19. XM_054351890.1 → XP_054207865.1  poly(A) RNA polymerase GLD2 isoform X2

    20. XM_054351896.1 → XP_054207871.1  poly(A) RNA polymerase GLD2 isoform X4

    21. XM_054351882.1 → XP_054207857.1  poly(A) RNA polymerase GLD2 isoform X1

    22. XM_054351888.1 → XP_054207863.1  poly(A) RNA polymerase GLD2 isoform X2

    23. XM_054351906.1 → XP_054207881.1  poly(A) RNA polymerase GLD2 isoform X11

    24. XM_054351904.1 → XP_054207879.1  poly(A) RNA polymerase GLD2 isoform X10

    25. XM_054351902.1 → XP_054207877.1  poly(A) RNA polymerase GLD2 isoform X8

    26. XM_054351903.1 → XP_054207878.1  poly(A) RNA polymerase GLD2 isoform X9

    27. XM_054351905.1 → XP_054207880.1  poly(A) RNA polymerase GLD2 isoform X11

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PIY7.1 GenPept UniProtKB/Swiss-Prot:Q6PIY7

    Gene LinkOut

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