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    Pik3r2 phosphoinositide-3-kinase regulatory subunit 2 [ Cricetulus griseus (Chinese hamster) ]

    Gene ID: 100771181, updated on 8-Mar-2024

    Summary

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    Gene symbol
    Pik3r2
    Gene description
    phosphoinositide-3-kinase regulatory subunit 2
    Locus tag
    I79_005111
    See related
    Ensembl:ENSCGRG00015001303
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cricetulus griseus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Cricetinae; Cricetulus
    Annotation information
    Annotation category: partial on reference assembly
    Orthologs
    human mouse all
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    Genomic context

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    See Pik3r2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    104 current CriGri_1.0 (GCF_000223135.1) Unplaced Scaffold NW_003613716.1 (1051223..1058545, complement)
    104 current CriGri-PICRH-1.0 (GCF_003668045.3) 1 Unlocalized Scaffold NW_023276806.1 (248233211..248241725)

    NW_003613716.1Genomic Context describing neighboring genes Neighboring gene MPV17 mitochondrial inner membrane protein like 2 Neighboring gene IFI30 lysosomal thiol reductase Neighboring gene microtubule associated serine/threonine kinase 3 Neighboring gene interleukin 12 receptor subunit beta 1 Neighboring gene arrestin domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing. Becker J, et al. J Biotechnol, 2011 Dec 10. PMID 21945585
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase regulatory subunit beta
    Names
    Phosphatidylinositol 3-kinase regulatory subunit beta
    phosphoinositide-3-kinase, regulatory subunit 2 (beta)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cricetulus griseus Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference CriGri_1.0 Primary Assembly

    Genomic

    1. NW_003613716.1 Reference CriGri_1.0 Primary Assembly

      Range
      1051223..1058545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_035451251.1 → XP_035307142.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1

      UniProtKB/TrEMBL
      A0A061IJT4, A0A9J7F6F3
      Conserved Domains (5) summary
      cd09930
      Location:609 → 712
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:316 → 426
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:7 → 80
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:431 → 591
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      cl02570
      Location:110 → 289
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    Alternate CriGri-PICRH-1.0

    Genomic

    1. NW_023276806.1 Alternate CriGri-PICRH-1.0

      Range
      248233211..248241725
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_027394738.2 → XP_027250539.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X2

      UniProtKB/TrEMBL
      A0A061IJT4, A0A9J7F6F3
      Related
      ENSCGRP00015001613.2, ENSCGRT00015002025.2
      Conserved Domains (5) summary
      cd09930
      Location:609 → 712
      SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
      cd09942
      Location:316 → 426
      SH2_nSH2_p85_like; N-terminal Src homology 2 (nSH2) domain found in p85
      cd11909
      Location:7 → 80
      SH3_PI3K_p85beta; Src Homology 3 domain of the p85beta regulatory subunit of Class IA Phosphatidylinositol 3-kinases
      cd12926
      Location:431 → 591
      iSH2_PIK3R2; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunit 2, PIK3R2, also called p85beta
      cl02570
      Location:110 → 289
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

    2. XM_027394739.2 → XP_027250540.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X3

      UniProtKB/TrEMBL
      A0A061IJT4, A0A9J7F9A5
      Related
      ENSCGRP00015001560.2, ENSCGRT00015001962.2

    3. XM_027394741.2 → XP_027250542.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X5

      UniProtKB/TrEMBL
      A0A9J7J8V0

    4. XM_027394743.2 → XP_027250544.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X5

      UniProtKB/TrEMBL
      A0A9J7J8V0

    5. XM_027394740.2 → XP_027250541.1  phosphatidylinositol 3-kinase regulatory subunit beta isoform X4

      UniProtKB/TrEMBL
      A0A061IJT4, A0A9J7F425
    Nucleotide Protein Strain
    Heading Accession and Version

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