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    cgs1 cAMP-dependent protein kinase regulatory subunit Cgs1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543351, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cgs1
    Official Full Name
    cAMP-dependent protein kinase regulatory subunit Cgs1
    Primary source
    PomBase:SPAC8C9.03
    Locus tag
    SPOM_SPAC8C9.03
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rak1
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    Genomic context

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    See cgs1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (3643029..3645636)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA-binding forkhead transcription factor for ribosomal proteins Fhl1 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene D-Tyr-tRNA deacylase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Kawamukai M, et al. Cell Regul, 1991 Feb. PMID 1863602, Free PMC Article
    2. Complex formation, phosphorylation, and localization of protein kinase A of Schizosaccharomyces pombe upon glucose starvation. Gupta DR, et al. Biosci Biotechnol Biochem, 2011. PMID 21869531
    3. Regulation of the subcellular localization of cyclic AMP-dependent protein kinase in response to physiological stresses and sexual differentiation in the fission yeast Schizosaccharomyces pombe. Matsuo Y, et al. Eukaryot Cell, 2008 Sep. PMID 18621924, Free PMC Article
    4. The sak1+ gene of Schizosaccharomyces pombe encodes an RFX family DNA-binding protein that positively regulates cyclic AMP-dependent protein kinase-mediated exit from the mitotic cell cycle. Wu SY, et al. Mol Cell Biol, 1995 Mar. PMID 7862141, Free PMC Article
    5. A zinc-finger protein, Rst2p, regulates transcription of the fission yeast ste11(+) gene, which encodes a pivotal transcription factor for sexual development. Kunitomo H, et al. Mol Biol Cell, 2000 Sep. PMID 10982411, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hyperphosphorylation of Pka1 depends on Cgs1 interaction.
      Title: Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.
    2. In the tor2-51 cgs1Delta double mutant no G1-arrested cells were observed 8 hours after Tor2 inactivation, indicating that the TOR and the PKA pathways cooperate to prevent cell cycle exit and G1 arrest in fission yeast.
      Title: TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.
    3. Nuclear-cytoplasmic redistribution of Cgs1p and Pka1p is triggered by growth in glucose-limited or hyperosmotic media and in response to stationary-phase growth.
      Title: Regulation of the subcellular localization of cyclic AMP-dependent protein kinase in response to physiological stresses and sexual differentiation in the fission yeast Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase inhibitor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables cAMP-dependent protein kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP-dependent protein kinase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    		  
    involved_in positive regulation of protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cAMP-dependent protein kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cAMP-dependent protein kinase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cAMP-dependent protein kinase regulatory subunit Cgs1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3643029..3645636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019697.3 → NP_594274.1  cAMP-dependent protein kinase regulatory subunit Cgs1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594274.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14272, P36600
      Conserved Domains (4) summary
      smart00100
      Location:143 → 275
      cNMP; Cyclic nucleotide-monophosphate binding domain
      COG0664
      Location:141 → 276
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:278 → 385
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cl02594
      Location:1 → 38
      DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
    Nucleotide Protein
    Heading Accession and Version

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