HSP90AB1 heat shock protein 90 alpha family class B member 1 [Bos taurus (cattle)] - Gene

Summary

Official Symbol: HSP90AB1provided by VGNC
Official Full Name: heat shock protein 90 alpha family class B member 1provided by VGNC
Primary source: VGNC:VGNC:55918
See related: BGD:BT11507; Ensembl:ENSBTAG00000000778
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: HSPCB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	23	NC_037350.1 (17752495..17758156)

Chromosome 23 - NC_037350.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037350.1 Chromosome 23 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Heat tolerance was assessed in Boran and Nguni cows. Protein levels of HSP90AB1, skin thickness, rectal and skin temperature were higher in the Boran cows than Nguni cows. Breed, age and coat colour did not influence HSP90AB1 concentration.
Title: Thermotolerance, health profile and cellular expression of HSP90AB1 in Nguni and Boran cows raised on natural pastures under tropical conditions.
Studied the nucleotide polymorphism within the HSP90AB1 gene (SNP g.4338T>C) in Indian breeds of dairy cattle.
Title: Identification of SNP in HSP90AB1 and its association with the relative thermotolerance and milk production traits in Indian dairy cattle.
Association analysis revealed that the T allele at SNP g.4338T>C of the HSP90AB1 gene improved heat tolerance in cattle. Allele T was 100% in White Lamphun animals, 84% in Mountain cattle, and 18% in Holstein Friesian heifers.
Title: Polymorphisms in the bovine HSP90AB1 gene are associated with heat tolerance in Thai indigenous cattle.
This study showed that ubiquitinated ALK5 and phosphorylated heat shock protein 27 specifically accumulate in the cytoskeleton fraction, and ALK1 and ALK5 interact with heat shock protein 90(HSP90).
Title: Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90.
the protective effect exerted by HSP90 on eNOS degradation mediated by calpain represents a novel and critical mechanism that assures the reversibility of the intracellular trafficking and activation of the synthase
Title: Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_6805-6806:992007483:1 (e-PCR)
- UniSTS:231275

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info	PubMed
enables disordered domain specific binding	IEA Inferred from Electronic Annotation more info	PubMed
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to heat	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heat shock protein HSP 90-beta

Names: heat shock 90 kDa protein; heat shock 90kDa protein 1, beta; heat shock protein 90kDa alpha (cytosolic), class B member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.