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    Cstf2 cleavage stimulation factor, 3' pre-RNA subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 108062, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cstf2provided by MGI
    Official Full Name
    cleavage stimulation factor, 3' pre-RNA subunit 2provided by MGI
    Primary source
    MGI:MGI:1343054
    See related
    Ensembl:ENSMUSG00000031256 AllianceGenome:MGI:1343054
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cstf64; mir-3112; C630034J23Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA 3'-end processing. Predicted to be located in cleavage body. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex ventricular layer; and cortical plate. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human CSTF2 (cleavage stimulation factor subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cortex adult (RPKM 16.0), CNS E18 (RPKM 16.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cstf2 in Genome Data Viewer
    Location:
    X E3; X 55.63 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (132959925..132987571)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (134059176..134086822)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 4 Neighboring gene predicted gene 7841 Neighboring gene microRNA 3112 Neighboring gene predicted gene, 54083 Neighboring gene NADPH oxidase 1 Neighboring gene X-linked Kx blood group related, X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dynamic nature of cleavage bodies and their spatial relationship to DDX1 bodies, Cajal bodies, and gems. Li L, et al. Mol Biol Cell, 2006 Mar. PMID 16371507, Free PMC Article
    2. CstF-64 is necessary for endoderm differentiation resulting in cardiomyocyte defects. Youngblood BA, et al. Stem Cell Res, 2014 Nov. PMID 25460602, Free PMC Article
    3. CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing. Youngblood BA, et al. Nucleic Acids Res, 2014 Jul. PMID 24957598, Free PMC Article
    4. Developmental distribution of the polyadenylation protein CstF-64 and the variant tauCstF-64 in mouse and rat testis. Wallace AM, et al. Biol Reprod, 2004 Apr. PMID 14681198
    5. Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers. Monarez RR, et al. Biochem J, 2007 Feb 1. PMID 17029590, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that CstF-64 plays a key role in modulating the cell cycle in embryonic stem cells while simultaneously controlling histone mRNA 3' end processing.
      Title: CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing.
    2. ELL2 and CstF-64 tracked together with RNA polymerase II across the Igh mu- and gamma-gene segments
      Title: Transcription elongation factor ELL2 directs immunoglobulin secretion in plasma cells by stimulating altered RNA processing.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to nerve growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA 3'-end processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cleavage body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cleavage body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cleavage stimulation factor subunit 2
    Names
    CF-1 64 kDa subunit
    CSTF 64 kDa subunit
    cleavage stimulation factor, 3' pre-RNA subunit 2, 64 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290398.1 → NP_001277327.1  cleavage stimulation factor subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_001277327.1

      Status: VALIDATED

      Source sequence(s)
      AI850965, AK049971, AK147438, CJ183629
      Consensus CDS
      CCDS72430.1
      UniProtKB/TrEMBL
      A2AEK1, B3V099
      Related
      ENSMUSP00000108912.2, ENSMUST00000113287.8
      Conserved Domains (4) summary
      COG0724
      Location:16 → 104
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12671
      Location:18 → 92
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:510 → 550
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:113 → 191
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

    2. NM_001290399.1 → NP_001277328.1  cleavage stimulation factor subunit 2 isoform 3

      See identical proteins and their annotated locations for NP_001277328.1

      Status: VALIDATED

      Source sequence(s)
      AK032817, AL671915, BE953679, CJ183629
      Consensus CDS
      CCDS81170.1
      UniProtKB/TrEMBL
      B3V097
      Related
      ENSMUSP00000108911.2, ENSMUST00000113286.8
      Conserved Domains (4) summary
      PRK14718
      Location:395 → 452
      PRK14718; ribonuclease III; Provisional
      pfam09606
      Location:183 → 401
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam14327
      Location:112 → 191
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
      cd12671
      Location:10 → 94
      RRM_CSTF2_CSTF2T; RNA recognition motif (RRM) found in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins

    3. NM_001359053.1 → NP_001345982.1  cleavage stimulation factor subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AI850965, AL671915
      UniProtKB/TrEMBL
      B3V099
      Conserved Domains (5) summary
      cd12671
      Location:18 → 92
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:559 → 599
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:113 → 191
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
      cl25887
      Location:7 → 332
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl25983
      Location:418 → 475
      Rnc; dsRNA-specific ribonuclease [Transcription]

    4. NM_001359054.1 → NP_001345983.1  cleavage stimulation factor subunit 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AI850965, AL671915
      UniProtKB/TrEMBL
      B3V099
      Conserved Domains (4) summary
      cd12671
      Location:18 → 92
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:530 → 570
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:113 → 191
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2
      cl25887
      Location:18 → 447
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    5. NM_133196.6 → NP_573459.1  cleavage stimulation factor subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_573459.1

      Status: VALIDATED

      Source sequence(s)
      AI850965, AK032817, AK147438, AL671915, CJ183629
      Consensus CDS
      CCDS30389.1
      UniProtKB/Swiss-Prot
      A2AEJ9, A2AEK0, Q8BIQ5, Q8K1Y6, Q9ERC2
      UniProtKB/TrEMBL
      B3V099
      Related
      ENSMUSP00000033609.3, ENSMUST00000033609.9
      Conserved Domains (4) summary
      COG0724
      Location:16 → 104
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12671
      Location:18 → 92
      RRM_CSTF2_CSTF2T; RNA recognition motif in cleavage stimulation factor subunit 2 (CSTF2), cleavage stimulation factor subunit 2 tau variant (CSTF2T) and similar proteins
      pfam14304
      Location:536 → 576
      CSTF_C; Transcription termination and cleavage factor C-terminal
      pfam14327
      Location:113 → 191
      CSTF2_hinge; Hinge domain of cleavage stimulation factor subunit 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      132959925..132987571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIQ5.2 GenPept UniProtKB/Swiss-Prot:Q8BIQ5

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