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    orion orion [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31712, updated on 2-Nov-2024

    Summary

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    Official Symbol
    orionprovided by FlyBase
    Official Full Name
    orionprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027280
    Locus tag
    Dmel_CG2206
    See related
    AllianceGenome:FB:FBgn0027280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG2206; Dmel\CG2206; l(1)G0193; l(1)G0327; Orion
    Summary
    Enables chemokine activity. Involved in astrocyte chemotaxis; mushroom body development; and positive regulation of neuron remodeling. Is active in extracellular region. Is expressed in several structures, including adult head; anterior endoderm anlage; larval muscle cell; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See orion in Genome Data Viewer
    Location:
    7C9-7C9; 1-21 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7941478..7946908, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7835511..7840941, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ribosomal protein S14a Neighboring gene Ribosomal protein S14b Neighboring gene Ubr3 ubiquitin ligase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms. Perron C, et al. Development, 2023 Oct 1. PMID 37767633, Free PMC Article
    2. Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling. Boulanger A, et al. Nat Commun, 2021 Mar 23. PMID 33758182, Free PMC Article
    3. The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons. Ji H, et al. Proc Natl Acad Sci U S A, 2023 Jun 13. PMID 37276397, Free PMC Article
    4. Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. Pillmann H, et al. BMC Bioinformatics, 2011 Jun 30. PMID 21718515, Free PMC Article
    5. Neuron-glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila. Boulanger A, et al. Bioessays, 2022 May. PMID 35315125

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.
      Title: The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chemokine activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in astrocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in extracellular region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    orion
    Names
    CG2206-PA
    CG2206-PB
    lethal (1) G0193
    orion-PA
    orion-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7941478..7946908 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132199.4 → NP_572427.1  orion, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3M4
      Related
      FBpp0071081
      Conserved Domains (2) summary
      COG0840
      Location:10 → 136
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      pfam16061
      Location:202 → 456
      DUF4803; Domain of unknown function (DUF4803)

    2. NM_206643.2 → NP_996366.1  orion, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVT8
      Conserved Domains (1) summary
      pfam16061
      Location:184 → 438
      DUF4803; Domain of unknown function (DUF4803)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KVT8 Q7KVT8
    Q9W3M4 Q9W3M4

    Gene LinkOut

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