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    Zyx zyxin [ Mus musculus (house mouse) ]

    Gene ID: 22793, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zyxprovided by MGI
    Official Full Name
    zyxinprovided by MGI
    Primary source
    MGI:MGI:103072
    See related
    Ensembl:ENSMUSG00000029860 AllianceGenome:MGI:103072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530098H06Rik
    Summary
    Predicted to enable metal ion binding activity. Involved in cell-matrix adhesion; integrin-mediated signaling pathway; and transforming growth factor beta receptor signaling pathway. Acts upstream of or within cellular response to type II interferon. Located in focal adhesion and phagocytic vesicle. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and heart. Orthologous to human ZYX (zyxin). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 88.7), ovary adult (RPKM 71.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zyx in Genome Data Viewer
    Location:
    6 B2.1; 6 20.64 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42326507..42337158)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42349511..42360213)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 1 Neighboring gene family with sequence similarity 131, member B Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42293816-42293969 Neighboring gene predicted gene, 24611 Neighboring gene RIKEN cDNA 2010310C07 gene Neighboring gene Eph receptor A1 Neighboring gene STARR-seq mESC enhancer starr_15718 Neighboring gene taste receptor, type 2, member 143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface. Zhang S, et al. Commun Biol, 2023 Jan 18. PMID 36653484, Free PMC Article
    2. A mechanical-biochemical feedback loop regulates remodeling in the actin cytoskeleton. Stachowiak MR, et al. Proc Natl Acad Sci U S A, 2014 Dec 9. PMID 25422436, Free PMC Article
    3. Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators. Hoffman LM, et al. Mol Biol Cell, 2012 May. PMID 22456508, Free PMC Article
    4. The LIM Protein Zyxin Binds CARP-1 and Promotes Apoptosis. Hervy M, et al. Genes Cancer, 2010 May 1. PMID 20852740, Free PMC Article
    5. A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Smith MA, et al. Dev Cell, 2010 Sep 14. PMID 20833360, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
      Title: Zyxin is important for the stability and function of podocytes, especially during mechanical stretch.
    2. Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
      Title: Zyxin regulates embryonic stem cell fate by modulating mechanical and biochemical signaling interface.
    3. Zyxin protects from hypertension-induced cardiac dysfunction.
      Title: Zyxin protects from hypertension-induced cardiac dysfunction.
    4. Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
      Title: Essential role of zyxin in platelet biogenesis and glycoprotein Ib-IX surface expression.
    5. Study findings identify zyxin as a physiological regulator of endothelial exocytosis through reorganizing local actin network in the final stage of exocytosis. Zyxin-deficient mice exhibit impaired epinephrine-stimulated VWF release, prolonged bleeding time and thrombosis, largely due to defective endothelial secretion of VWF.
      Title: Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.
    6. these observations suggest that Zyxin promotes colon cancer tumorigenesis in a mitotic-phosphorylation-dependent manner and through CDK8-mediated YAP activation.
      Title: Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation.
    7. zyxin influences focal adhesion dynamics, that it recruits Tes and that this interaction is functional in regulating cell spreading.
      Title: Delineating the Tes Interaction Site in Zyxin and Studying Cellular Effects of Its Disruption.
    8. Zyxin contributes to the migratory and invasive phenotype evoked by Tead2.
      Title: Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.
    9. Integrin-beta5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor beta.
      Title: Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β.
    10. paxillin and zyxin are LIM-domain adaptor proteins that are recruited to stress fiber strain sites
      Title: LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in integrin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zyxin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289617.2 → NP_001276546.1  zyxin isoform a

      See identical proteins and their annotated locations for NP_001276546.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC153915
      Consensus CDS
      CCDS20066.1
      UniProtKB/Swiss-Prot
      P70461, Q3UGQ3, Q62523
      UniProtKB/TrEMBL
      Q3TCR9
      Related
      ENSMUSP00000126622.2, ENSMUST00000164375.4
      Conserved Domains (4) summary
      cd09353
      Location:436 → 495
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:496 → 562
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:175 → 368
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:343 → 429
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001289618.2 → NP_001276547.1  zyxin isoform b

      See identical proteins and their annotated locations for NP_001276547.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon and differs in the 3' UTR, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AC153915
      Consensus CDS
      CCDS85034.1
      UniProtKB/TrEMBL
      Q3TCR9, Q7TQE2
      Related
      ENSMUSP00000145236.2, ENSMUST00000203401.3
      Conserved Domains (4) summary
      cd09353
      Location:405 → 464
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:465 → 531
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:5 → 311
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:312 → 398
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001289619.2 → NP_001276548.1  zyxin isoform b

      See identical proteins and their annotated locations for NP_001276548.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 3 and 4 encode the same isoform (b).
      Source sequence(s)
      AC153915
      Consensus CDS
      CCDS85034.1
      UniProtKB/TrEMBL
      Q3TCR9, Q7TQE2
      Related
      ENSMUSP00000070427.8, ENSMUST00000070635.13
      Conserved Domains (4) summary
      cd09353
      Location:405 → 464
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:465 → 531
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:5 → 311
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:312 → 398
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. NM_001415802.1 → NP_001402731.1  zyxin isoform a

      Status: VALIDATED

      Source sequence(s)
      AC153915
      UniProtKB/Swiss-Prot
      P70461, Q3UGQ3, Q62523

    5. NM_011777.4 → NP_035907.1  zyxin isoform a

      See identical proteins and their annotated locations for NP_035907.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AC153915
      Consensus CDS
      CCDS20066.1
      UniProtKB/Swiss-Prot
      P70461, Q3UGQ3, Q62523
      UniProtKB/TrEMBL
      Q3TCR9
      Related
      ENSMUSP00000145451.2, ENSMUST00000203652.3
      Conserved Domains (4) summary
      cd09353
      Location:436 → 495
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:496 → 562
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:175 → 368
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:343 → 429
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      42326507..42337158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255327.2 → XP_030111187.1  zyxin isoform X2

      UniProtKB/TrEMBL
      Q3TCR9, Q7TQE2
      Conserved Domains (4) summary
      cd09353
      Location:405 → 464
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:465 → 531
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:5 → 311
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:312 → 398
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. XM_036166031.1 → XP_036021924.1  zyxin isoform X2

      UniProtKB/TrEMBL
      Q3TCR9, Q7TQE2
      Conserved Domains (4) summary
      cd09353
      Location:405 → 464
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:465 → 531
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:5 → 311
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:312 → 398
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_036166032.1 → XP_036021925.1  zyxin isoform X3

      UniProtKB/TrEMBL
      Q8CD55
      Conserved Domains (4) summary
      cd09353
      Location:337 → 396
      LIM2_Zyxin; The second LIM domain of Zyxin
      cd09435
      Location:397 → 463
      LIM3_Zyxin; The third LIM domain of Zyxin
      PHA03247
      Location:76 → 269
      PHA03247; large tegument protein UL36; Provisional
      cl02475
      Location:244 → 330
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62523.2 GenPept UniProtKB/Swiss-Prot:Q62523

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