AFB3 auxin signaling F-box 3 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AFB3
Official Full Name: auxin signaling F-box 3
Primary source: TAIR:AT1G12820
Locus tag: AT1G12820
See related: Araport:AT1G12820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: auxin signaling F-box 3; F13K23.7; F13K23_7
Summary: Auxin receptor involved in primary and lateral root growth inhibition in response to nitrate. Target of miR393. Induced by nitrate in primary roots.
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Genomic context

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See AFB3 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (4368760..4371298, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of the Auxin Receptor AFB3 in Arabidopsis Results in Salt Stress Resistance and the Modulation of NAC4 and SZF1.
Title: Overexpression of the Auxin Receptor AFB3 in Arabidopsis Results in Salt Stress Resistance and the Modulation of NAC4 and SZF1.
Auxin signaling through TIR1/AFB2/AFB3 mediates feedback regulation of indole-3-acetic acid biosynthesis.
Title: Auxin signaling through SCF(TIR1/AFBs) mediates feedback regulation of IAA biosynthesis.
gene expression in response to nitrate treatment of the AFB3 auxin receptor and its target, the NAC4 transcription factor, depends on the nitrate transport function of NRT1.1
Title: Nitrate regulation of AFB3 and NAC4 gene expression in Arabidopsis roots depends on NRT1.1 nitrate transport function.
AFB3 is able to activate two independent pathways to control root system architecture.
Title: Systems approaches map regulatory networks downstream of the auxin receptor AFB3 in the nitrate response of Arabidopsis thaliana roots.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101152.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables auxin binding	IGI Inferred from Genetic Interaction more info	PubMed
enables auxin binding	ISS Inferred from Sequence or Structural Similarity more info
enables inositol hexakisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in auxin-activated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to nitrate	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lateral root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen maturation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within primary root development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stamen development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: auxin signaling F-box 3

NP_563915.1

auxin signaling F-box 3 (AFB3); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810); BEST Arabidopsis thaliana protein match is: auxin signaling F-box 2 (TAIR:AT3G26810.1); Has 2450 Blast hits to 1661 proteins in 170 species: Archae - 0; Bacteria - 4; Metazoa - 823; Fungi - 153; Plants - 1347; Viruses - 0; Other Eukaryotes - 123 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

4368760..4371298 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101152.5 → NP_563915.1 auxin signaling F-box 3 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_563915.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LPW7

UniProtKB/TrEMBL

A0A178WFK2, A0A5S9U4U7

Conserved Domains (4) summary

cd09293
Location:262 → 393

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:286 → 311

LRR_AMN1; leucine-rich repeat [structural motif]

pfam18511
Location:1 → 42

F-box_5

pfam18791
Location:61 → 107

Transp_inhibit; Transport inhibitor response 1 protein domain