Tcf3 transcription factor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf3provided by MGI
Official Full Name: transcription factor 3provided by MGI
Primary source: MGI:MGI:98510
See related: Ensembl:ENSMUSG00000020167 AllianceGenome:MGI:98510
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A1; E12; E2A; E47; KA1; ME2; ALF2; Pan1; Pan2; VDIR; TCF-3; Tcfe2a; E12/E47; bHLHb21
Summary: Enables several functions, including DNA-binding transcription factor binding activity; E-box binding activity; and protein heterodimerization activity. Contributes to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gastrulation; positive regulation of neuron differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of with a positive effect on transcription by RNA polymerase II. Acts upstream of or within several processes, including immune system development; lymphocyte differentiation; and regulation of gene expression. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex and nucleosome. Is expressed in several structures, including brain; branchial arch; genitourinary system; integument; and retina. Used to study acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in agammaglobulinemia 8A; agammaglobulinemia 8B; and colorectal cancer. Orthologous to human TCF3 (transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 71.9), spleen adult (RPKM 58.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80245375..80269814, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80409541..80433976, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
Title: Mapping putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators.
TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
Title: TCF3 haploinsufficiency defined by immune, clinical, gene-dosage, and murine studies.
Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.
Title: Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.
Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
Title: Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3.
Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.
Title: Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis.
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Title: TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.
Title: The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells.
MiR-506-3p Promotes the Proliferation and Migration of Vascular Smooth Muscle Cells via Targeting KLF4.
Title: MiR-506-3p Promotes the Proliferation and Migration of Vascular Smooth Muscle Cells via Targeting KLF4.
Tcf3-activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy.
Title: Tcf3-activated lncRNA Gas5 regulates newborn mouse cardiomyocyte apoptosis in diabetic cardiomyopathy.
The transcription factor E2A drives neural differentiation in pluripotent cells.
Title: The transcription factor E2A drives neural differentiation in pluripotent cells.

Submit: New GeneRIF Correction See all GeneRIFs (129)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (22) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW209082 (e-PCR)
- UniSTS:180078

Tcfe2a (e-PCR), detects polymorphism
- UniSTS:265586

D10Mit23 (e-PCR), detects polymorphism
- UniSTS:126133

Tcfe2a (e-PCR), detects polymorphism
- UniSTS:144566

Tcfe2a (e-PCR), detects polymorphism
- UniSTS:144567

Tcfe2a (e-PCR), detects polymorphism
- UniSTS:256454

Tcf3 (e-PCR), detects polymorphism
- UniSTS:527575

RH124709 (e-PCR)
- UniSTS:161531

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
contributes_to DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
contributes_to E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to E-box binding	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables bHLH transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
contributes_to transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables vitamin D response element binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in B cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within Peyer's patch development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within T cell differentiation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect erythrocyte differentiation	TAS Traceable Author Statement more info	PubMed
involved_in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immunoglobulin V(D)J recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immunoglobulin V(D)J recombination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immunoglobulin V(D)J recombination	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within lymphocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of B cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein stabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of G1/S transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II transcription regulator complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in euchromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor E2-alpha

Names: immunoglobulin enhancer-binding factor E12/E47; transcription factor A1; transcription factor E2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164147.2 → NP_001157619.1 transcription factor E2-alpha isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC152062

Consensus CDS

CCDS48636.1

UniProtKB/TrEMBL

E9PWE2, E9PWE5

Related

ENSMUSP00000100979.2, ENSMUST00000105342.8

Conserved Domains (2) summary

smart00353
Location:554 → 607

HLH; helix loop helix domain

cl23750
Location:487 → 562

vATP-synt_E; ATP synthase (E/31 kDa) subunit
NM_001164148.2 → NP_001157620.1 transcription factor E2-alpha isoform 2

See identical proteins and their annotated locations for NP_001157620.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS48634.1

UniProtKB/TrEMBL

A0A0R4J014, E9PWE5

Related

ENSMUSP00000020377.7, ENSMUST00000020377.13

Conserved Domains (2) summary

smart00353
Location:553 → 606

HLH; helix loop helix domain

cl23750
Location:486 → 561

vATP-synt_E; ATP synthase (E/31 kDa) subunit
NM_001164149.2 → NP_001157621.1 transcription factor E2-alpha isoform 3

See identical proteins and their annotated locations for NP_001157621.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) has two alternate splice sites in the coding region, compared to variant 1. The resulting isoform (3) lacks two internal aa, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS48630.1

UniProtKB/Swiss-Prot

P15806, Q3U153, Q8CAH9, Q8VCY4, Q922S2, Q99MB8, Q9CYJ4

UniProtKB/TrEMBL

E9PWE5

Related

ENSMUSP00000100983.4, ENSMUST00000105346.10

Conserved Domains (2) summary

smart00353
Location:552 → 605

HLH; helix loop helix domain

cl23750
Location:485 → 560

vATP-synt_E; ATP synthase (E/31 kDa) subunit
NM_001164150.2 → NP_001157622.1 transcription factor E2-alpha isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) has an alternate penultimate coding exon, compared to variant 1. The resulting isoform (4) has a distinct segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS48635.1

UniProtKB/TrEMBL

E9PVV1, E9PWE3

Related

ENSMUSP00000100981.2, ENSMUST00000105344.8

Conserved Domains (2) summary

smart00353
Location:551 → 604

HLH; helix loop helix domain

pfam08614
Location:455 → 573

ATG16; Autophagy protein 16 (ATG16)
NM_001164151.2 → NP_001157623.1 transcription factor E2-alpha isoform 5

See identical proteins and their annotated locations for NP_001157623.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) has an alternate splice site and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (5) lacks an internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS48632.1

UniProtKB/TrEMBL

A0A0R4J011, E9PWE3

Related

ENSMUSP00000020379.7, ENSMUST00000020379.13

Conserved Domains (2) summary

smart00353
Location:550 → 603

HLH; helix loop helix domain

pfam08614
Location:454 → 572

ATG16; Autophagy protein 16 (ATG16)
NM_001164152.2 → NP_001157624.1 transcription factor E2-alpha isoform 6

Status: VALIDATED

Description

Transcript Variant: This variant (6) has an alternate splice site and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (6) lacks an internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS48633.1

UniProtKB/TrEMBL

E9PVV2, E9PWE3

Related

ENSMUSP00000100980.2, ENSMUST00000105343.8

Conserved Domains (2) summary

smart00353
Location:550 → 603

HLH; helix loop helix domain

pfam08614
Location:454 → 572

ATG16; Autophagy protein 16 (ATG16)
NM_001164153.2 → NP_001157625.1 transcription factor E2-alpha isoform 7

Status: VALIDATED

Description

Transcript Variant: This variant (7) has an alternate splice site and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (7) lacks an internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS48631.1

UniProtKB/TrEMBL

E9PWE3, E9PWE4

Related

ENSMUSP00000100977.2, ENSMUST00000105340.8

Conserved Domains (1) summary

smart00353
Location:549 → 602

HLH; helix loop helix domain
NM_001378903.1 → NP_001365832.1 transcription factor E2-alpha isoform 9

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE5

Conserved Domains (2) summary

PHA03247
Location:128 → 380

PHA03247; large tegument protein UL36; Provisional

cd18945
Location:541 → 625

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
NM_001378904.1 → NP_001365833.1 transcription factor E2-alpha isoform 10

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE5

Conserved Domains (2) summary

PHA03247
Location:128 → 381

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:548 → 604

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_001378905.1 → NP_001365834.1 transcription factor E2-alpha isoform 11

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE5

Conserved Domains (2) summary

PHA03247
Location:128 → 380

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:547 → 603

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_001378908.1 → NP_001365837.1 transcription factor E2-alpha isoform 12

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE5

Conserved Domains (2) summary

PHA03247
Location:128 → 381

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:547 → 603

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_001378910.1 → NP_001365839.1 transcription factor E2-alpha isoform 13

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE5

Conserved Domains (2) summary

PHA03247
Location:128 → 380

PHA03247; large tegument protein UL36; Provisional

cl00081
Location:546 → 602

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
NM_001378912.1 → NP_001365841.1 transcription factor E2-alpha isoform 14

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE3

Conserved Domains (1) summary

PHA03247
Location:128 → 379

PHA03247; large tegument protein UL36; Provisional
NM_001378913.1 → NP_001365842.1 transcription factor E2-alpha isoform 15

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE3
NM_001378914.1 → NP_001365843.1 transcription factor E2-alpha isoform 16

Status: VALIDATED

Source sequence(s)

AC152062

UniProtKB/TrEMBL

E9PWE3
NM_011548.5 → NP_035678.3 transcription factor E2-alpha isoform 8

Status: VALIDATED

Description

Transcript Variant: This variant (8) has two alternate splice sites and an alternate penultimate coding exon, compared to variant 1. The resulting isoform (8) lacks two internal aa and has a distinct segment in the C-terminal region, compared to isoform 1.

Source sequence(s)

AC152062

Consensus CDS

CCDS24022.1

UniProtKB/TrEMBL

E9PWE3

Related

ENSMUSP00000100982.4, ENSMUST00000105345.10

Conserved Domains (2) summary

smart00353
Location:549 → 602

HLH; helix loop helix domain

pfam08614
Location:453 → 571

ATG16; Autophagy protein 16 (ATG16)

RNA

NR_166173.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC152062

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

80245375..80269814 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244995.2 → XP_030100855.1 transcription factor E2-alpha isoform X2

UniProtKB/TrEMBL

E9PWE3

Conserved Domains (1) summary

PHA03247
Location:128 → 379

PHA03247; large tegument protein UL36; Provisional
XM_017313872.3 → XP_017169361.1 transcription factor E2-alpha isoform X1

UniProtKB/TrEMBL

E9PWE5

Conserved Domains (2) summary

PHA03247
Location:92 → 345

PHA03247; large tegument protein UL36; Provisional

cd18945
Location:506 → 590

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins