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    ain1 alpha-actinin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542805, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ain1
    Official Full Name
    alpha-actinin
    Primary source
    PomBase:SPAC15A10.08
    Locus tag
    SPOM_SPAC15A10.08
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ain1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (3692790..3695013)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene CPA1 sodium ion/proton antiporter Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SUR7 family protein Neighboring gene muskelin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterisation of Schizosaccharomyces pombe α-actinin. Addario B, et al. PeerJ, 2016. PMID 27069798, Free PMC Article
    2. Molecular dissection of the actin-binding ability of the fission yeast α-actinin, Ain1, in vitro and in vivo. Morita R, et al. J Biochem, 2017 Aug 1. PMID 28338873
    3. Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast. Christensen JR, et al. Elife, 2019 Jun 10. PMID 31180322, Free PMC Article
    4. The F-actin bundler α-actinin Ain1 is tailored for ring assembly and constriction during cytokinesis in fission yeast. Li Y, et al. Mol Biol Cell, 2016 Jun 1. PMID 27075176, Free PMC Article
    5. ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly. Zhang D, et al. Curr Biol, 2016 Mar 7. PMID 26877082, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data sugest that fimbrin (Fim1) competes with alpha-actinin (Ain1) for association with F-actin, and prevents tropomyosin Cdc8's association with actin patches.
      Title: Cooperation between tropomyosin and α-actinin inhibits fimbrin association with actin filament networks in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables actin filament binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin lateral binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables actin lateral binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin crosslink formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actomyosin contractile ring assembly actin filament bundle convergence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actomyosin contractile ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic actomyosin contractile ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    alpha-actinin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3692790..3695013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019718.3 → NP_594295.1  alpha-actinin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594295.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13728
      Conserved Domains (3) summary
      COG5069
      Location:1 → 616
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
      cd00014
      Location:125 → 229
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam08726
      Location:554 → 615
      EFhand_Ca_insen; Ca2+ insensitive EF hand
    Nucleotide Protein
    Heading Accession and Version

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