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    Dock10 dedicator of cytokinesis 10 [ Mus musculus (house mouse) ]

    Gene ID: 210293, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Dock10provided by MGI
    Official Full Name
    dedicator of cytokinesis 10provided by MGI
    Primary source
    MGI:MGI:2146320
    See related
    Ensembl:ENSMUSG00000038608 AllianceGenome:MGI:2146320
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jr4; Jr5; ZIZ3; Zizimin3; mKIAA0694; 9330153B10Rik; A630054M16Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in several processes, including dendritic spine morphogenesis; marginal zone B cell differentiation; and regulation of postsynapse assembly. Located in dendritic spine. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including central nervous system; endocrine gland; retina; thymus primordium; and trigeminal nerve. Orthologous to human DOCK10 (dedicator of cytokinesis 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in spleen adult (RPKM 3.8), frontal lobe adult (RPKM 3.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dock10 in Genome Data Viewer
    Location:
    1 C5; 1 41.41 cM
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (80478785..80736482, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (80501068..80758765, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01459 Neighboring gene STARR-seq mESC enhancer starr_01460 Neighboring gene STARR-positive B cell enhancer mm9_chr1:80415486-80415786 Neighboring gene RIKEN cDNA 1700016L21 gene Neighboring gene GLE1 RNA export mediator pseudogene Neighboring gene predicted gene, 38673 Neighboring gene STARR-seq mESC enhancer starr_01461 Neighboring gene STARR-positive B cell enhancer ABC_E10018 Neighboring gene STARR-positive B cell enhancer mm9_chr1:80743907-80744208 Neighboring gene STARR-seq mESC enhancer starr_01462 Neighboring gene STARR-seq mESC enhancer starr_01463 Neighboring gene neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 Neighboring gene STARR-seq mESC enhancer starr_01464 Neighboring gene STARR-seq mESC enhancer starr_01465 Neighboring gene STARR-seq mESC enhancer starr_01466 Neighboring gene R3H domain containing 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor. Kukimoto-Niino M, et al. Biochem Biophys Res Commun, 2023 Apr 23. PMID 36848820
    2. The role of DOCK10 in the regulation of the transcriptome and aging. Ruiz-Lafuente N, et al. Heliyon, 2019 Mar. PMID 30963125, Free PMC Article
    3. Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes. Alcaraz-García MJ, et al. Hum Immunol, 2011 Jul. PMID 21514340
    4. Dock10 Regulates Cardiac Function under Neurohormonal Stress. Segal L, et al. Int J Mol Sci, 2022 Aug 25. PMID 36077014, Free PMC Article
    5. Deletion of Dock10 in B Cells Results in Normal Development but a Mild Deficiency upon In Vivo and In Vitro Stimulations. Gerasimčik N, et al. Front Immunol, 2017. PMID 28507547, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
      Title: Structural basis for the dual GTPase specificity of the DOCK10 guanine nucleotide exchange factor.
    2. Dock10 Regulates Cardiac Function under Neurohormonal Stress.
      Title: Dock10 Regulates Cardiac Function under Neurohormonal Stress.
    3. Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function
      Title: Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue.
    4. DOCK10 function in dendritic spine morphogenesis is mediated mainly by Cdc42 and its downstream effectors N-WASP and PAK3, although DOCK10 is also able to activate Rac1.
      Title: The RhoGEF DOCK10 is essential for dendritic spine morphogenesis.
    5. T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms
      Title: Human and mouse DOCK10 splicing isoforms with alternative first coding exon usage are differentially expressed in T and B lymphocytes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC183664

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in marginal zone B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 10
    Names
    zizimin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285927.2 → NP_001272856.1  dedicator of cytokinesis protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001272856.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, alternatively referred to as DOCK10.2) contains an alternate first exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC124672, AC132387
      Consensus CDS
      CCDS78626.1
      UniProtKB/TrEMBL
      B2RWY0
      Related
      ENSMUSP00000140085.2, ENSMUST00000187774.7
      Conserved Domains (5) summary
      cd08697
      Location:659 → 848
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1684 → 2129
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:170 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:170 → 277
      PH; PH domain
      pfam11878
      Location:54 → 141
      DUF3398; Domain of unknown function (DUF3398)

    2. NM_001406554.1 → NP_001393483.1  dedicator of cytokinesis protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124672, AC132387

    3. NM_001406555.1 → NP_001393484.1  dedicator of cytokinesis protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC124672, AC132387
      UniProtKB/TrEMBL
      A0A087WRP5
      Related
      ENSMUSP00000140719.2, ENSMUST00000190983.7

    4. NM_175291.5 → NP_780500.2  dedicator of cytokinesis protein 10 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, alternatively referred to as DOCK10.1) encodes the longer isoform (1).
      Source sequence(s)
      AC124672, AC132387
      Consensus CDS
      CCDS48297.1
      UniProtKB/Swiss-Prot
      A0A087WQ86, E9QM99, F1AHI9, Q8BZN6
      UniProtKB/TrEMBL
      B2RWY0
      Related
      ENSMUSP00000077099.6, ENSMUST00000077946.12
      Conserved Domains (5) summary
      cd08697
      Location:671 → 860
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1696 → 2141
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:182 → 302
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam00169
      Location:182 → 289
      PH; PH domain
      pfam11878
      Location:66 → 153
      DUF3398; Domain of unknown function (DUF3398)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      80478785..80736482 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252604.2 → XP_030108464.1  dedicator of cytokinesis protein 10 isoform X20

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1786 → 2198
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    2. XM_036163169.1 → XP_036019062.1  dedicator of cytokinesis protein 10 isoform X19

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1786 → 2198
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    3. XM_006496475.5 → XP_006496538.3  dedicator of cytokinesis protein 10 isoform X18

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1786 → 2200
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    4. XM_006496470.5 → XP_006496533.3  dedicator of cytokinesis protein 10 isoform X12

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2233
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    5. XM_006496469.5 → XP_006496532.3  dedicator of cytokinesis protein 10 isoform X10

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2233
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    6. XM_030252603.2 → XP_030108463.1  dedicator of cytokinesis protein 10 isoform X13

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1777 → 2222
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    7. XM_017319527.3 → XP_017175016.2  dedicator of cytokinesis protein 10 isoform X11

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2231
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    8. XM_017319532.3 → XP_017175021.2  dedicator of cytokinesis protein 10 isoform X16

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2233
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    9. XM_030252594.2 → XP_030108454.1  dedicator of cytokinesis protein 10 isoform X5

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1777 → 2222
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    10. XM_006496466.5 → XP_006496529.3  dedicator of cytokinesis protein 10 isoform X4

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1777 → 2224
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    11. XM_006496468.5 → XP_006496531.3  dedicator of cytokinesis protein 10 isoform X7

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1786 → 2198
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    12. XM_006496467.5 → XP_006496530.3  dedicator of cytokinesis protein 10 isoform X6

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)
      cl06123
      Location:1786 → 2200
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins

    13. XM_006496465.5 → XP_006496528.3  dedicator of cytokinesis protein 10 isoform X3

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2231
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    14. XM_036163168.1 → XP_036019061.1  dedicator of cytokinesis protein 10 isoform X17

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2231
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    15. XM_006496463.5 → XP_006496526.3  dedicator of cytokinesis protein 10 isoform X1

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:761 → 950
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1786 → 2233
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:272 → 392
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:135 → 245
      DUF3398; Domain of unknown function (DUF3398)

    16. XM_006496464.5 → XP_006496527.2  dedicator of cytokinesis protein 10 isoform X2

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:670 → 859
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1695 → 2142
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:181 → 301
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:44 → 154
      DUF3398; Domain of unknown function (DUF3398)

    17. XM_006496471.5 → XP_006496534.1  dedicator of cytokinesis protein 10 isoform X14

      See identical proteins and their annotated locations for XP_006496534.1

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:659 → 848
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1684 → 2131
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:170 → 290
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:33 → 143
      DUF3398; Domain of unknown function (DUF3398)

    18. XM_036163163.1 → XP_036019056.1  dedicator of cytokinesis protein 10 isoform X9

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:683 → 872
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1708 → 2155
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:194 → 314
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:57 → 167
      DUF3398; Domain of unknown function (DUF3398)

    19. XM_017319519.3 → XP_017175008.1  dedicator of cytokinesis protein 10 isoform X8

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:684 → 873
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1709 → 2156
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:195 → 315
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:58 → 168
      DUF3398; Domain of unknown function (DUF3398)

    20. XM_036163166.1 → XP_036019059.1  dedicator of cytokinesis protein 10 isoform X15

      UniProtKB/TrEMBL
      B2RWY0
      Conserved Domains (4) summary
      cd08697
      Location:658 → 847
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1683 → 2130
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10
      cd13267
      Location:169 → 289
      PH_DOCK-D; Dedicator of cytokinesis-D subfamily Pleckstrin homology (PH) domain
      pfam11878
      Location:32 → 142
      DUF3398; Domain of unknown function (DUF3398)

    21. XM_011238683.4 → XP_011236985.1  dedicator of cytokinesis protein 10 isoform X23

      UniProtKB/TrEMBL
      A0A0R4J2B7
      Related
      ENSMUSP00000139567.2, ENSMUST00000190595.7
      Conserved Domains (2) summary
      cd08697
      Location:156 → 345
      C2_Dock-D; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
      cd11699
      Location:1181 → 1628
      DHR2_DOCK10; Dock Homology Region 2, a GEF domain, of Class D Dedicator of Cytokinesis 10

    RNA

    1. XR_373539.5 RNA Sequence

    2. XR_003954321.2 RNA Sequence

    3. XR_003954322.1 RNA Sequence

    4. XR_003954323.1 RNA Sequence

    5. XR_001783679.3 RNA Sequence

    6. XR_003954325.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZN6.4 GenPept UniProtKB/Swiss-Prot:Q8BZN6

    Gene LinkOut

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