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    Znrf1 zinc and ring finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 170737, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Znrf1provided by MGI
    Official Full Name
    zinc and ring finger 1provided by MGI
    Primary source
    MGI:MGI:2177308
    See related
    Ensembl:ENSMUSG00000033545 AllianceGenome:MGI:2177308
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnf42; Zrfp1; nin283; B830022L21Rik
    Summary
    Enables ubiquitin protein ligase activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K48-linked ubiquitination. Predicted to be located in cytosol and endosome. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in several structures, including central nervous system; genitourinary system; and retina nuclear layer. Orthologous to human ZNRF1 (zinc and ring finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 159.2), whole brain E14.5 (RPKM 40.2) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Znrf1 in Genome Data Viewer
    Location:
    8 E1; 8 57.98 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112262652..112352352)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111536484..111625720)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22695 Neighboring gene predicted gene, 24793 Neighboring gene WD repeat domain 59 Neighboring gene STARR-positive B cell enhancer ABC_E112 Neighboring gene STARR-seq mESC enhancer starr_22698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114079308-114079417 Neighboring gene STARR-positive B cell enhancer ABC_E5041 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114087696-114087913 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114116137-114116338 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114119771-114119993 Neighboring gene STARR-seq mESC enhancer starr_22705 Neighboring gene STARR-positive B cell enhancer ABC_E9323 Neighboring gene STARR-positive B cell enhancer ABC_E885 Neighboring gene STARR-positive B cell enhancer ABC_E5042 Neighboring gene STARR-seq mESC enhancer starr_22707 Neighboring gene lactate dehydrogenase D Neighboring gene STARR-seq mESC enhancer starr_22708 Neighboring gene zinc finger protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E10523 Neighboring gene microRNA 7076 Neighboring gene chymotrypsinogen B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration. Wakatsuki S, et al. J Cell Biol, 2015 Nov 23. PMID 26572622, Free PMC Article
    2. Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery. Araki T, et al. J Biol Chem, 2001 Sep 7. PMID 11427537
    3. The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation. Lee CY, et al. Nat Commun, 2017 Jun 8. PMID 28593998, Free PMC Article
    4. ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases. Araki T, et al. J Neurosci, 2003 Oct 15. PMID 14561866, Free PMC Article
    5. ZNRF1 interacts with tubulin and regulates cell morphogenesis. Yoshida K, et al. Biochem Biophys Res Commun, 2009 Nov 20. PMID 19737534

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study defines ZNRF1 as a regulator of TLR4-induced inflammatory responses and reveals another mechanism for the regulation of TLR4 signalling through CAV1.
      Title: The ubiquitin ligase ZNRF1 promotes caveolin-1 ubiquitination and degradation to modulate inflammation.
    2. up-regulation of ZNRF1 activity by oxidative stress leads to neuronal apoptosis and Wallerian degeneration.
      Title: Oxidative stress-dependent phosphorylation activates ZNRF1 to induce neuronal/axonal degeneration.
    3. The ZNRF1-AKT-GSK3B-CRMP2 pathway plays an important role in controlling Wallerian degeneration.
      Title: ZNRF1 promotes Wallerian degeneration by degrading AKT to induce GSK3B-dependent CRMP2 phosphorylation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC101991

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of autophagosome-lysosome fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of autophagosome-lysosome fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of toll-like receptor 4 signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ZNRF1
    Names
    RING-type E3 ubiquitin transferase ZNRF1
    nerve injury-induced gene 283 protein
    peripheral nerve injury protein nin283
    ring finger protein 42
    zinc ring finger protein 1
    zinc/RING finger protein 1
    NP_001162092.1
    NP_001162093.1
    NP_001162094.1
    NP_001350417.1
    NP_001350418.1
    NP_573469.1
    XP_036009665.1
    XP_036009666.1
    XP_036009667.1
    XP_036009668.1
    XP_036009669.1
    XP_036009670.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168621.3 → NP_001162092.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

      See identical proteins and their annotated locations for NP_001162092.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122364, AC127356
      Consensus CDS
      CCDS22676.1
      UniProtKB/Swiss-Prot
      Q8C5D7, Q91V17
      Related
      ENSMUSP00000126684.2, ENSMUST00000168428.8
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    2. NM_001168622.3 → NP_001162093.1  E3 ubiquitin-protein ligase ZNRF1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC122364, AC127356
      Consensus CDS
      CCDS52673.1
      UniProtKB/TrEMBL
      E9PZB7
      Related
      ENSMUSP00000127956.2, ENSMUST00000171182.8
      Conserved Domains (1) summary
      cd16694
      Location:150 → 195
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    3. NM_001168623.2 → NP_001162094.1  E3 ubiquitin-protein ligase ZNRF1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct N-terminus compared to isoform a. Variants 4 and 6 both encode the same isoform (c).
      Source sequence(s)
      AC122364, AC127356
      Consensus CDS
      CCDS52674.1
      UniProtKB/TrEMBL
      E9PWL2
      Related
      ENSMUSP00000132939.2, ENSMUST00000166859.8
      Conserved Domains (1) summary
      cd16694
      Location:82 → 127
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    4. NM_001363488.2 → NP_001350417.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR compared to variant 1. Variants 1, 2, and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122364, AC127356
      Consensus CDS
      CCDS22676.1
      UniProtKB/Swiss-Prot
      Q8C5D7, Q91V17
      Related
      ENSMUSP00000133993.2, ENSMUST00000173506.8
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    5. NM_001363489.1 → NP_001350418.1  E3 ubiquitin-protein ligase ZNRF1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 4, encodes isoform c.
      Source sequence(s)
      AC122364, AC127356
      Consensus CDS
      CCDS52674.1
      UniProtKB/TrEMBL
      E9PWL2
      Related
      ENSMUSP00000134634.2, ENSMUST00000174333.8
      Conserved Domains (1) summary
      cd16694
      Location:82 → 127
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    6. NM_133206.5 → NP_573469.1  E3 ubiquitin-protein ligase ZNRF1 isoform a

      See identical proteins and their annotated locations for NP_573469.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 5 all encode the same isoform (a).
      Source sequence(s)
      AC122364, AC127356
      Consensus CDS
      CCDS22676.1
      UniProtKB/Swiss-Prot
      Q8C5D7, Q91V17
      Related
      ENSMUSP00000092799.6, ENSMUST00000095176.12
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    RNA

    1. NR_156703.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122364, AC127356

    2. NR_156704.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) contains an alternate exon and differs in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC122364, AC127356

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112262652..112352352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153772.1 → XP_036009665.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      UniProtKB/Swiss-Prot
      Q8C5D7, Q91V17
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    2. XM_036153773.1 → XP_036009666.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      UniProtKB/Swiss-Prot
      Q8C5D7, Q91V17
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    3. XM_036153774.1 → XP_036009667.1  E3 ubiquitin-protein ligase ZNRF1 isoform X1

      UniProtKB/Swiss-Prot
      Q8C5D7, Q91V17
      Related
      ENSMUSP00000133309.2, ENSMUST00000172856.8
      Conserved Domains (1) summary
      cd16694
      Location:182 → 227
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    4. XM_036153775.1 → XP_036009668.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      E9PZB7
      Conserved Domains (1) summary
      cd16694
      Location:150 → 195
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    5. XM_036153776.1 → XP_036009669.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      E9PZB7
      Conserved Domains (1) summary
      cd16694
      Location:150 → 195
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins

    6. XM_036153777.1 → XP_036009670.1  E3 ubiquitin-protein ligase ZNRF1 isoform X2

      UniProtKB/TrEMBL
      E9PZB7
      Conserved Domains (1) summary
      cd16694
      Location:150 → 195
      mRING-CH-C4HC2H_ZNRF1; Modified RING-CH finger, H2 subclass (C4HC2H-type), found in zinc/RING finger protein 1 (ZNRF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91V17.1 GenPept UniProtKB/Swiss-Prot:Q91V17

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