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    PLEC plectin [ Hylobates moloch (silvery gibbon) ]

    Gene ID: 116813679, updated on 18-Mar-2024

    Summary

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    Gene symbol
    PLEC
    Gene description
    plectin
    See related
    EnsemblRapid:ENSHMOG00010016416
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Hylobates moloch
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Hylobates
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See PLEC in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2023_07 current HMol_V3 (GCF_009828535.3) Unplaced Scaffold NW_026652284.1 (124134242..124194870, complement)

    NW_026652284.1Genomic Context describing neighboring genes Neighboring gene epiplakin 1 Neighboring gene large ribosomal subunit protein eL42-like Neighboring gene poly(ADP-ribose) polymerase family member 10 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1 Neighboring gene uncharacterized LOC116813685 Neighboring gene spermatogenesis and centriole associated 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_026652284 Unplaced Scaffold Reference HMol_V3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ankyrin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cadherin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables keratin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables structural constituent of muscle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hemidesmosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in intermediate filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in wound healing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in hemidesmosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plectin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: GCF_009828535.3-RS_2023_07

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HMol_V3

    Genomic

    1. NW_026652284.1 Reference HMol_V3

      Range
      124134242..124194870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_058443657.1 → XP_058299640.1  plectin isoform X5

    2. XM_058443655.1 → XP_058299638.1  plectin isoform X3

    3. XM_058443656.1 → XP_058299639.1  plectin isoform X4

    4. XM_058443654.1 → XP_058299637.1  plectin isoform X2

    5. XM_032760707.2 → XP_032616598.1  plectin isoform X1

      Conserved Domains (10) summary
      TIGR00618
      Location:2294 → 2737
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1389 → 2095
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2810 → 2846
      PLEC; Plectin repeat
      COG1196
      Location:998 → 1625
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:662 → 842
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4085 → 4124
      Plectin; Plectin repeat
      pfam17902
      Location:837 → 903
      SH3_10; SH3 domain
      pfam18373
      Location:938 → 1015
      Spectrin_like; Spectrin like domain
      cd21188
      Location:68 → 189
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:202 → 307
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    6. XM_058443658.1 → XP_058299641.1  plectin isoform X18

    7. XM_032760721.2 → XP_032616612.1  plectin isoform X16

      Conserved Domains (10) summary
      TIGR00618
      Location:2241 → 2684
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1336 → 2042
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2757 → 2793
      PLEC; Plectin repeat
      COG1196
      Location:945 → 1572
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:609 → 789
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4032 → 4071
      Plectin; Plectin repeat
      pfam17902
      Location:784 → 850
      SH3_10; SH3 domain
      pfam18373
      Location:885 → 962
      Spectrin_like; Spectrin like domain
      cd21238
      Location:149 → 254
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
      cl00030
      Location:18 → 145
      CH_SF; calponin homology (CH) domain superfamily

    8. XM_032760717.2 → XP_032616608.1  plectin isoform X12

      Conserved Domains (10) summary
      TIGR00618
      Location:2253 → 2696
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1348 → 2054
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2769 → 2805
      PLEC; Plectin repeat
      COG1196
      Location:957 → 1584
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:621 → 801
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4044 → 4083
      Plectin; Plectin repeat
      pfam17902
      Location:796 → 862
      SH3_10; SH3 domain
      pfam18373
      Location:897 → 974
      Spectrin_like; Spectrin like domain
      cd21188
      Location:32 → 148
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:161 → 266
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    9. XM_032760715.2 → XP_032616606.1  plectin isoform X10

      Conserved Domains (10) summary
      TIGR00618
      Location:2258 → 2701
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1353 → 2059
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2774 → 2810
      PLEC; Plectin repeat
      COG1196
      Location:962 → 1589
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:626 → 806
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4049 → 4088
      Plectin; Plectin repeat
      pfam17902
      Location:801 → 867
      SH3_10; SH3 domain
      pfam18373
      Location:902 → 979
      Spectrin_like; Spectrin like domain
      cd21188
      Location:32 → 153
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:166 → 271
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    10. XM_032760722.2 → XP_032616613.1  plectin isoform X17

      Conserved Domains (10) summary
      TIGR00618
      Location:2240 → 2683
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1335 → 2041
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2756 → 2792
      PLEC; Plectin repeat
      COG1196
      Location:944 → 1571
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:608 → 788
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4031 → 4070
      Plectin; Plectin repeat
      pfam17902
      Location:783 → 849
      SH3_10; SH3 domain
      pfam18373
      Location:884 → 961
      Spectrin_like; Spectrin like domain
      cd21188
      Location:19 → 135
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:148 → 253
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    11. XM_032760720.2 → XP_032616611.1  plectin isoform X15

      Conserved Domains (10) summary
      TIGR00618
      Location:2245 → 2688
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1340 → 2046
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2761 → 2797
      PLEC; Plectin repeat
      COG1196
      Location:949 → 1576
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:613 → 793
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4036 → 4075
      Plectin; Plectin repeat
      pfam17902
      Location:788 → 854
      SH3_10; SH3 domain
      pfam18373
      Location:889 → 966
      Spectrin_like; Spectrin like domain
      cd21188
      Location:19 → 140
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:153 → 258
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    12. XM_032760705.2 → XP_032616596.1  plectin isoform X19

      Related
      ENSHMOT00010024924.1
      Conserved Domains (12) summary
      TIGR00618
      Location:2387 → 2830
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1482 → 2188
      PTZ00121; MAEBL; Provisional
      smart00150
      Location:659 → 753
      SPEC; Spectrin repeats
      smart00250
      Location:4063 → 4100
      PLEC; Plectin repeat
      COG1196
      Location:1091 → 1718
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:755 → 935
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4178 → 4217
      Plectin; Plectin repeat
      pfam03501
      Location:7 → 99
      S10_plectin; Plectin/S10 domain
      pfam17902
      Location:930 → 996
      SH3_10; SH3 domain
      pfam18373
      Location:1031 → 1108
      Spectrin_like; Spectrin like domain
      cd21188
      Location:178 → 282
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:295 → 400
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    13. XM_032760719.2 → XP_032616610.1  plectin isoform X14

      Conserved Domains (10) summary
      TIGR00618
      Location:2250 → 2693
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1345 → 2051
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2766 → 2802
      PLEC; Plectin repeat
      COG1196
      Location:954 → 1581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:618 → 798
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4041 → 4080
      Plectin; Plectin repeat
      pfam17902
      Location:793 → 859
      SH3_10; SH3 domain
      pfam18373
      Location:894 → 971
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 145
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:158 → 263
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    14. XM_032760714.2 → XP_032616605.1  plectin isoform X9

      Conserved Domains (10) summary
      TIGR00618
      Location:2262 → 2705
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1357 → 2063
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2778 → 2814
      PLEC; Plectin repeat
      COG1196
      Location:966 → 1593
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:630 → 810
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4053 → 4092
      Plectin; Plectin repeat
      pfam17902
      Location:805 → 871
      SH3_10; SH3 domain
      pfam18373
      Location:906 → 983
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 157
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:170 → 275
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    15. XM_032760716.2 → XP_032616607.1  plectin isoform X11

      Conserved Domains (10) summary
      TIGR00618
      Location:2255 → 2698
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1350 → 2056
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2771 → 2807
      PLEC; Plectin repeat
      COG1196
      Location:959 → 1586
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:623 → 803
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4046 → 4085
      Plectin; Plectin repeat
      pfam17902
      Location:798 → 864
      SH3_10; SH3 domain
      pfam18373
      Location:899 → 976
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 150
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:163 → 268
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    16. XM_032760712.2 → XP_032616603.1  plectin isoform X7

      Conserved Domains (10) summary
      TIGR00618
      Location:2267 → 2710
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1362 → 2068
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2783 → 2819
      PLEC; Plectin repeat
      COG1196
      Location:971 → 1598
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:635 → 815
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4058 → 4097
      Plectin; Plectin repeat
      pfam17902
      Location:810 → 876
      SH3_10; SH3 domain
      pfam18373
      Location:911 → 988
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 162
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:175 → 280
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    17. XM_032760713.2 → XP_032616604.1  plectin isoform X8

      Conserved Domains (10) summary
      TIGR00618
      Location:2262 → 2705
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1357 → 2063
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2778 → 2814
      PLEC; Plectin repeat
      COG1196
      Location:966 → 1593
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:630 → 810
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4053 → 4092
      Plectin; Plectin repeat
      pfam17902
      Location:805 → 871
      SH3_10; SH3 domain
      pfam18373
      Location:906 → 983
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 157
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:170 → 275
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    18. XM_032760711.2 → XP_032616602.1  plectin isoform X6

      Conserved Domains (10) summary
      TIGR00618
      Location:2267 → 2710
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1362 → 2068
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2783 → 2819
      PLEC; Plectin repeat
      COG1196
      Location:971 → 1598
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:635 → 815
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4058 → 4097
      Plectin; Plectin repeat
      pfam17902
      Location:810 → 876
      SH3_10; SH3 domain
      pfam18373
      Location:911 → 988
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 162
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:175 → 280
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins

    19. XM_032760718.2 → XP_032616609.1  plectin isoform X13

      Conserved Domains (10) summary
      TIGR00618
      Location:2250 → 2693
      sbcc; exonuclease SbcC
      PTZ00121
      Location:1345 → 2051
      PTZ00121; MAEBL; Provisional
      smart00250
      Location:2766 → 2802
      PLEC; Plectin repeat
      COG1196
      Location:954 → 1581
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:618 → 798
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam00681
      Location:4041 → 4080
      Plectin; Plectin repeat
      pfam17902
      Location:793 → 859
      SH3_10; SH3 domain
      pfam18373
      Location:894 → 971
      Spectrin_like; Spectrin like domain
      cd21188
      Location:41 → 145
      CH_PLEC-like_rpt1; first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family
      cd21238
      Location:158 → 263
      CH_PLEC_rpt2; second calponin homology (CH) domain found in plectin and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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